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C Papagno

Publications and source records attributed to C Papagno.

At least 19 recordsLinked to original sources
PubMed2003

Memory and executive functions in aneurysms of the anterior communicating artery.

The cognitive outcome of three groups of patients, who had undergone surgery for repair of a single ruptured intracranial aneurysm, was evaluated. We assessed performance on tests of executive functions and memory in a group of 15 patients tested at least 3 months after an aneurysm of the anterior communicating artery (ACoA) and in a group of 12 patients tested in the first month after the same pathology. Acute patients were more impaired overall than chronic ones, but the two groups significantly differed on two executive and one memory test. The performance of the ACoA patients was also compared to the performance of a group of 10 patients who had undergone surgery for an aneurysm located on the posterior communicating artery (PCoA) at least 3 months before the examination. Chronic ACoA and PCoA patients significantly differed in two memory and in two executive tests performance, with posterior patients being more impaired than anterior. An unexpected finding was the impairment of semantic memory in ACoA patients.

Adult↗
PubMed2002

Famous face recognition and naming test: a normative study.

Tests of famous face recognition and naming, and tasks assessing semantic knowledge about famous people after presentation either of their faces or their names are often used in the neuropsychological examination of aphasic, amnesic and demented patients. A total of 187 normal subjects took part in this study. The aim was to collect normative data for a newly devised test including five subtests: famous face naming, fame judgement after face presentation and after name presentation, semantic knowledge about famous people after face presentation and after name presentation. Norms were calculated taking into account demographic variables such as age, sex and education and adjusted scores were used to determine inferential cut-off scores and to compute equivalent scores. Multiple regression analyses showed that age and education influenced significantly the performance on most subtests, but sex had no effect on any of them. Scores of the subtest evaluating fame judgements after name presentation were significantly influenced only by education. The only subtest whose scores were not influenced by any demographic variable was fame judgement after face presentation.

Adult↗
PubMed2001

Slowly progressive aphasia: a four-year follow-up study.

This paper reports the long-term follow-up of GC, a patient with primary progressive aphasia of the fluent type. GC presented at onset with an anomia characterized by sparing of first letter knowledge, that applied mainly to proper names and living categories. No semantic deficits were observed in the first stage of the disease, and MRI showed a left temporal lobe atrophy with a gradient from the pole to the posterior regions, the latter being less involved. We now report the clinical evolution of GC from the 2nd to the 4th year of disease. As the disease progressed, the anomia became more severe and the phenomenon of first letter sparing was no longer detectable. Also semantic knowledge was gradually affected and, eventually, was dramatically lost. However, no other cognitive deficits were seen at the last examination. By that time, the temporal atrophy shown by MRI was bilateral, although still more evident on the left side.

Aphasia, Primary Progressive↗
PubMed2001

Understanding metaphors and idioms: a single-case neuropsychological study in a person with Down syndrome.

The ability of subject F.F., diagnosed with Down syndrome, to appreciate nonliteral (interpreting metaphors and idioms) and literal (vocabulary knowledge, including highly specific and unusual items) aspects of language was investigated. F.F. was impaired in understanding both metaphors and idioms, while her phonological, syntactic and lexical-semantic skills were largely preserved. By contrast, some aspects of F.F.'s executive functions and many visuospatial abilities were defective. The suggestion is made that the interpretation of metaphors and idioms is largely independent of that of literal language, preserved in F.F., and that some executive aspects of working memory and visuospatial and imagery processes may play a role.

Adult↗
PubMed2001

Comprehension of metaphors and idioms in patients with Alzheimer's disease: a longitudinal study.

Language in patients with Alzheimer's disease has been extensively studied, with the exception of non-literal language comprehension. However, in our speech, we often make use of expressions, which are not necessarily interpreted on a literal ground. Comprehension of metaphors and idioms was examined in 39 patients with probable early Alzheimer's disease. The results showed that the decline of figurative language is not an early symptom of dementia and can occur independently from the impairment of propositional language. It was also found that metaphors and idioms differ as far as the predominant kind of error is concerned.

Aged↗
PubMed2000

The selective impairment of phonological processing in speech production.

We report the naming performance of a patient (DM) with a fluent progressive aphasia who made phonological errors in all language production tasks. The pattern of errors in naming was strikingly clear: DM made very many phonological errors that resulted almost always in nonword responses. The complete absence of semantic errors and the very low ratio of formal errors relative to nonword errors (1.6:30.3) in DM's performance are discussed in the context of recent claims about the nature of naming deficits in fluent aphasics. We argue that DM's performance makes highly improbable the claim that fluent aphasia results from global lesions affecting all levels of the lexical access system equally.

Aged↗
PubMed2000

Upper and lower face apraxia: role of the right hemisphere.

The aim of this study was to evaluate face apraxia in left- and right-hemisphere-damaged patients both in the acute and chronic stage of their disease. Two newly devised tests that assess movements of the upper and lower face districts were employed. On the whole, the proportion of left-hemisphere-damaged patients showing face apraxia were 46 and 68% for upper and lower face, respectively. A substantial proportion of right-hemisphere-damaged patients also showed face apraxia, i.e. 44% upper face and 38% lower face. Concomitant variables such as general severity, locus of lesion, language or visuo-spatial impairments, presence of neglect, interval from stroke, peculiarity of clusters of items or scoring procedures did not account for these results. These findings suggest that face apraxia in some patients may affect movements of the upper face district and that the right hemisphere plays a significant part in both upper and lower face praxis.

Adult↗
PubMed1999

Naming people ignoring semantics in a patient with left frontal damage.

Studies about proper name anomia generally assume that persons' names are harder to recall than other semantic information one knows about them and that name retrieval is not possible without biographical knowledge. We describe a patient, SB, who, after a left frontal haemorrhage, was unable to recall any biographical information about people she could name. Moreover, she had a normal score in an Object Picture Naming Test, but gave confabulatory answers in a Semantic Questionnaire involving the same items. The role of frontal function in producing this pattern of impairment is discussed, together with the possible existence of a direct route from visual perception to proper name retrieval.

Aged↗
PubMed1998

Transient retrograde amnesia associated with impaired naming of living categories.

A ease of pure retrograde amnesia following mild head injury is reported. The patient, who also showed a deficit in verbal fluency and a living/non-living dissociation in naming during the amnesic period, recovered progressively in about ten days post-trauma. Both a psychogenic and an organic origin could be taken into account. A mechanism (no matter if psychogenic or organic) can be hypothesized, which produces a functional inhibition also involving performances that are unlikely to be affected by psychological factors.

Adult↗
PubMed1998

Proper name anomia: a case with sparing of the first-letter knowledge.

In this article we describe the case of GC, a woman affected by severe proper name anomia due to progressive brain atrophy that mainly affected the left temporal pole. Proper name comprehension and semantic knowledge about the people she was unable to name were normal. GC showed a sparing of initial letter knowledge of proper names, while other phonological characteristics were not equally available. At a later stage of her illness, the naming impairment began to affect common names as well as proper names, though at a lesser extent. Whereas there was no category effect between names of animate and inanimate stimuli, we observed a relative sparing of first letter knowledge selectively for animate categories, although less marked than with proper names. This case is discussed within the theoretical framework of two-stage models of name production. Knowledge of the initial letter of proper names supports the psychological reality of the "phonological address" as a preliminary stage of the production of this class of names. Moreover, the qualitative similarity between errors observed with proper names and with names of animate objects suggests that the production of names belonging to these classes may conform, at least in part, to analogous algorithms.

Anomia↗
PubMed1998

The phonological loop as a language learning device.

A relatively simple model of the phonological loop (A. D. Baddeley, 1986), a component of working memory, has proved capable of accommodating a great deal of experimental evidence from normal adult participants, children, and neuropsychological patients. Until recently, however, the role of this subsystem in everyday cognitive activities was unclear. In this article the authors review studies of word learning by normal adults and children, neuropsychological patients, and special developmental populations, which provide evidence that the phonological loop plays a crucial role in learning the novel phonological forms of new words. The authors propose that the primary purpose for which the phonological loop evolved is to store unfamiliar sound patterns while more permanent memory records are being constructed. Its use in retaining sequences of familiar words is, it is argued, secondary.

Adolescent↗
PubMed1997

Confabulation in a dysexecutive patient: implication for models of retrieval.

A confabulating patient MM is described who, despite clear evidence of a dysexecutive syndrome, showed normal prospective and retrospective memory in everyday life and preserved autobiographical memory. He also performed well on many, but not all laboratory-based measures of learning and memory that were given. His confabulation typically involved going well-beyond the information he could genuinely recall, and was attributed to a defect in memory monitoring resulting from his frontal lobe damage. Implications for the role of "stop rules" in memory retrieval are discussed.

Adult↗
PubMed1997

Dual-task performance in dysexecutive and nondysexecutive patients with a frontal lesion.

Patients with defined frontal lobe lesions were assigned to 1 of 2 groups based on whether they showed a behaviorally assessed dysexecutive syndrome or were behaviorally normal. All participants were tested on dual-task performance and on 2 tasks assumed to measure frontal lobe function, the Wisconsin Card Sorting Test and verbal fluency. The dysexecutive group differed significantly from the nondysexecutive in showing impaired capacity for dual-task coordination, but there were no significant differences on the Wisconsin Card Sorting Test and verbal fluency. Results are interpreted in terms of a multicomponent central executive, whose function is linked to, but not coterminous with, the operation of the frontal lobes.

Adult↗
PubMed1997

Transcallosal approach to tumors of the third ventricle. Surgical results and neuropsychological evaluation.

A series of 34 patients with tumours of the third ventricle were operated on by a transcallosal route. Basal extrinsic lesions compressing or invading the ventricle as well as tumours located in the pineal area were excluded from this review. Tumours were approached by a transforaminal entry in 16 cases (47%), by an interforniceal route in 11 (32%), by a subchoroidal entry in 4 (14%) and by a combined transforaminal and subchoroidal entry in 3 (9%). Four out of 34 patients were submitted to a second operation, through the same approach corridor: 2 for an incomplete removal of an intrinsic tumour and 2 for a late regrowth. Postoperative mortality rate accounted for 5.8% (2 patients). Major post operative complications were hemiparesis (4 patients) and diabetes insipidus (4 patients), that were transient in 3. Akinetic mutism like status was observed in only 1 patient. Postoperative psychic disturbances were noticed in 5 cases. Nine out of 21 patients (62%) with preoperative hydrocephalus required a permanent CSF shunt. Histology revealed that 21 tumours (62%) were intraaxial (4 pilocitic astrocytoma, 10 low grade glioma, 1 giant cell astrocytoma, 1 subependymoma, 4 ependymoma/ependymoblastoma, 1 neurocitoma) and 13 (38%) were extraaxial (8 colloid cyst, 2 craniopharingioma, 1 ectopic pituitary adenoma, 1 lymphocytic hypophysitis and 1 metastasis). Total excision of third ventricle tumours was achieved in all patients with extraaxial tumours and in 62% and 71% of intraaxial tumours with the first and second surgical procedure respectively. Ten out of 34 patients of this series were submitted to a complete neuropsychological evaluation at an interval of 2-9 years after surgery. Memory tests were pathological in 2. Disconnection signs were constantly absent. Control function were preserved. Transcallosal approach remains the best microsurgical method of third ventricle tumours treatment. This route provides the capability for a superior visualization of the entire cavity of the third ventricle through different corridors. Permanent neurological and neuropsychological deficits are not frequent. Epilepsy, that accounted for 28% in patients submitted to transcortical transventricular approach to third ventricle tumours, was never noticed in this series operated on through a transcallosal route.

Adolescent↗
PubMed1996

Perseveration in two aphasic patients.

In this paper we report the perseverative behavior of two aphasic patients, AB and MT. They were submitted to a standardized Language Examination and to verbal and nonverbal tasks designed to elicit perseveration. Some of the features pointed out in the literature were not confirmed. Perseveration was not semantically related to the target; a correct response did not have any special status; in many instances the perseveration had not been produced as a correct response and could reappear immediately or after many stimuli; the production of two consecutive correct responses did not inhibit the spontaneous recurrences and could again be followed by the perseveration of a previous wrong response. Perseveration did not set in in the same circumstances for the two patients: in AB it set in when the patient was unable to find the correct response; MT, on the contrary, while knowing the correct response, was unable to change her perseverative behavior from one response to the other. For both patients, however, it seems as if no inhibitory system stops pre-existing motor or verbal behavior.

Adult↗
PubMed1995

Improvement of left visuo-spatial hemineglect by left-sided transcutaneous electrical stimulation.

The effects of transcutaneous electrical stimulation on left visuo-spatial hemineglect, assessed by a visuo-motor exploratory task (letter cancellation), were investigated in patients with right hemisphere lesions. In Experiment 1 left neck stimulation temporarily improved the deficit in 13 out of 14 patients (93%), while stimulation of the right neck had no positive effects, worsening exploratory performance in nine patients (64%). Experiment 2 showed that left neck stimulation temporarily improved neglect also when head movements were prevented by a chin-rest. In Experiment 3, stimulation of both the left hand and left neck had comparable positive effects on visuo-spatial hemineglect. These results are interpreted in terms of: (1) non-specific activation of the right hemisphere, contralateral to the stimulation side; (2) specific directional effects of left somatosensory stimulation on the egocentric co-ordinates of extra-personal space, which in neglect patients are distorted towards the side of the brain lesion.

Adult↗