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Biomedical subjects

C Pasquier

Publications and source records attributed to C Pasquier.

At least 109 records · Page 6Linked to original sources
PubMed1982

[A system of automatic analysis for ambulatory recordings].

Magnetic ambulatory recordings were made on cassettes and analysed at 60 times the original recording speed using an analogical system. The amplitude of EEG was directly inscribed, in 6 different frequency bands, on paper. Limits of bands are 1, 2, 4, 8, 12, 24 (spindles) and 48 Hz. Included in the system are: automatic detection of rolandic paroxysms, detection of apneas after continuous recording of the respiratory movement and a cardiac frequency monitor. These additional parameters make the interpretation easier. The results and curves obtained are similar to those found in other methods elsewhere. Sigma rhythm or increase of delta activity during sleep are evident. Over long recording periods, research for respiratory apneas and cardiac rhythm variations is quick and easy to do. It is also possible to compare an entire day's paroxysmal activity on either right or left rolandic derivations. This system thus supplies information on various situations: disturbance of vigilance, study of interictal paroxysmal activity or detection of cardiac or respiratory pathology.

Ambulatory Care↗
PubMed1980

Induction and inhibition of bone matrix resorption.

A method is described by which the action of hormones on cartilage and bone matrix in mice is ascertained by measuring 35S release from bone explants. Parathyroid extract was found to increase the rate of 35S release in vitro as well as in samples from pretreated animals, whereas calcitonin and 25-hydroxycholecalciferol were effective only in vitro.

Animals↗
PubMed1979

Pharmacokinetic parameters of 14C oxithiopurinol in rat.

The study with labelled compound has shown that in rat, as in man, thiopurinol is primarily and rapidly converted into oxithiopurinol. More than 80% of the radioactivity of plasma was identified as oxithiopurinol less than 10 minutes after intravenous or oral administration. The parameters of oxithiopurinol were estimated from the decline of radioactivity in blood from 5 minutes to 8 hours after intravenous administration of 4 microCi/100 g of thiopurinol (8 animals) or oxithiopurinol (5 animals). Half lives of oxithiopurinol t 1/2 (beta) were 2.52 +/- 0.78 hr and 2.90 +/- 1.00 hr and clearance 2.00 +/- 0.36 ml/min. and 3.38 +/- 0.69 respectively. Estimate of renal clearance for oxithiopurinol in rat was 4,17 ml/min. The rapidity of hydroxylation and of elimination of oxithiopurinol might be assumed to be the cause of the apparent ineffectiveness of thiopurinol in vivo on xanthine oxidase activity.

Animals↗
PubMed1978

Variation of hepatic mitochondrial nucleotides in rats contaminated with plutonium-239.

Rats were given 239Pu citrate i.v. and the mitochondria of hepatocytes were studied. A reduction of oxygen consumption per mg protein with time was seen. We have investigated the nucleotides involved in nuclear phosphorylation. After mitochondrial extraction according to Schneider and Hogeboom, [1950], a new method was used for estimating CMP, NAD, 5' AMP, NADP, ADP and GTP. Flavine mononucleotide was not determined. The plutonium content was followed from day 0 to day 65 post injection. Mitochondrial nucleotides were studied on days 5 and 11. On day 5, all nucleotide levels were reduced by 20 to 70% except AMP which increased and GTP which remained constant. On day 11, all nucleotides had decreased by 70 to 100% except NAD which increased by 20 to 30%. The results suggest that plutonium citrate given intravenously has a time dependent effect on the energy metabolism of the liver.

Animals↗
PubMed1978

Study of urinary pyrazinamide metabolites and their action on the renal excretion of xanthine and hypoxanthine in a xanthinuric patient.

A chromatographic technique on anion exchange column was developed. It permets to determine unmetabolized pyrazinamide and three major metabolities: pyrazinoic acid, 5-hydroxypyrazinoic acid and an unidentified compound. In a xanthinuric patient only traces of 5-hydroxypyrazinoic acid were found 12 hours after 3 g pyrazinamide were given. These finding confirms that pyrazinoic acid is oxidised through the the action of xanthine oxidase. Both the clearances of hypoxanthine and of xanthine are as rapid as that of endogenous creatinine in a xanthinuric patient. But the effects of pyrazinamide are different on both purine bases. Urinary excretion of hypoxanthine is slightly but not significantly reduced while excretion of xanthine is decreased by about 75%. Evidence was demonstrated that pyrazinoic acid is likely the agent causing xanthine retention. These results suggest that the mechanisms of renal transport of xanthine and hypoxanthine are different.

Chromatography, Ion Exchange↗
PubMed1977

Xanthinuria : study of a large kindred with familial urolithiasis and gout.

We have carried out biochemical and clinical studies on a large family in which xanthinuria, xanthine lithiasis, uric acid lithiasis and/or gout were discovered. The analysis of its pedigree has shown that : a) the mode of transmission of xanthinuria is autosomal recessive; b) the occurence of xanthine urolithiasis is likely to be due to the association of a second genetic disorder.

Female↗
PubMed1975

[Methods of isolation and determination of urinary 4-thio-6-hydroxypyrazolo(3,4 d)pyrimidine in patients treated with thiopurinol].

Oxithiopurinol, [4-thio-6-hydroxypyrazolo(3,4-d)pyrimidine] has been caracterized in urines of patients treated with Thiopurinol : the principle involved is the precipitation of both oxithiopurinol and uric acid in combination with cupric hydroxide. The urinary oxithopurinol content is determined by means of anion and cation exchange resins. 56 to 70 per cent of the daily dose of Thiopurinol are eliminated in urine as oxithiopurinol.

Allopurinol↗