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C Osorio

Publications and source records attributed to C Osorio.

97 records · Page 6Linked to original sources
PubMedDate not supplied

Anapsos, an antipsoriatic drug which increases the proportion of suppressor cells in human peripheral blood.

Anapsos, an antipsoriatic drug, was administered to normal volunteers in order to study its possible activity on the immune system. After three days of treatment, the drug decreased the lymphoblastic response to PWM and very slightly reduced the serum levels of immunoglobulins. After five days of treatment, however, both values were normal. The response to ConA decreased, and there was an increase in the suppressor index and in the proportion of OKT 8+. The drug did not vary the proportion of OKT 4+ and OKT 3+ cells. These results suggest that anapsos acts by increasing the number of suppressor cells. Such anapsos-induced suppressor cells are probably responsible for the diminished response to ConA, but did not seem to significantly affect response to PWM and serum levels of Ig after five days of treatment.

Adolescent↗
PubMedDate not supplied

Analysis of immune response in oral tumors.

Currently, there is widespread disagreement over the role of the immune system in controlling, via the major histocompatibility complex, the organism's response to cells in the process of tumoral degeneration. One possible mechanism by which tumoral cells escape detection by the antitumoral surveillance system is the lack of expression of HLA class I molecules. The APAAP technique was used to study the levels of expression of these molecules and other cell markers on 27 oral cavity tumors. Heterogenous class I expression was recorded, some tumors completely lacking class I antigens. Similar patterns of expression were found for beta-2 microglobulin and ABC molecules (different class I chains encoded in different chromosomes). The number of DR/DP positive cells was similar to the number of immune cells infiltrating the tumors. Statistical analyses failed to show any significant relationship between class I antigen expression and the anatomoclinical parameters of tumoral aggressivity considered.

Antigens, Neoplasm↗