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Biomedical subjects

C Ohkubo

Publications and source records attributed to C Ohkubo.

41 records · Page 3Linked to original sources
PubMedDate not supplied

Anti-pressor effect of a Chinese-Japanese herbal medicine, saiko-ka-ryukotsu-borei-to on hemodynamics in rabbits.

Saiko-ka-ryukotsu-borei-to (TJ-12) is a traditional Chinese-Japanese medicinal mixture clinically used for the treatment of hypertension and/or atherosclerosis concurrent with neurotic disorders. Study on the effect of TJ-12 on the vasoconstriction of cutaneous arterioles induced by nor-adrenaline (NA) was carried out using a rabbit ear chamber (REC) under conscious conditions. Before and after oral administration of TJ-12 everyday for 2 weeks, the same position of an arteriole within a REC was analyzed using an image shearing monitor every minute up to 15 min after varying doses (0.3, 1.0, 3.0 and 10.0 micrograms/kg i.v.) of NA. The changes of mean arteriolar diameter and vasomotion amplitude, before and after feeding of TJ-12 (1% w/w) supplemented diet were compared in the same position. Consequently, the pretreatment with TJ-12 significantly attenuated the changes of mean diameter of NA-induced vasoconstriction and also shortened its duration. In addition, concurrent with its cutaneous microcirculatory response, the pretreatment with TJ-12 systemically suppressed the increase of blood pressure under NA-induced vasoconstriction. These results suggest that the anti-pressor effect of TJ-12 might be apparently attributable to the inhibition of NA-induced vasoconstriction.

Animals↗
PubMedDate not supplied

Acute effects of static magnetic fields on cutaneous microcirculation in rabbits.

The acute microcirculatory effects of locally applied of static magnetic (SMF) to the cutaneous tissue within a rabbit ear chamber (REC) were evaluated during consciousness. Rabbits with REC were subjected to microphotoelectric plethysmography. Power levels of SMF upon the REC were controlled at 1, 5, 10 mT(milli Tesla), respectively. The duration of exposure was 10 minutes. The exposure of SMF induced variation of vasomotion with a latency of about 10 seconds in a non-dose dependent manner. SMF had a biphasic effect upon the microcirculatory system; when the vascular tone was low, the SMF enhanced vasomotion, and when it was high, the SMF suppressed vasomotion. The results suggest that the SMF can modulate vascular tone due to vasomotion which may involve in clinical efficacy for refraining from neck and shoulder stiffness.

Animals↗
PubMedDate not supplied

Subchronic effects of static magnetic fields on cutaneous microcirculation in rabbits.

The subchronic effects of locally applied of static magnetic fields (SMF) on the cutaneous microcirculation within the rabbit ear chamber (REC) were evaluated under conscious conditions. The microcirculatory vasomotion within a REC was measured continuously and analyzed multilaterally by microphotoelectric plethysmography and an image shearing monitor. A SMF, a 180 mT (milli Tesla) cylindlical samarium-cobalt permanent magnet was attached on REC for 24 hours to 4 weeks Exposure to SMF for 1-3 weeks significantly induced long-lasting vasodilation with enhanced vasomotion as compared to control group. Thereafter the active vasomotion of SMF group was depressed and/or returned to initial values and there was no difference between SMF and control groups. The results suggest that the subchronic exposure of SMF can bidirectionally modulate microcirculatory vasomotion in cutaneous tissue.

Animals↗