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Biomedical subjects

C Nozzoli

Publications and source records attributed to C Nozzoli.

11 recordsLinked to original sources

Vasovagal reactions induced by head-up tilt and tests of vagal cardiac function.

The vagal cardiac activity was compared in two groups of patients with a history of syncope. Sixty-one patients (Group A) experienced vasovagal reactions induced by head-up tilt, 61 sex and age-matched patients (Group B) did not. No significant differences in vagal cardiac activity between two groups were found. Group A was further subdivided into two subgroups: A1 (14 patients) with stronger, and A2 (47 patients) with smaller cardioinhibition. Again, vagal cardiac activity was not different between two subgroups. Thus, the baseline vagal cardiac activity ('tone') seemed not to be helpful in predicting the susceptibility to vasovagal orthostatic syncope and in discriminating the patients with stronger cardioinhibition.

Adult

The Valsalva maneuver in vasodepressor syncope.

In this work the authors propose the Valsalva maneuver as a diagnostic test in a group of patients shown, by anamnestic, physical, and instrumental criteria, to be affected by vasodepressor syncope. They studied the response of heart rate and baseline arterial pressure to the maneuver performed in passive orthostasis in 7 healthy volunteers and 24 patients. These patients showed a hypotensive response and a time of recovery to the initial values that was significantly longer than in the control group (p less than 0.01). The authors conclude that studying the response to the Valsalva maneuver can be useful in the diagnosis of vasodepressor syncope.

Adolescent

Micturition syncopes.

Micturition syncope accounts for 8.39% of the total number of syncopes and is prevalent among men in the 50 and 60 year age groups. The cardiovascular vegetative nervous system is unaffected in patients with micturition syncope. Sixty-one percent of patients with micturition syncope also exhibit other kinds of syncope. These patients experience vasovagal reaction during the vegetative activation tests more often than patients exclusively with micturition syncope.

Adolescent

Syncopes with reference to sex and age.

The incidence of different types of syncopes and their relationship to sex and age were studied. In agreement with previous findings in the literature, a cause of syncopes in a large proportion of patients could not be determined. Vasovagal syncopes clearly prevailed among diagnosed syncopes with a female prevalence. Other syncopes (due to orthostatic hypotension, carotid-sinus syndrome etc.) had a male preponderance. Syncopes with poor prognosis prevailed in elderly patients.

Adolescent

Sympathetic activation and muscle spindle.

An adrenergic central control on fusimotor activity has been demonstrated since 1954. At peripheral level, a muscle spindle autonomic innervation is not clearly demonstrated in man, but several data seem to suggest a direct autonomic innervation of muscle spindle in cats and rabbits. Data obtained in patients with peripheral adrenergic denervation (Idiopathic Orthostatic Hypotension) suggest a prevalent control of central adrenergic pathways on muscle spindle sensitivity.

Blood Pressure

Head-up tilt for triggering and diagnosing syncope.

Head-up tilt to 70 degrees lasting for 30 min is a further useful test for studying syncope. In 26.69% of 109 consecutive out-patients referred for loss of consciousness, it induced vasodepressor and/or cardioinhibitory reactions. All symptomatic patients had similar EEG changes and blood pressure fall during symptoms: by contrast, ECG features, due to vagal activation, were different. The pathogenetic mechanism of vasovagal or vasodepressor syncope is an abrupt sympathetic cardiovascular inhibition with more or less marked vagal cardiac activation. This cardiovascular pattern is due to a cardiac reflex in orthostatic syncope or, probably, to a central activation in emotional fainting.

Adolescent