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Biomedical subjects

C Opitz

Publications and source records attributed to C Opitz.

At least 55 records · Page 3Linked to original sources
PubMed1989

[Three-dimensional recording of changes in infant jaws with bilateral lip-maxilla-palate clefts with special reference to the results of preoperative orthodontic therapy].

Bilateral clefts are more difficult to treat than unilateral ones. The most important step during the orthopedic therapy is the retrusion of the premaxilla between the lateral segments of the maxilla. Thus the anterior cleft width, as opposed to the medial and posterior cleft width, did not become smaller. The position of premaxilla is mainly shown in the sagittal measurement values. The values of slope also changed in this sample. The maxilla became more flat. The preoperative orthodontic therapy can also be seen as advantageous in the case of bilateral clefts.

Child, Preschool↗
PubMed1989

[Frequency and prevalence of anomalies in shape, number and structure in locally limited disorders of the odontogenesis].

Anomalies in shape, number and structure of deciduous and permanent teeth in patients with different kinds of clefts are a sign of a disturbed developmental process. Their localisation, typically in the immediate vicinity of the cleft formation, and their exclusive presence at the upper medium and lateral incisors led to the presumption of a direct correlation with the genesis of the cleft formation. An early preventive individual care and the consequent complex stomatological therapy are a prerequisite for the realization of the morphological, functional and aesthetic conditions that effectively assist in the social accommodation of patients with different kinds of clefts.

Cleft Lip↗
PubMed1987

[A new concept of normal and pathologic development of the primary palate. 2. The formal genesis of the open and covered cleft lip and jaw].

In part 1 of this work we have shown that in each mammalian embryo the nasal fin represents a masked physiological cleft lip and jaw. In this double-layered "Epithelmauer" the process of epithelium separation along the differentiation-line may undergo various fates: 1. It can completely fail to take place (resulting in total cleft lip and jaw) or can be interrupted (resulting in incomplete cleft). 2. The persisting oral epithelium of the nasal fin may be loosened and moved away with a little temporal retardation. Thereby the potential osteoblasts and myoblasts cannot meet and join at right time and they retract away from the midline epithelial seam. The minimal and subcutaneous cleft lip and the submucous clefts of the jaw and the mesenchymal bridges may result. 3. Only in very rare cases the cleft lip and jaw develop in another way, namely if the underdeveloped facial processes do not meet.

Animals↗
PubMed1987

[A new concept of the normal and pathological development of the primary palate. 1. The normal fate of Hochstetter's epithelial wall].

The following conclusions as to the normal development of the primary palate were drawn from literary and own embryological studies and from morphological evaluations of congenital malformations in this region: 1. The nasal fin or so-called "Epithelmauer" consists of two epithelial layers. It is build, if the epithelial surfaces from the medial and lateral nasal processes touch each other. It represents a masked form of the oro-nasal groove which is also to be found in embryos of sauropsids. Therefore all mammalian embryos have a physiological cleft lip and jaw, which must be removed in order to create a mesenchymal fusion. 2. In its upper part the nasal fin consists of respiratory epithelium (nasal connecting lamina) and in its lower part it consists of oral epithelium (oral connecting lamina). 3. Many findings in the normal embryo and the results of pathological development argue that the cells of the nasal fin are not destroyed by mesenchyme but they persist. 4. Along the differentiation-line the oral epithelium separates gradually from the respiratory epithelium (remaining on the spot). 5. The oral epithelium is moved towards the palate thus permitting the mesenchymal fusion between the adjacent processes of the face. 6. This shifting oral connecting lamina is integrated into the epithelium of the palate.

Animals↗
PubMed1979

[Genetic counseling of parents with children with clefts].

The elucidation of the aetiology of the individual case has proved to be of fundamental importance to the counselling interview as well as to the assessment of the risk for further affected children. Up to now, a genetic cause in the form of chromosomal or gene mutations can be assumed only if the cleft is related to a distinct syndrome. An isolated cleft obviously owes its origin to a combination of genetic and extrinsic factors. Consequently, the assessment of the risk of repetition is to a great extent based on empirical values.

Adult↗
PubMed1978

[Orthodontic treatment in cases of mandibulo-facial dysostosis].

The author describes the clinical picture of mandibulofacial dysostosis and gives reasons for the necessity for early orthodontic treatment. Two examples are presented. The analysis of the case histories of a total of 10 patients with this syndrome showed that the responsiveness to functional orthodontic appliances is greatest in children with bilateral mandibulofacial dysostosis. The need for co-operation with other disciplines involved is pointed to.

Child↗
PubMed1978

[Fluorescence-analytical studies of the reaction of several psychoactive drugs with membrane structures of the CNS].

The use of 1-anilino-8-naphthalene sulfonate (ANS) as an indicator of membrane conformational perturbations induced by psychoactive drugs was tested with regard to its specificity considering both chemical structure (phenothiazine, butyrophenone, phenylalkylhydrazine) and pharmacological activity (major transquilizers, antidepressants, antihistamines), on the one hand, and brain region (cortex, striatum, hippocampus) and subcellular structure of membranes (mitochondria, microsomes, synaptosomes), on the other. Not only a weak strengthening of ANS affinity to membrane constituents by chlorpromazine and promethazine (haloperidol and phenelzine were without effect), but also the alteration of membrane structure in such a way as to create additional ANS binding sites by chlorpromazine and to a smaller degree also by promethazine and haloperidol (phenelzine was without effect) resulting in a manifold increase in fluorescence indicated any relation to functional characteristics of biological material or properties of drugs. Apparent dissociation constants and membrane ANS binding sizes are reported.

Anilino Naphthalenesulfonates↗
PubMed1977

[Surgical closure of cleft palate and its immediate effect on the maxillary development].

During the service life of the primary dentition, the direct effects of surgical closure of the palate on the size of the maxilla are unimportant for all types of clefts. Narrowings of more than 1 mm occurred only in the posterior region of the dental arch. Narrowings in the anterior region of the dental arch were observed to a small extent in patients with unilateral and bilateral clefts. There was no difference in the changes of the upper dental arch between one-stage and two-stage closures of the palate.

Child↗