Search PubMedSearch

Biomedical subjects

C P Olinger

Publications and source records attributed to C P Olinger.

6 recordsLinked to original sources

Ultrasonic B-scan echoarteriographic imaging of experimentally induced thrombi in dogs.

Ultrasonic echoarteriography is a noninvasive method of visualizing extracranial arteries in health and disease. The real-time echoscanning device developed at the University of Cincinnatti utilizes a 5-MHz (center frequency) pulse-echoimaging system. B-mode pictures of the tissues studied are obtained and displayed on a video screen, real-time operation being provided by the scanning mechanism operating at 30 frames per second. In our experiments internal arterial damage produced by surgically scraping the intima induced experimental thrombosis in nine carotid in nine carotid and three femoral arteries in dogs. Where pathologically demonstrated, the thrombi were demonstrated by ultrasonic echoarteriography in every instance. Echoarteriography seemed more sensitive than contrast arteriography in the detection of a partially occlusive thrombus.

Animals

Electronic stethoscope for detection of cerebral aneurysm, vasospasm and arterial disease.

A specially designed acoustic stethoscope electronic-computer-analysis system has repeatedly detected and identified angiographically demonstrated anteriorly located intracranial aneurysms by their characteristic signals. The system has detected and measured clinically significant disease in the carotid siphon and bifurcation, even in cases with normal angiograms, and has recorded the onset and disappearance of cerebral vasospasm. Our data suggests that an aneurysm may act as a flexible Helmholtz resonator, possibly being driven by vortex shed or turbulence. Our goal is the development of a safe, non-invasive method by which the physician could investigate warning symptoms of aneurysms, cerebral vasospasm, and arterial disease in order to recommend preventive surgery or medical treatment early before the patient's condition might deteriorate. Individual cases, falsely positive and negative results are discussed.

Adult

Carotid artery endoscopy (autopsy).

Intra-arterial endoscopy of the common carotid artery and its bifurcation was accomplished in 100 random autopsy cases. Resulting still photographs and movies reveal fatty dots and streaks, elevated gelatinous plaques, mural thrombi, thrombosis, ulcerations and ulcers with or without organizing thrombi, boulder and stalagmite-shaped lesions, bridging and elevated plaques in the carotid artery. These findings suggest possible explanations for some surgical and angiographic complications, bruits, transient ischemic attacks or strokes following reportedly normal carotid angiograms. Endoscopy aids in understanding the theories of inception, progression and sequelae of atherosclerosis,the role of risk factors, trauma and hemodynamics.

Arteriosclerosis

Possible prevention of brain stem stroke by microvascular anastomosis in the vertebrobasilar system.

Four patients with symptoms and signs of brain stem ischemia due to occlusive disease of the vertebrobasilar system and one patient with similar cerebrovascular disease who was thought to be prone to brain stem stroke underwent a microvascular anastomosis between the occipital artery and the caudal loop of the posterior inferior cerebellar artery. There was no morbidity of mortality and neurologically all patients improved. Post-operative angiograms showed patent anastomosis in all the patients and improved circulation in three. This new operation may prove beneficial in a selected group of stroke patients who suffer from vertebrobasilar insufficiency and cannot be treated with gross surgical techniques.

Basilar Artery