Biomedical subjects
C Pallis
Publications and source records attributed to C Pallis.
Brainstem death: the evolution of a concept.
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Brain stem death--the evolution of a concept.
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Diabetes insipidus with brain death.
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Acromegaly and narcolepsy.
7 of 372 acromegalic patients had troublesome episodes of paroxysmal daytime sleep. Although 3 patients had complete remission of symptoms within a few days of pituitary implantation of isotopes, the cause of this increased frequency of narcolepsy among acromegalic patients is not known.
Morphological and biochemical findings in jejunal biopsies from patients with multiple sclerosis.
Gluten withdrawal from the diet is occasionally used speculatively in the management of multiple sclerosis. To assess whether there might be any rational basis for such a measure we have undertaken morphological and biochemical studies of the jejunal mucosa in 14 patients with multiple sclerosis. All were found to have morphologically normal villi, and quantitative estimation of surface-to-volume ratios gave values which did not differ from control subjects. Intraepithelial lymphocyte counts were normal. Antigliadin antibody titres were not raised in any patient. Estimation of activity of the brush border disaccharidases (sucrase, lactase, and maltase (showed that the mean level of each enzyme did not differ significantly from control subjects. Analytical subcellular fractionation of the biopsies showed no changes in the distribution or activity of marker enzymes for the brush order, lysosomes, mitochondria, cytosol, peroxisomes, or endoplasmic reticulum. It is concluded that there are no gross morphological or biochemical abnormalities in the jejunal mucosa in patients with multiple sclerosis and, therefore, that the use of gluten-free diets cannot be justified on the assumption that these patients suffer from a coeliac-like lesion of the small intestine.
Treatment of acute polyneuropathy by plasma exchange.
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Idiopathic orthostatic hypotension. Report of an autopsied case with histochemical and ultrastructural studies of the neuronal inclusions.
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"Myopathy" with tubular aggregates.
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Reversible nicotinamide-deficiency encephalopathy in a patient with jejunal diverticulosis.
A patient with severe malabsorption due to massive diverticulosis of the small intestine developed an acute encephalopathic syndrome which responded dramatically to intravenous nicotinamide. Various mechanisms are discussed whereby nicotinamide deficiency might have occurred in this clinical context.