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Biomedical subjects

C Papageorgiou

Publications and source records attributed to C Papageorgiou.

At least 73 records · Page 4Linked to original sources
PubMed1995

Worry and the incubation of intrusive images following stress.

This study investigated the effects of post-event processing on intrusive images following exposure to stress. It was hypothesized that ruminative activity, especially verbal worry about a stressor leads to an incubation of intrusions. Five groups which differed in the use of post-event processing strategies were used to test for a hypothesized co-joint mechanism underlying the effect. Worrying about a stressor for a period of 4 min after exposure led to significantly more intrusions in the next 3 days than a settle-down control condition. The strategies of imaging about the stressor, distraction, and worrying about usual concerns, produced a significant incremental linear pattern of intrusions across these groups. The pattern of results was as predicted by a co-joint model in which incubation results from 'tagging' of memories and blocked emotional processing. The clinical implications of these findings are briefly discussed.

Adolescent↗
PubMed1995

Exclusion mapping of the benign hereditary chorea gene from the Huntington's disease locus: report of a family.

A Greek family is presented in which seven members suffered from benign hereditary chorea (a rare autosomal dominant non-progressive chorea without dementia). All patients and three informative healthy relatives were submitted to DNA analysis using probes from loci linked to Huntington's disease. The results confirm one previous suggestion that these two disorders are not allelic and that they should be considered as two distinct genetic entities.

Adolescent↗
PubMed1995

Linkage disequilibrium between the expanded (CAG)n repeat and an allele of the adjacent (CCG)n repeat in Huntington's disease patients of Greek origin.

Huntington's disease (HD) is associated with an expanded unstable (CAG)n repeat in the IT15 gene. This repeat was investigated in 44 HD patients and 59 of their relatives at risk who were members of 29 unrelated families from various parts of Greece. Abnormal elongation of the (CAG)n repeat ranging from 39 to 95 trinucleotide units was found in all but one of the 44 HD patients tested with 70% of these patients showing 42-47 repeats. The size of the expanded sequence correlated inversely with the age at disease onset (r = 0.77, p < 0.00001, n = 43). In a single sporadic case, de novo expansion of the (CAG)n repeat was detected. Twenty-four of 59 asymptomatic family members at risk showed expansion of the (CAG)n repeat in the HD range (39-56 trinucleotide units) while three had intermediate alleles (36-37 repeats). Evaluation of the adjacent polymorphic (CCG)n repeat showed a strong linkage disequilibrium between the 7-unit (CCG)n repeat allele and the HD mutation, with 51% of normal and 93% of HD chromosomes showing this allele (chi 2 = 15.55, p < 0.0001, n - 260). These data on HD patients of Greek origin are consistent with the thesis that the (CAG)n expansion is the primary gene defect of the disease and that this mutation occurred primarily on chromosomes with the (CCG)7 repeat haplotype.

Age of Onset↗
PubMed1995

Application of silicon tissue expanders for the direct or indirect coverage of soft tissue defects in the extremities.

In a 2 year prospective study, 17 tissue expanders were placed on the extremities of 17 patients. The aim was to cover soft tissue defects in the forearm of 8 patients after chinese flap dissection, which was used either as a free or reversed flap. In 8 of the remaining patients, the expanded skin was placed directly on the affected region as a local fasciocutaneous flap. In 1 patient it was determined intra-operatively that the prepared extended skin was not necessary to treat the patient. The tissue expander was successfully used to cover skin defects, both directly and indirectly, in the lower extremity (7 cases) and in the upper extremity (9 cases). Neither infection nor necrosis was observed in the flaps and the cosmetic results, particularly in the forearm, were satisfactory.

Adolescent↗
PubMed1995

Gadopentetate dimeglumine-enhanced MR in the diagnosis of the Tolosa-Hunt syndrome.

A 54-year-old man first was admitted with a right oculomotor nerve palsy that ameliorated spontaneously. Two months later, he was readmitted with right proptosis, ophthalmoplegia, and optic nerve involvement. MR showed an enlarged right cavernous sinus. There was dramatic improvement after high doses of steroids. MR findings 10 months later were normal. Thus, the diagnosis of the Tolosa-Hunt syndrome was established.

Cavernous Sinus↗
PubMed1995

Raeder's syndrome. Report of two cases.

Raeder's syndrome constitutes facial pain and ipsilateral stenosis of the palpebral fissure, miosis and enophthalmos. It is divided into two groups. Group I includes cases with parasellar cranial nerve involvement and group II without parasellar cranial nerve involvement. It is often difficult to distinguish group II of Raeder's syndrome from Horner's syndrome. The latter is painless and is accompanied by anidrosis of the ipsilateral half of the face. In fact Raeder's syndrome may be caused by any lesion affecting the post-ganglionic oculosympathetic fibers distal to the bifurcation of the common carotid artery. Serious lesions of the internal carotid artery (ICA) may be responsible for this syndrome. This paper deals with two cases of group II of Raeder's syndrome. In the first case, a 60-year-old man, the angiogram revealed an aneurysm of the extracranial part of the ICA just below its entrance into the calvarium. In the second case, a 42-year-old man, a dissective aneurysm of the ICA was found. Surgery was not attempted in either of our patients for different reasons. Their symptoms ameliorated quickly with medical treatment.

Adult↗
PubMed1994

An epidemiological study of headache among the Monks of Athos (Greece).

The Monks of Athos in Greece constitute a particular group with unusual sleep schedule and specific diet. In order to study the frequency of headache among them, a special questionnaire was designed. Four hundred forty-nine monks below the age of 50 were approached, 39 of whom suffered from frequent (more than one episode per month, in the last 6 months) headaches (8.68%). The prevalence of migraine was 1.78% (0.66% with aura and 1.11% without) and of tension-type headache 3.34% (1.33% chronic and 2% episodic). Furthermore, 1.87% of monks suffered from mixed headaches (tension-type and migraine attacks as well). Cluster headache was not traced.

Adult↗
PubMed1992

Cognition in relapsing-remitting multiple sclerosis: a multichannel event-related potential (P300) study.

Auditory event-related potentials (AERP) were elicited in 47 patients with relapsing-remitting (RR) multiple sclerosis (MS) and 24 age-matched controls. MS patients had significantly prolonged N2 and P3 latencies as well as low P3 amplitude compared with controls. Seven of them exceeded 3 standard deviations from the control mean values. The observed N2 and P3 alterations are associated with the patients' disability status as it is defined by the Kurtzke expanded disability status scale (EDSS), but are not related to the duration of the disease. A possible cognitive decline as reflected in the observed AERP components alterations in MS patients is subsequently discussed.

Adult↗
PubMed1992

Cognition in epilepsy: a multichannel event related potential (P300) study.

Auditory event-related potentials (AERP) were elicited in 68 epileptic patients and 30 age-matched controls. Epileptic patients had significantly prolonged N2 and P300 (P3) latencies compared with controls. Seven patients were above the range of 3 standard deviations from the control mean values. Amongst epileptics, patients with temporal lobe epilepsy had significantly prolonged P3 latencies compared to patients with idiopathic generalized epilepsy. Patients with abnormal EEGs had significantly prolonged P3 latencies compared to those with normal EEGs. Patients on anticonvulsant monotherapy had shorter P3 latencies, compared to patients taking a combination of two or more anticonvulsants. Patients on shorter duration of treatment had less prolonged P3 latencies compared to those on longer anticonvulsant treatment.

Adolescent↗
PubMed1992

Serum anti-GM1 and anti-GD1a antibodies in patients with motor neuron disease.

Using an enzyme-linked immunosorbent assay (ELISA) sera from 100 individuals, 20 with motor neuron disease (MND), 25 with peripheral neuropathy (PN), 15 with degenerative dementia and 40 controls, were examined in order to detect serum IgM and IgG anti-GM1 and anti-GD1a antibodies. Patients with MND showed statistically significant higher levels of IgM anti-GM1 antibody compared to the control group. Three patients with peripheral neuropathy had very high levels of anti-GM1 and anti-GD1a antibodies. Antibody levels in patients with degenerative dementia showed no difference compared to the controls. These results suggest that a further inquiry into the role of serum anti-GM1 and anti-GD1a activity in motor neuron disease and peripheral neuropathy is necessary.

Aged↗
PubMed1991

Cortical potentials preceding centrifugal and centripetal self-paced horizontal saccades.

Cortical potentials preceding self-paced centrifugal and centripetal saccades were recorded in 15 subjects from F3, Fz, F4, C3, Cz, C4, P3, Pz and P4 versus linked mastoid electrodes. A negative potential starting about 1.0 sec prior to saccade onset, reaching a peak amplitude of 6.8 microV on average, preceded centrifugal saccades. In contrast the negativity preceded centripetal saccades by only 500 msec, and its peak amplitude was smaller (4.6 microV). We conclude that these differences reflect the fact that less 'effort' is needed with centripetal as compared to centrifugal saccades.

Adult↗
PubMed1991

Neurophysiological and neuro-otological study of homozygous beta-thalassemia under long-term desferrioxamine (DFO) treatment.

This report presents data on visual evoked potentials (VEPs) and brainstem auditory evoked potentials (BAEPs), as well as neurologic, ophthalmologic and otologic assessments performed on 120 patients with beta-thalassemia major undergoing long-term DFO treatment. A total of 32 patients showed abnormal VEPs and 14 abnormal BAEPs; seven had both VEP and BAEP abnormalities; 12 had sensorineural hearing loss (SNHL); 18 had conductive hearing loss, while 14 showed a combination of SNHL and conductive hearing loss. After DFO administration was modified (taking in consideration the serum ferritin levels) patients with abnormal findings were retested. The values of 15 patients of 23 who underwent VEP examinations had been normalized. Eleven of 15 who repeated the BAEP test had also gained normal values. The audiogram had not returned to normal in any patient with SNHL. In a second repetition of the examinations, no change was observed. It is concluded that in a great percentage of thalassemics at least one of the above examinations shows abnormal values. These abnormalities are mostly reversible, and probably reflect a dysfunction of the visual or auditory system, due either to DFO neurotoxicity or to iron overload or both.

Adult↗
PubMed1991

Amyotrophic lateral sclerosis in southern Greece: an epidemiologic study.

All amyotrophic lateral sclerosis cases hospitalized over a 25-year period in the University Department of Neurology in Athens were surveyed, with emphasis given to the occupation of the patients and the geographic distribution of the disease. The results showed an overrepresentation of farmers among patients and an aggregation of cases in the region of Cephalonia. These findings might suggest that environmental factors could be involved in the etiology of the disease.

Adult↗