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Biomedical subjects

C Parsons

Publications and source records attributed to C Parsons.

At least 55 records · Page 3Linked to original sources
PubMed1991

Focal myositis, a benign inflammatory pseudotumour: CT appearances.

Focal myositis is a rare benign pseudotumour of skeletal muscle, of unknown cause. Clinically it presents as an enlarging mass within muscle, usually of an extremity, and is often mistaken for a soft tissue neoplasm. The diagnosis is made by biopsy which reveals characteristic histological changes of inflammation, focal degeneration and regeneration, and some evidence of denervation. The CT findings include irregularity and enlargement of the muscles involved, with diffuse, poorly defined fatty infiltration of the muscle planes, but no evidence of an associated mass. We present two cases of focal myositis of the calf, both of which mimicked a soft tissue neoplasm, and in which CT was helpful in determining the nature and extent of the abnormality, for needle biopsy, and follow-up.

Adult↗
PubMed1990

Radiation-induced brachial plexus injury: follow-up of two different fractionation schedules.

All 449 breast cancer patients treated with post-operative radiotherapy to the breast and lymph nodes between 1982 and 1984 have been followed for 3-5.5 years. In this group two different fractionation schedules were used, one five times a fortnight and one daily, both over 6 weeks. The calculated dose to the brachial plexus was 45 Gy in 15 fractions or 54 Gy in 30 fractions. These schedules are equivalent doses using the standard NSD formula. The diagnosis of a brachial plexus injury was made clinically and computed tomography was used to distinguish radiation injury from recurrent disease. The actuarial incidence of a radiation-induced brachial plexus injury for the whole group was 4.9% at 5.5 years. No cases were seen in the first 10 months following radiotherapy. The incidence rises between 1 and 4 years and then starts to plateau. When the large fraction size group is compared with the small fraction size group the incidence at 5.5 years is 5.9% and 1.0%, respectively (p = 0.09). Two different treatment techniques were used in this group but were not found to contribute to the probability of developing a brachial plexus injury. It is suggested that radiation using large doses per fraction are less well tolerated by the brachial plexus than small doses per fraction; a commonly used fractionation schedule such as 45 Gy in 15 fractions may give unacceptably high brachial plexus morbidity; and the use of small doses per fraction or avoiding lymphatic irradiation is advocated.

Brachial Plexus↗
PubMed1990

CT scanning in patients following surgery on the tongue and floor of mouth.

Computed tomographic (CT) scanning was performed on 15 patients who had undergone carefully documented major surgery for malignancy to the tongue and floor of mouth in order to assess appearances of the face and neck following extensive resection. The appearances following a variety of operations, often with reconstruction, were identified. Familiarity with the normal post-operative anatomy allows the recognition of small volume recurrent tumour and the implementation of appropriate treatment.

Humans↗
PubMed1990

Assessment of intestinal amino acid availability in cattle by use of the precision-fed cecectomized rooster assay.

The digestibilities of amino acids in duodenal digesta of steers were measured using a precision-fed cecectomized rooster assay. Freeze-dried duodenal digesta from steers fed five different diets were utilized. Amino acids present in digesta of steers fed diets supplemented with corn gluten meal were more digestible than those from digesta of steers fed diets supplemented with soybean meal, blood meal, fish meal, or no true protein source. Measurements of amino acid digestibility in the cecectomized rooster were similar to those obtained previously when measured with reference to chromic oxide in steers fitted with duodenal and ileal cannulae, suggesting that the precision-fed cecectomized rooster assay is an appropriate technique for estimating small intestinal digestibility of amino acids in cattle.

Amino Acids↗
PubMed1989

Normal CT anatomy of the tongue, floor of mouth and oropharynx.

A computed tomography (CT) technique is described which demonstrates the structures and tissue planes in the floor of mouth, tongue and oropharynx. The anatomy, which forms the basis for understanding pathological change, is given in detail and illustrated by axial and coronal images and line drawings.

Humans↗
PubMed1989

Computed tomographic scanning in patients with carcinoma of the tongue.

Computed tomographic (CT) scanning is useful for staging patients with carcinoma of the tongue. In a study of 13 patients scanned prior to treatment, CT gave additional valuable information about the primary tumour in four patients. Computed tomography detetected non-palpable, abnormal cervical lymph nodes in three patients which directly affected the nature of the subsequent operation.

Adult↗
PubMed1989

The role of lymphography in the management of carcinoma of the endometrium.

In order to assess the role of lymphography in the postoperative management of carcinoma of the endometrium, 57 consecutive cases were analysed retrospectively. Forty-eight patients had undergone definitive surgery and bipedal lymphography was performed in 41 cases (85%). Unilateral pelvic lymphadenopathy was detected in three cases (7%); two stage I, one stage II. In no case did the result of lymphography alter management, based on histological criteria, with either intracavitary radiotherapy alone or in combination with external beam therapy to the pelvis. In a short median follow-up of 11 months (range 2-19 months), four cases have relapsed but all had normal lymphography at initial postoperative staging. Bipedal lymphography has no role in the routine management of carcinoma of the endometrium.

Adult↗
PubMed1988

The anatomy and pathology of the brachial plexus as demonstrated by computed tomography.

Computed tomography (CT) scanning can demonstrate a wide range of abnormalities affecting both the brachial plexus and the surrounding structures. Narrow section (4 mm) CT was used with bolus intravenous enhancement to examine the root of the neck and axilla in 62 patients with cancer, many of whom had symptoms of brachial plexus neuropathy. The normal anatomy of the plexus and its relations are described and illustrated. Examples of pathological changes caused by tumour and irradiation are also presented. The narrow scanning width (4 mm) is needed as the details sought are small and will be missed on thicker slice widths, particularly the changes of fibrosis in the upper axilla. Injection of intravenous contrast medium is essential for identifying the vascular structures which are used to locate the brachial plexus, especially when disease processes and post-irradiation fibrosis have destroyed the tissue planes.

Axilla↗
PubMed1988

The diagnosis by computed tomography of brachial plexus lesions following radiotherapy for carcinoma of the breast.

The region of the brachial plexus in the root of neck and axilla was examined by computed tomography (CT) in 62 patients attending the Royal Marsden Hospital. Forty-two of these patients had been treated by surgery and subsequent radiotherapy for carcinoma of the breast. Computed tomography was able to identify varying grades of abnormality that were ascribed to radiation fibrosis. Twenty-eight patients had neurological symptoms affecting the arm or hand on the treated side and CT changes were seen in 96%. The grading and significance of these CT abnormalities is discussed. The patients had been treated by two different radiotherapy techniques (three-field and four-field) which utilised either a large or small treatment fraction. The higher grades of abnormality on CT were seen in 57% of those treated with the large fraction size and 27% of those treated with the small fraction size. However, the changes on CT did not relate to the different radiotherapy techniques.

Brachial Plexus↗
PubMed1988

The role of abdominal computed tomography in the assessment of patients with malignant tumours of the cervix and body of the uterus.

The value of abdominal computed tomography (CT) in patients with malignant tumours of the body of the uterus and of the cervix is discussed and its efficacy compared with lymphography combined with intravenous urography. There was good correlation between CT and lymphography in the diagnosis of the para-aortic lymphadenopathy and hydronephrosis. Hydronephrosis was the commonest abnormality and tended to be over-diagnosed on CT. Computed tomography conferred no advantage over lymphography in the diagnosis of paraaortic lymphadenopathy or hydronephrosis. Since there were more positive findings in patients undergoing CT at the time of relapse than at the time of initial diagnosis, if indicated at all, abdominal CT should be restricted to patients who have relapsed.

Carcinoma↗
PubMed1987

Pre-operative assessment of soft tissue sarcomas by computed tomography.

The current trend towards limb-sparing surgery in patients with soft tissue sarcomas has increased the need for accurate pre-operative assessment of the primary tumour. Tumour site, extent and relationship to bone and neurovascular structures determine whether adequate radical surgery is feasible or whether more limited excision as a part of multimodality treatment is appropriate. Pre-operative computed tomography (CT) was compared with operative findings in 38 patients with soft tissue sarcomas. CT prediction of muscle group involvement by tumour was correct in 95 per cent and prediction of major artery or vein invasion was correct in 92 per cent and 97 per cent respectively. Assessment of tumour relationship to major peripheral nerve was accurate for thigh sarcomas but was not possible in upper limb tumours. While CT confirmed frank bony involvement in two patients, it failed to distinguish between tumours closely adjacent to periosteum and those with periosteal invasion. Detection of residual or recurrent tumour nodules is less reliable; CT is most accurate before any surgical intervention.

Adolescent↗