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Biomedical subjects

C P McKay

Publications and source records attributed to C P McKay.

At least 19 recordsLinked to original sources
PubMed2002

A wind origin for Titan's haze structure.

Titan, the largest moon of Saturn, is the only satellite in the Solar System with a dense atmosphere. Titan's atmosphere is mainly nitrogen with a surface pressure of 1.5 atmospheres and a temperature of 95 K (ref. 1). A seasonally varying haze, which appears to be the main source of heating and cooling that drives atmospheric circulation, shrouds the moon. The haze has numerous features that have remained unexplained. There are several layers, including a 'polar hood', and a pronounced hemispheric asymmetry. The upper atmosphere rotates much faster than the surface of the moon, and there is a significant latitudinal temperature asymmetry at the equinoxes. Here we describe a numerical simulation of Titan's atmosphere, which appears to explain the observed features of the haze. The critical new factor in our model is the coupling of haze formation with atmospheric dynamics, which includes a component of strong positive feedback between the haze and the winds.

Journal Article↗
PubMed2001

A possible nitrogen crisis for Archaean life due to reduced nitrogen fixation by lightning.

Nitrogen is an essential element for life and is often the limiting nutrient for terrestrial ecosystems. As most nitrogen is locked in the kinetically stable form, N2, in the Earth's atmosphere, processes that can fix N2 into biologically available forms-such as nitrate and ammonia-control the supply of nitrogen for organisms. On the early Earth, nitrogen is thought to have been fixed abiotically, as nitric oxide formed during lightning discharge. The advent of biological nitrogen fixation suggests that at some point the demand for fixed nitrogen exceeded the supply from abiotic sources, but the timing and causes of the onset of biological nitrogen fixation remain unclear. Here we report an experimental simulation of nitrogen fixation by lightning over a range of Hadean (4.5-3.8 Gyr ago) and Archaean (3.8-2.5 Gyr ago) atmospheric compositions, from predominantly carbon dioxide to predominantly dinitrogen (but always without oxygen). We infer that, as atmospheric CO2 decreased over the Archaean period, the production of nitric oxide from lightning discharge decreased by two orders of magnitude until about 2.2 Gyr. After this time, the rise in oxygen (or methane) concentrations probably initiated other abiotic sources of nitrogen. Although the temporary reduction in nitric oxide production may have lasted for only 100 Myr or less, this was potentially long enough to cause an ecological crisis that triggered the development of biological nitrogen fixation.

Atmosphere↗
PubMed2001

Use of spacecraft data to derive regions on Mars where liquid water would be stable.

Combining Viking pressure and temperature data with Mars Orbital Laser Altimeter topography data, we have computed the fraction of the martian year during which pressure and temperature allow for liquid water to be stable on the martian surface. We find that liquid water would be stable within the Hellas and Argyre basin and over the northern lowlands equatorward of about 40 degrees. The location with the maximum period of stable conditions for liquid water is in the southeastern portion of Utopia Planitia, where 34% of the year liquid water would be stable if it were present. Locations of stability appear to correlate with the distribution of valley networks.

Journal Article↗
PubMed2001

Production of nitrogen oxides by lightning and coronae discharges in simulated early Earth, Venus and Mars environments.

We present measurements for the production of nitrogen oxides (NO and N2O) in CO2-N2 mixtures that simulate different stages of the evolution of the atmospheres of the Earth, Venus and Mars. The nitrogen fixation rates by two different types of electrical discharges, namely lightning and coronae, were studied over a wide range in CO2 and N2 mixing ratios. Nitric oxide (NO) is formed with a maximum energy yield estimated to be ~1.3 x 10(16) molecule J-1 at 80% CO2 and ~1.3 x 10(14) molecule J-1 at 50% CO2 for lightning and coronae discharges, respectively. Nitrous oxide (N2O) is only formed by coronae discharge with a maximum energy yield estimated to be ~1.2 x 10(13) molecule J-1 at 50% CO2. The pronounced difference in NO production in lightning and coronae discharges and the lack of formation of N2O in lightning indicate that the physics and chemistry involved in nitrogen fixation differs substantially in these two forms of electric energy.

Atmosphere↗
PubMed2001

Solid organic matter in the atmosphere and on the surface of outer Solar System bodies.

Many bodies in the outer Solar System display the presence of low albedo materials. These materials, evident on the surface of asteroids, comets, Kuiper Belt objects and their intermediate evolutionary step, Centaurs, are related to macromolecular carbon bearing materials such as polycyclic aromatic hydrocarbons and organic materials such as methanol and related light hydrocarbons, embedded in a dark, refractory, photoprocessed matrix. Many planetary rings and satellites around the outer gaseous planets display such component materials. One example, Saturn's largest satellite, Titan, whose atmosphere is comprised of around 90% molecular nitrogen N2 and less than 10% methane CH4, displays this kind of low reflectivity material in its atmospheric haze. These materials were first recorded during the Voyager 1 and 2 flybys of Titan and showed up as an optically thick pinkish orange haze layer. These materials are broadly classified into a chemical group whose laboratory analogs are termed "tholins", after the Greek word for "muddy". Their analogs are produced in the laboratory via the irradiation of gas mixtures and ice mixtures by radiation simulating Solar ultraviolet (UV) photons or keV charged particles simulating particles trapped in Saturn's magnetosphere. Fair analogs of Titan tholin are produced by bombarding a 9:1 mixture of N2:CH4 with charged particles and its match to observations of both the spectrum and scattering properties of the Titan haze is very good over a wide range of wavelengths. In this paper, we describe the historical background of laboratory research on this kind of organic matter and how our laboratory investigations of Titan tholin compare. We comment on the probable existence of polycyclic aromatic hydrocarbons in the Titan Haze and how biological and nonbiological racemic amino acids produced from the acid hydrolysis of Titan tholins make these complex organic compounds prime candidates in the evolution of terrestrial life and extraterrestrial life in our own Solar System and beyond. Finally, we also compare the spectrum and scattering properties of our resulting tholin mixtures with those observed on Centaur 5145 Pholus and the dark hemisphere of Saturn's satellite Iapetus in order to demonstrate the widespread distribution of similar organics throughout the Solar System.

Ammonia↗
PubMed2001

The physics, biology, and environmental ethics of making mars habitable.

The considerable evidence that Mars once had a wetter, more clement, environment motivates the search for past or present life on that planet. This evidence also suggests the possibility of restoring habitable conditions on Mars. While the total amounts of the key molecules--carbon dioxide, water, and nitrogen--needed for creating a biosphere on Mars are unknown, estimates suggest that there may be enough in the subsurface. Super greenhouse gases, in particular, perfluorocarbons, are currently the most effective and practical way to warm Mars and thicken its atmosphere so that liquid water is stable on the surface. This process could take approximately 100 years. If enough carbon dioxide is frozen in the South Polar Cap and absorbed in the regolith, the resulting thick and warm carbon dioxide atmosphere could support many types of microorganisms, plants, and invertebrates. If a planet-wide martian biosphere converted carbon dioxide into oxygen with an average efficiency equal to that for Earth's biosphere, it would take > 100,000 years to create Earth-like oxygen levels. Ethical issues associated with bringing life to Mars center on the possibility of indigenous martian life and the relative value of a planet with or without a global biosphere.

Antarctic Regions↗
PubMed2001

Geologic settings for aqueous organic synthesis on Titan revisited.

The photochemistry in Titan's cold reducing atmosphere is an evolutionary dead end. However, the hydrocarbons and nitriles deposited from the atmosphere can undergo aqueous synthesis into prebiotic molecules in ephemeral settings such as impact melt sheets. We re-examine the longevity of aqueous solutions on Titan, noting that recent measurements of the thermal conductivity of ammonia-rich ices suggest that the melt pockets may be longer-lived than previously thought. We propose an important role in surface organic reactions for ultraviolet sunlight transported to the surface as chemical energy stored in acetylene and released by polymerization at Titan's surface.

Carbon Monoxide↗
PubMed2000

Modern freshwater microbialite analogues for ancient dendritic reef structures.

Microbialites are organosedimentary structures that can be constructed by a variety of metabolically distinct taxa. Consequently, microbialite structures abound in the fossil record, although the exact nature of the biogeochemical processes that produced them is often unknown. One such class of ancient calcareous structures, Epiphyton and Girvanella, appear in great abundance during the Early Cambrian. Together with Archeocyathids, stromatolites and thrombolites, they formed major Cambrian reef belts. To a large extent, Middle to Late Cambrian reefs are similar to Precambrian reefs, with the exception that the latter, including terminal Proterozoic reefs, do not contain Epiphyton or Girvanella. Here we report the discovery in Pavilion Lake, British Columbia, Canada, of a distinctive assemblage of freshwater calcite microbialites, some of which display microstructures similar to the fabrics displayed by Epiphyton and Girvanella. The morphologies of the modern microbialites vary with depth, and dendritic microstructures of the deep water (> 30 m) mounds indicate that they may be modern analogues for the ancient calcareous structures. These microbialites thus provide an opportunity to study the biogeochemical interactions that produce fabrics similar to those of some enigmatic Early Cambrian reef structures.

Bacteria↗
PubMed2000

Thickness of tropical ice and photosynthesis on a snowball Earth.

On a completely ice-covered "snowball" Earth the thickness of ice in the tropical regions would be limited by the sunlight penetrating into the ice cover and by the latent heat flux generated by freezing at the ice bottom--the freezing rate would balance the sublimation rate from the top of the ice cover. Heat transfer models of the perennially ice-covered Antarctic dry valley lakes applied to the snowball Earth indicate that the tropical ice cover would have a thickness of 10 m or less with a corresponding transmissivity of > 0.1%. This light level is adequate for photosynthesis and could explain the survival of the eukaryotic algae.

Antarctic Regions↗
PubMed2000

The ultraviolet environment of Mars: biological implications past, present, and future.

A radiative transfer model is used to quantitatively investigate aspects of the martian ultraviolet radiation environment, past and present. Biological action spectra for DNA inactivation and chloroplast (photosystem) inhibition are used to estimate biologically effective irradiances for the martian surface under cloudless skies. Over time Mars has probably experienced an increasingly inhospitable photobiological environment, with present instantaneous DNA weighted irradiances 3.5-fold higher than they may have been on early Mars. This is in contrast to the surface of Earth, which experienced an ozone amelioration of the photobiological environment during the Proterozoic and now has DNA weighted irradiances almost three orders of magnitude lower than early Earth. Although the present-day martian UV flux is similar to that of early Earth and thus may not be a critical limitation to life in the evolutionary context, it is a constraint to an unadapted biota and will rapidly kill spacecraft-borne microbes not covered by a martian dust layer. Microbial strategies for protection against UV radiation are considered in the light of martian photobiological calculations, past and present. Data are also presented for the effects of hypothetical planetary atmospheric manipulations on the martian UV radiation environment with estimates of the biological consequences of such manipulations.

Atmosphere↗
PubMed2000

Metabolic activity of permafrost bacteria below the freezing point.

Metabolic activity was measured in the laboratory at temperatures between 5 and -20 degrees C on the basis of incorporation of (14)C-labeled acetate into lipids by samples of a natural population of bacteria from Siberian permafrost (permanently frozen soil). Incorporation followed a sigmoidal pattern similar to growth curves. At all temperatures, the log phase was followed, within 200 to 350 days, by a stationary phase, which was monitored until the 550th day of activity. The minimum doubling times ranged from 1 day (5 degrees C) to 20 days (-10 degrees C) to ca. 160 days (-20 degrees C). The curves reached the stationary phase at different levels, depending on the incubation temperature. We suggest that the stationary phase, which is generally considered to be reached when the availability of nutrients becomes limiting, was brought on under our conditions by the formation of diffusion barriers in the thin layers of unfrozen water known to be present in permafrost soils, the thickness of which depends on temperature.

Acetates↗
PubMed1999

Analytic investigation of climate stability on Titan: sensitivity to volatile inventory.

We develop a semiempirical grey radiative model to quantify Titan's surface temperature as a function of pressure and composition of a nitrogen-methane-hydrogen atmosphere, solar flux and atmospheric haze. We then use this model, together with non-ideal gas-liquid equilibrium theory to investigate the behavior of the coupled surface-atmosphere system on Titan. We find that a volatile-rich Titan is unstable with respect to a runaway greenhouse-small increases in solar luminosity from the present value can lead to massive increases in surface temperature. If methane has been photolyzed throughout Titan's history, then this runaway can only be avoided if the photolytic ethane is removed from the surface-atmosphere system.

Atmosphere↗
PubMed1999

Geomicrobiology of subglacial ice above Lake Vostok, Antarctica.

Data from ice 3590 meters below Vostok Station indicate that the ice was accreted from liquid water associated with Lake Vostok. Microbes were observed at concentrations ranging from 2.8 x 10(3) to 3.6 x 10(4) cells per milliliter; no biological incorporation of selected organic substrates or bicarbonate was detected. Bacterial 16S ribosomal DNA genes revealed low diversity in the gene population. The phylotypes were closely related to extant members of the alpha- and beta-Proteobacteria and the Actinomycetes. Extrapolation of the data from accretion ice to Lake Vostok implies that Lake Vostok may support a microbial population, despite more than 10(6) years of isolation from the atmosphere.

Antarctic Regions↗
PubMed1999

Thermal structure of Uranus' atmosphere.

Application of a radiative-convective equilibrium model to the thermal structure of Uranus' atmosphere evaluates the role of hazes in the planet's stratospheric energy budget and places a lower limit on the internal energy flux. The model is constrained by Voyager and post-Voyager observations of the vertical aerosol and radiative active gas profiles. Our baseline model generally reproduces the observed tropospheric and stratospheric temperature profile. However, as in past studies, the model stratosphere from about 10(-3) to 10(-1) bar is too cold. We find that the observed stratospheric hazes do not warm this region appreciably and that any postulated hazes capable of warming the stratosphere sufficiently are inconsistent with Voyager and ground-based constraints. We explore the roles played by the stratospheric methane abundance, the H2 pressure-induced opacity, photochemical hazes, and C2H2, and C2H6 in controlling the temperature structure in this region. Assuming a vertical methane abundance profile consistent with that found by the Voyager UVS occultation observations, the model upper stratosphere, from 10 to 100 microbar, is also too cold. Radiation in the 7.8-micrometers band from a small abundance of hot methane in the lower thermosphere absorbed in this region can warm the atmosphere and bring models into closer agreement with observations. Finally, we find that internal heat fluxes < or approximately 60 erg cm-2 sec-1 are inconsistent with the observed tropospheric temperature profile.

Acetylene↗
PubMed1999

Hypercalciuria and urolithiasis in a case of Costello syndrome.

Costello syndrome is characterized by postnatal growth deficiency, mental retardation, curly hair, coarse characteristic face, and loose skin of hands and feet. Patients with this syndrome have a high incidence of cardiac involvement, including arrhythmia, atrial septal defect, and hypertrophic cardiomyopathy. We report a 16-year-old adolescent female with Costello syndrome who presents with hypercalciuria and urolithiasis.

Abnormalities, Multiple↗
PubMed1999

Angiotensin converting enzyme inhibitor-induced angioedema: a report of two cases.

Angioedema is a rare but potentially fatal side effect of angiotensin converting enzyme (ACE) inhibitors. We report for the first time, two children with systemic lupus erythematosus who developed acute angioedema after the long-term use of enalapril. Prompt recognition and appropriate management of ACE-induced angioedema prevented life-threatening complications. This report highlights the potential risks of angioedema associated with the use of ACE inhibitors in children. Patients should be advised to seek medical treatment immediately if they experience swelling of the face, neck, or tongue, and especially if they have trouble breathing, speaking, or swallowing.

Adolescent↗
PubMed1999

Remote sensing for organics on Mars.

The detection of organics on Mars remains an important scientific objective. Advances in instrumentation and laboratory techniques provide new insight into the lower level detection limit of complex organics in closely packed media. Preliminary results demonstrate that algae present in a palagonite medium do exhibit a spectral reflectance feature in the visible range for dry mass weight ratios of algae to palagonite greater than 6%--which corresponds to 30 mg algae in a 470 mg (just optically thick (< 3 mm) layer) palagonite matrix. This signature most probably represents chlorophyll a, a light harvesting pigment with an emission peak at 678 nm.

Chlorophyll↗