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Biomedical subjects

C O'Callaghan

Publications and source records attributed to C O'Callaghan.

97 records · Page 6Linked to original sources
PubMed1984

C reactive protein concentrations in neonates: determination by a latex enhanced immunoassay.

A latex enhanced immunoassay on a centrifugal fast analyser was used to compare serum C reactive protein concentrations in maternal and neonatal blood. In the neonate the C reactive protein concentration at birth was less than 1.0 mg/l; the concentration rose slightly during the first two weeks of life. There was no correlation between C reactive protein concentrations in maternal and neonatal sera. No significant difference was found between the C reactive protein concentrations in blood obtained by either heel prick or venepuncture.

Blood Specimen Collection↗
PubMed1976

Cefuroxime, a new cephalosporin antibiotic: activity in vivo.

The pharmacokinetic properties of cefuroxime have been evaluated in laboratory animals. On injection into mice, rats, and rabbits by the subcutaneous or intramuscular routes, high serum level peaks were recorded. There was no significant absorption after oral administration. After injection, the antibiotic was excreted in large amounts in the urine. It was well distributed in the body and penetrated into the tissues at a satisfactory rate. This, coupled with a low degree of serum protein binding, was correlated with a very good protective effect in animals (mice, rats, and rabbits) experimentally infected with a wide range of bacteria, including beta-lactamase-producing strains. It is concluded that cefuroxime should have a good potential for treating a wide range of bacterial infections in humans.

Animals↗
PubMed1972

Inhibition of beta-lactamases by beta-lactam antibiotics.

The inhibitory properties of a selected number of beta-lactam antibiotics were studied, with the use of three distinct types of beta-lactamases. The three enzymes were found to be distinguishable on the basis of their susceptibility to inhibition. Not one of the potential inhibitors tested was found to be a potent inhibitor of all three enzymes, but nafcillin possessed the broadest inhibitory activity. The enzyme isolated from Enterobacter cloacae was found to be the most susceptible. In some cases, the degree of inhibition varied with the time of incubation, and, depending upon the time chosen, widely different observations could be made. It is suggested that, in studies such as these, every consideration should be given to the period of incubation and to the concentration of inhibitor employed. Mixtures of inhibitor and cephaloridine did not always act synergistically against growing bacteria, and a number of reasons for failure are suggested.

Anti-Bacterial Agents↗
PubMedDate not supplied

Paradoxical deterioration in lung function after nebulised salbutamol in wheezy infants.

In 13 infants with a history of wheezing, airways resistance and specific conductance worsened after administration of nebulised salbutamol (0.5 ml sabutamol respirator solution in 1.5 ml normal saline). This paradoxical bronchoconstriction was greatest at 5 min and lasted for up to 15 min. The nebulised solution was found to be acidic and hypo-osmolar, both of which properties have been linked to bronchoconstriction in asthmatic subjects, but even with an initially iso-osmolar solution osmolality increased with time of nebulisation because of evaporation.

Aerosols↗
PubMedDate not supplied

Signs of the times.

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Humans↗