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C P Adler

Publications and source records attributed to C P Adler.

At least 19 recordsLinked to original sources
PubMed1992

Prediction of recurrence in giant cell bone tumors by DNA cytometry.

The most interesting therapeutic aspect of giant cell bone tumors is which patients can be cured without a risk of recurrence by intralesional surgery (curettage). To find out the suitability of some DNA cytometric and morphometric parameters for showing differences between this group of patients (n = 9) and those with recurrence (n = 12), the parameters mean ploidy, 2cDI (mean square deviation of the tumor cell DNA content from the normal 2c value), mean nuclear area and its variability were calculated from cytologic specimens prepared by a cell separation technique from formalin-fixed, paraffin-embedded tissues, measuring the values of 100 stromal cells per case by a TV image analysis system. Further measurements were performed on 19 cases of different diseases of the bone and on an additional 17 cases of giant cell tumors without follow-up. The 2cDI allowed us to distinguish the two groups of patients, with and without recurrence, without overlap; even the lowest value for patients with recurrence was higher than the highest value for cured ones. Mean ploidy analysis resulted in a less convincing discrimination of the patients. Mean nuclear area and its variability failed to predict recurrence. Single-cell DNA cytometry provided a parameter, 2cDI, that was able to predict recurrence in patients with giant cell bone tumors with high sensitivity.

Adult↗
PubMed1991

Accuracy of vertebral mineral determination by dual-energy quantitative computed tomography.

Quantitative computed tomography is an established method for the non-invasive assessment of bone mineral content. Scanning with two different X-ray energies allows material-selective image reconstruction and separation on the basis of differing atomic numbers. As proven by chemophysical analysis of 45 bone samples, dual-energy quantitative computed tomography with basis material decomposition allows highly accurate measurement of bone mineral density with an error of 1.4%, independent of fat and soft tissue content.

Bone Density↗
PubMed1991

[MR tomography of aneurysmal bone cyst].

The preoperative findings of magnetic resonance imaging (MRI) in six histology-proven aneurysmal bone cysts (ABC) are examined and compared with previous publications concerning MRI of ABC. The signal intensities differ considerably, and not all of our cases conform with the literature data. They can be summarised in three different subheadings: one form that is very inhomogeneous in T1- and T2-weighting, with fluid-fluid levels in the cystic spaces; one intermediate form without fluid-fluid levels, which is inhomogeneous only in T2-weighted images; and finally, an unusual form of ABC that has homogeneous low signal both in T1- and T2-weighting, and which has not been described in literature so far.

Adolescent↗
PubMed1991

[Tuberculous arthritis--a rare, but important differential diagnosis in juvenile chronic arthritis].

We observed a 13 year old Turkish boy suffering from chronic arthritis of the left knee since 1983. Clinical symptoms as slow progression of the disease and laboratory data including a positive HLA B 27 test suggests the diagnosis of juvenile chronic arthritis. A tuberculous arthritis was initially excluded by X-ray examination of the chest. The positive tuberculin test was attributed to the BCG vaccination. Because of insufficient response to antiinflammatory drug therapy a synovectomy was performed for diagnostic as well as therapeutic reasons. Histopathological results suggested sarcoidosis. A second synovial biopsy of the affected joint revealed granulomas combined with multiple necrosis typical for tuberculous infection. The animal experiments showed positive results. Tuberculostatic therapy was successful with INH, myambutol and rifampicin. Joint function and MRI results markedly improved.

Adolescent↗
PubMed1990

Massive pelvic osteolysis in the Gorham-Stout syndrome.

Massive osteolysis is a very rare tumour-like lesion usually affecting young adults. There are 132 reported cases which we have reviewed, including 31 single cases of pelvic involvement. The term "massive osteolysis" is based on the typical radiological findings, such as increasing translucency and loss of bone density. The diagnosis of the Gorham-Stout syndrome must be confirmed by the microscopic finding of intramedullary vascular structures. Our patient was a 23 year old white Caucasian, who had the full clinical signs of Gorham-Stout syndrome. She had achieved 2 normal pregnancies and deliveries in spite of her massive pelvic osteolysis.

Adult↗
PubMed1990

Case report 587: Adamantinoma of the tibia mimicking osteofibrous dysplasia.

This case emphasized that the differential diagnosis of osteofibrous dysplasia and adamantinoma of the tibia can be difficult on roentgengrams as well as on histological studies. A radiological and histological diagnosis of osteofibrous dysplasia of the tibia in a young adult should always raise the consideration of the possibility of an adamantinoma, and in the correlation of the radiological features with the biopsy findings it is very important to gain representative tissue material for establishing the correct diagnosis of adamantinoma.

Adolescent↗
PubMed1989

Osteodensitometry of vertebral metastases after radiotherapy using quantitative computed tomography.

Bone density has been assessed during and after radiotherapy of metastases of the spine using quantitative computed tomography (QCT) in 19 patients with osteolytic vertebral lesions. All patients underwent external photon radiation with a total dose of 40 Gy over a period of 4 weeks. Measurements of vertebral mineral density were performed at the beginning, at the end, and 3 months after radiotherapy. In 13 patients with osteolytic metastases, radiotherapy achieved complete release of pain; it was unsuccessful in the remaining 6 patients. Immediately after successful radiotherapy, osteolytic metastases showed a decrease of bone density of 24.7% followed by an increase of 60.6% 3 months later. Normal bone surrounding the osteolysis showed an increase of density at the end and 3 months after radiotherapy. QCT has proved to be a helpful tool in assessing successful radiotherapy of metastases of the spine.

Absorptiometry, Photon↗
PubMed1989

[Pathologic bone fractures: definition and classification].

A bone fracture is a complete or incomplete discontinuity of bone caused by a direct or indirect force. A pathological bone fracture is a bone fracture which occurs without adequate trauma and is caused by a preexistent pathological bone lesion. Causes include resorption of bone mass (osteoporosis), reduction of bone quality (osteomalacia, osteonecrosis), insufficient bone production (osteogenesis imperfecta, fibrous dysplasia), augmented bone resorption (giant cell granulomas, aneurysmal bone cyst), pathological bone remodelling (Paget's disease), or local bone destruction due to tumorous growths. A pathological bone fracture has to be detected clinically as well as radiologically and its cause diagnosed histologically in order to ensure adequate therapy.

Bone and Bones↗
PubMed1985

Tumour-like lesions in the femur with cementum-like material. Does a "cementoma" of long bone exist?

Five hundred and seventy nine juvenile bone cysts were analysed to evaluate the radiological and histological structures. Most of the juvenile bone cysts showed a typical appearance radiographically; histologically they had a cyst wall consisting of fibrous tissue without an epithelial lining. In many of these lesions newly formed bone trabeculae, granulation tissue, calcium deposits, and in some cases focal deposits of a homogeneous material resembling cementum of tooth were observed. In 28 lesions a well circumscribed, round focus was observed within the proximal femur or femoral neck radiologically, showing dense calcification with a small central radiolucency. In some cases, the intraosseous focus was almost solid without a cystic appearance. Histologically the unusual bone lesions consisted almost exclusively of calcified cementum devoid of cells. Lesions of this type were found exclusively in the proximal femur of patients between 47 and 56 years of age. Because of the radiological and histological appearance we would like to call this solid lesion "cementoma of long bones". Operative therapy is not necessary.

Adolescent↗
PubMed1979

Case report 92.

Explore the source record for details and available documents.

Breast Neoplasms↗
PubMed1979

Differential diagnosis of cartilage tumors.

A total of 1187 cartilage tumors have been diagnosed at the Reference Center for Bone Tumors of the University of Freiburg; 67 of these were chondrosarcomas. All tumors were coded in terms of their frequency, age distribution, and localization. The typical radiographic, macroscopic, and histologic architecture is described for each tumor, and differential diagnostic aspects are described. Special attention is devoted to the distinction between proliferating chondromas and well-differentiated chondrosarcomas. which are often very difficult or even impossible to distinguish histologically. A grading system for chondrosarcomas is described. Cytophotometric DNA measurements may be applied to cartilage tumor cells in an effort to objectify the radiologic and histologic findings, and to make possible a decision between "benign" and "malignant". With the help of these modern histochemical methods it should be possible to solve differential diagnostic problems in cartilage tumors.

Cartilage Diseases↗
PubMed1979

[Primary and secondary perosteal reactions (author's transl)].

Radiological and histological comparative analysis of the morphological changes of periosteal reaction. A distinction is made between secondary periosteal reaction (so called periostitis ossificans or osseous periostosis), primary periosteal lesions (due to inflammation, trauma, fibrosis and neoplasia) and soft tissue lesions involving the adjacent periosteum. Secondary periosteal reactions are most frequent, indicating the need for search of its cause. Here biopsy of the periosteal reaction is often important for establishing an early diagnosis.

Bone and Bones↗