Search PubMed⌕ Search

Biomedical subjects

C P Miles

Publications and source records attributed to C P Miles.

28 records · Page 2Linked to original sources

Phase contrast visualization of squamous cell microridges.

A successful attempt has been made to identify microridges on squamous cells in routine smears using phase contrast microscopy. Microridges may be identified on mature cells of buccal mucosa and in cervical smears, either alcohol or spray fixed, and even in smears up to five years old. The features identified with phase contrast may also be observed with scanning electron microscopy. Identification of microridges may be of diagnostic interest in the evaluation of cervical smears.

Cell Membrane↗

Microridges of neoplastic cervical cells. A phase-contrast study.

Fifty consecutive cervical smears representing dysplasia, carcinoma in situ or invasive cancer were examined by phase-contrast microscopy for the presence of cells with microridges. In a majority of cases, some neoplastic cells exhibited microridges. In more advanced neoplasias, the microridges were less frequent. The absence of microridges does not appear to be a characteristic of cancer per se but may be an indicator of the degree of squamous maturation of the cell.

Carcinoma, Squamous Cell↗