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Biomedical subjects

C Ollivier

Publications and source records attributed to C Ollivier.

11 recordsLinked to original sources

A novel approach for the formation of carbon-nitrogen bonds: azidation of alkyl radicals with sulfonyl azides.

Two preparatively attractive methods for the azidation of alkyl radicals are described. Secondary and tertiary alkyl iodides and dithiocarbonates are easily converted into the corresponding azides, either by reaction with ethanesulfonyl azide in the presence of dilauroyl peroxide, or by treatment with benzenesulfonyl azide and hexabutylditin in the presence of a radical initiator. Interestingly, intramolecular tandem radical cyclization-azidation processes can be performed in high yields.

Journal Article↗

[Requirements for the successful implementation of unity of care: study of a computer-assisted dispensation of pharmaceuticals].

PURPOSE: Even though computerized workstations bring undisputed benefits in nursing units, introducing them is still hard when most of the staff members have to share the workstation. We took advantage of the implementation of the drug prescription software SAUPHIX in a nephrology department to better define the encountered difficulties. The workstation described in this paper is shared by physicians who enter their prescriptions (proprietary names, doses, routes of administration), nurses who use dosage schedules for drug administration, and the chemist who has authority to control prescription orders. METHODS: Six months after the implementation of the workstation, physicians and nurses had to fill out an anonymous questionnaire aimed at assessing each function of the software. RESULTS: Prescriptions proved to be more accurate and legible, while management of drugs was more precise. However, interns complained that entering data was time consuming. Furthermore, they raised objections to control of prescription orders. Nurses criticized dosage schedules, the primary reason being that they had to change their practice. The convenience of notebooks was questioned by both physicians and nurses who would have preferred a greater number of desktop computers at their disposition. CONCLUSION: The implementation of a computerized workstation requires information, diplomacy and negotiations to obtain real implication of the staff. Tasks and schedules must be specified for everybody. The system has to be carefully customized, according to the requirement of the unit. Computers must be properly chosen and allocated in sufficient number. Finally, appropriate preparation, staff training and follow-up of the computerized system are essential.

Drug Prescriptions↗

[Prevalence of arterial hypertension in the Brittany population].

The epidemiology of arterial hypertension was studied from 1988 to 1991 in a region in the west of France comprising 500,000 inhabitants. Prevalence of arterial hypertension was calculated to 16.2%, significantly higher in men than in women (22.5% vs 11.2%).

Adolescent↗

[Efficacy of spiramycin and tylosin in preventing mycoplasmosis in chicks experimentally infected with mycoplasma gallisepticum].

In order to evaluate the activity of two drugs (spiramycin and tylosin), one-day-old chicks are inoculated with a virulent strain of Mycoplasma gallisepticum (MG) and given spiramycin (3 different doses) or tylosin (1 dose) for two or three days. Effectiveness is assessed on different criteria: mortality, symptoms, weight gains, gross lesions, MG tracheal recovery and serology. Results show that spiramycin and tylosin have the potential of reducing mortality, symptoms and lesions. Weight gains of treated birds are greater than those of infected untreated birds. However, MG was recovered from tracheas of all treated birds.

Ammonium Chloride↗