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Biomedical subjects

C Pandolfi

Publications and source records attributed to C Pandolfi.

At least 19 recordsLinked to original sources
PubMed1992

[Asymptomatic bilateral occipital calcifications. A possible atypical form of Sturge-Weber-Krabbe syndrome?].

Sturge-Weber-Krabbe syndrome is a rare congenital neuro-cutaneous disease which is characterized, in its full clinical expression, by facial naevus flammeus and epilepsy with mental retardation. Different atypical cases in which one or more symptoms are missing and clinical course is benign, have been reported in the literature in recent years. In the present paper a possible case of this syndrome radiologically diagnosed, without neurological and cutaneous symptoms, is reported; the importance of a more comprehensive study of this complex disorder, with particular attention to the incomplete forms, is stressed.

Adult↗
PubMed1991

[Platelet aggregation during adjuvant chemotherapy with CMF].

We have studied platelet aggregation in fourteen pre- and post-menopausal women treated with cyclic adjuvant CMF chemotherapy for mammary cancer with positive axillary nodes, previously operated. Aim of the investigation is to evaluate the effect of chemotherapy on platelet aggregation. The obtained results demonstrate that CMF therapy does not modify platelet aggregation in both pre- and post-menopausal patients.

Adenocarcinoma↗
PubMed1991

[Prognostic significance of hypereosinophilia in surgically treated breast carcinoma. Our experience].

Several Authors have published that hypereosinophilia is often related to solid carcinoma and mostly to mucin secreting epithelium carcinoma. Such hypereosinophilia has been considered a negative prognostic symptom. In this trial we have studied our out-patients affected by breast cancer who showed hypereosinophilia during their post-surgical follow-up or therapy. Such hypereosinophilia was not related to any symptom of progression of neoplasia. We thus suppose that hypereosinophilia associated with breast cancer is probably not related to the development of neoplastic tissue.

Adult↗
PubMed1991

[Carcinoembryonic antigen (CEA) and mucinous-like tumor associated antigen (MAC). Statistic correlation in advanced breast carcinoma].

In this study we have determined the plasmatic values of carcinoembryonic antigen (CEA) and mucinous like tumor associated antigen (MCA) in 20 women with metastatic breast cancer. CEA and MCA were determined by enzyme immunoassay technique. The results were analyzed by test r for the statement of statistical correlation. Since r was inferior to p 5% (r = 0.3255; p = 0.4438) the 2 parameters are not correlated and their biological expression must be considered independent.

Adult↗
PubMed1990

[Primary amyloidosis. A case report].

Primary amyloidosis is an uncommon disease which can be considered a diagnostic challenge. A recently observed case, initially characterized by peripheral neuropathy and subsequently by heart failure and sudden death, is described.

Aged↗
PubMed1989

[Chronic lymphatic leukemia with cerebral localization. A case report].

Central nervous system (C.N.S.) involvement is present in 20% of leukemic patients, while it accounts for only 2% of primary extranodal localizations of malignant lymphoma (M.L.). A clinical case in which a neurological syndrome is the opening symptom of chronic lymphatic leukemia (C.L.L.) is described.

Aged↗
PubMed1988

[Primary malignant lymphomas of the gastrointestinal system].

The Authors describe their experience regarding eight cases of primary malignant gastrointestinal lymphomas. After having briefly reexamined the epidemiology and the problems coming from the discordances that still exist on various systems of classification and of staging, they put in evidence that it is not always possible to reach a sure preoperative diagnosis on such pathology, and they explain some considerations about the diagnosis, the therapy and the prognosis.

Aged↗
PubMed1986

[Surgical and postsurgical therapy of differentiated carcinomas of the thyroid].

Surgical removal of the gland has been for a long time an essential tool in the therapy of differentiated thyroid carcinomas. Radical or conservative operation is discussed in the surgical management of thyroid carcinoma. In all cases main risk factors must be considered: age, sex and tumour extension. I131 therapy is prescribed in the treatment of functioning metastasis of patients after total thyroidectomy. Substitutive hormonotherapy must also suppress TSH secretion.

Carcinoma↗
PubMed1986

[Differentiated carcinoma of the thyroid gland. Anatomo-clinical characteristics].

Differentiated carcinomas of the thyroid constitute a broad group of tumours with different biological and epidemiological aspects. They are still a challenge to the pathologist: a correct definition of the histological type can give in fact important indications for prognosis, therapy and follow-up. The nosological settlement of these tumours has been questioned by recent studies which have described traits of medullary and anaplastic carcinomas. Their prognosis is good on the whole, but notwithstanding their rarity, they show various biological and histological aspects which still have to be better clarified.

Adenocarcinoma↗
PubMed1986

[Postoperative follow-up in differentiated carcinoma of the thyroid gland].

Serial serum thyroglobulin determinations and 131I whole body scans are the main diagnostic tools in the follow-up study of patients with treated differentiated thyroid cancer. A thyroglobulin level below 1 ng/ml during suppressive therapy is unsuspicious . In two thirds of patients there is discordance of iodide trapping and thyroglobulin secretion: thyroglobulin assay can't therefore be used as a predictive index of radioiodine uptake.

Adenocarcinoma↗
PubMed1986

[Lymphoma of the thyroid (description of 2 cases)].

Primary lymphoma of the thyroid is a rare disease and it occurs in a low percentage of thyroid tumours. Nevertheless its frequency is increasing. We present two observed cases in this study. One of these is an exceptional extra-nodal localization of Burkitt's lymphoma. The role of surgery in these particular neoplasms and the importance of intraoperative histological examination for the rational therapeutic behaviour are stressed.

Burkitt Lymphoma↗
PubMedDate not supplied

[Osteocalcin and hyperthyroidism].

Osteoporosis may be induced by hyperthyroidism through an increase of bone turnover, because bone resorption exceeds formation in this condition. Also therapy with 1-thyroxine, especially by TSH-suppressive doses, may induce a reduction in bone mineral content. Circulating osteocalcin (sBGP) significantly increases both in endogenous and exogenous hyperthyroxinemia and is considered a reliable non invasive marker of bone turnover. In this study an extra-increase of sBGP in hyperthyroid post-menopausal women towards pre-menopausal is reported, the persistence of high sBGP levels in patients affected by any type of hyperthyroidism after four months of therapy and a positive relationship with thyroid hormones (fT4). Therefore monitoring of this serum marker may be suggested also in patient chronically treated with 1-thyroxine to avoid, if possible, overzealous therapy.

Adult↗
PubMedDate not supplied

[Association of hyperthyroidism and diabetes mellitus. Description of a case with partial recovery of pancreatic beta-islet function].

The coexistence of Graves' disease and insulin-dependent diabetes mellitus is well known among autoimmune polyglandular syndromes and sustained by common underlying immune pathogenic factors. Hyperthyroidism itself may lead to impaired glucose tolerance in subjects with intact beta-cell function through various not well clarified mechanisms and treatment of thyroid hyperfunction, on the other side, generally ameliorates the degree of metabolic control when diabetes is pre- and/or coexisting. We report a case of Graves' disease associated with diabetes mellitus, in which a partial recovery of insulin secretion is documented after euthyroidism was restored.

Autoimmune Diseases↗
PubMedDate not supplied

[Thyrotoxic periodic paralysis and Graves' disease. Description of an HLA-CW7-positive case].

Thyrotoxic periodic paralysis is an uncommon complication of hyperthyroidism, more frequent in Oriental populations and in male than in female subjects. Electron microscopic investigations have shown characteristic degenerative changes of muscle fiber. In this study the sequence of pathophysiologic events proposed by the literature is illustrated and a case of thyrotoxic periodic paralysis in a HLA-CW7 positive patient affected by Graves' disease is reported.

Adult↗