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Biomedical subjects

C Ogawa

Publications and source records attributed to C Ogawa.

28 records · Page 2Linked to original sources

Focal obliteration of the descending aortic interface on normal frontal chest radiographs: correlation with CT findings.

PURPOSE: To assess the frequency, location, correlation with age, and cause of partial obliteration of the descending aortic interface on normal frontal chest radiographs. MATERIALS AND METHODS: Concurrent chest radiographs and computed tomographic (CT) scans of 1,500 patients in whom CT findings excluded a diagnosis of paraaortic pathologic processes were reviewed retrospectively. RESULTS: Aortic interface obliteration was identified on 134 images (8.9%), which included 43 (2.9%) in the suprahilar and upper hilar portion, 56 (3.7%) in the lower hilar portion, and 46 (3.1%) in the cardiac portion of the interface. The causes were direct contact with or proximity to the aortic margin by pulmonary arteries at the suprahilar and upper hilar portion, superior segment vessels at the lower hilar portion, and various structures, including left inferior pulmonary vein, mediastinal fat, and left ventricle at the cardiac portion. CONCLUSION: Partial aortic interface obliteration can be seen on normal frontal chest radiographs because of obstruction by small adjacent structures.

Adolescent↗

Pasteurella ureae endocarditis.

Pasteurella ureae is found in the normal human respiratory flora. We encountered a case of endocarditis caused by Pasteurella ureae. The patient was a 59-year-old man with a history of Staphylococcus aureus endocarditis. After treatment with antibiotics, blood cultures became negative, and the patient recovered completely. The incidence of endocarditis due to this organism is very rare; this case is the second clinically diagnosed case report.

Anti-Bacterial Agents↗

CT visualization of the major pulmonary fissures: value of 25 degrees cranially tilted axial scans.

OBJECTIVE: CT visualization of the major (oblique) pulmonary fissures is often hampered by partial volume effects of adjacent lung parenchyma. We attempted to improve visualization of the fissures by using 25 degrees cranially tilted axial scans. An initial in vitro study also was performed. MATERIALS AND METHODS: Both conventional and 25 degrees tilted axial CT scans were obtained in 40 adult patients. After scans with 2-mm collimation were obtained at 1 cm and 6 cm below the carina, the gantry was tilted 25 degrees cranially to be perpendicular to the plane of the major fissures, and scans with 2-, 5-, and 10-mm collimation were obtained at the same two levels. The appearance of the fissures was classified as linear opacity, band-like opacity, or avascular area for each lung at each level. RESULTS: On 2-mm conventional axial scans, the major fissures were seen as linear opacities in three to 23 patients (8-58%), as band-like opacities in 13-31 (32-78%), and as avascular areas in one to seven (2-18%). (Ranges indicate lowest and highest values when data for the two levels in the two lungs are grouped separately.) On 2-mm tilted scans, the ranges were 32-38 patients (80-95%), one to eight (2-20%), and zero to one (0-2%), respectively. The 2-mm tilted scans were significantly superior to the 2-mm conventional axial scans for showing the fissures (p < .01). Direct visualization as linear or band-like opacities was possible even on 10-mm tilted scans in 15-32 cases (38-80%). CONCLUSION: Our results show that visualization of the major fissure is improved when tilted CT scans rather than conventional axial scans are used.

Adult↗

Hormonal control of collagenase inhibitor production in rabbit uterine cervical fibroblast-like cells.

Rabbit uterine cervical fibroblast-like cells maintained in fetal calf serum-free medium were found to biosynthesize and secrete a collagenase inhibitor into the culture medium. All the properties of this inhibitor were similar to those that have been described so far for the tissue inhibitor of metalloproteinases. Both progesterone and 17 beta-estradiol significantly increased the level of collagenase inhibitor without the proliferation of cells. These data suggest that both progesterone and estradiol regulate collagenolysis in the uterus bifunctionally by acceleration of the inhibitor production in addition to their known inhibitory actions towards collagenase biosynthesis.

Animals↗

Suicidal insulin overdose in a type 1 diabetic patient: relation of serum insulin concentrations to the duration of hypoglycemia.

We present a case of a 31-year-old Type 1 diabetic woman who self-administered 2400 units of insulin mixture (70% NPH human insulin and 30% Regular human insulin) as a suicidal attempt. The subsequent hypoglycemia was prolonged probably due to delayed absorption of the subcutaneous insulin, but it was not very difficult to control despite the administration of large amounts of insulin. Although the estimated serum insulin level was not well correlated with the severity of hypoglycemia, the hypoglycemia subsided when the serum insulin level returned to the physiological level. Therefore, the study of insulin pharmacokinetics after insulin overdose may be useful to know the necessary duration of exogenous glucose administration required to manage the medical emergency of severe insulin intoxication in future cases.

Adult↗