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Biomedical subjects

C Norman

Publications and source records attributed to C Norman.

At least 127 records · Page 7Linked to original sources
PubMed1983

Droperidol-fentanyl as an aid to blood collection in rabbits.

Administration of a droperidol-fentanyl combination to laboratory rabbits at a dose of 2.5 mg/kg and 0.05 mg/kg body weight, respectively, produced vasodilatation which greatly facilitated blood withdrawal from the central auricular artery. The method eliminated the need for vacuum devices or topical irritants and posed little risk or discomfort to the animal.

Animals↗
PubMed1982

Reactivity of cold agglutinins with subsets of human lymphocytes of various origins.

Forty-five cold agglutinins (CA) were tested against various populations of lymphocytes by cytotoxicity and immunofluorescence assays. Marked differences were observed between anti-I and anti-i CA. Thirty-six per cent of anti-I killed preferentially peripheral blood and tonsillary B lymphocytes, whereas only 12 per cent killed preferentially T lymphocytes. Anti-I killed a much higher proportion of B-chronic lymphocytic leukemia cells than peripheral blood lymphocytes, peripheral blood B cells or T-chronic lymphocytic leukemia cells. Forty-three per cent of anti-i killed preferentially peripheral blood T lymphocytes and 54 per cent killed preferentially tonsillary T cells, whereas only 14 per cent killed more peripheral blood B cells and none killed preferentially tonsillary B cells. The kill of thymic lymphocytes and T-chronic lymphocytic leukemia cells by anti-i was very high, whereas the kill of B-chronic lymphocytic leukemia cells was very low. Almost all CA of other than I-i specificities showed preferential kill of peripheral blood B (83 per cent) and tonsillary B (67 per cent) cells. Tonsillary lymphocytes were usually more susceptible to the cytotoxic activity of CA than peripheral blood lymphocytes. Cold agglutinins with kappa light chains killed more B cells whereas CA with gamma light chains seemed to kill more T cells. Cytotoxicity did not correlate to the utilization of complement. It is suggested that the density and/or the accessibility of membranous antigens may be different on B and T cells, or alternatively that in addition to antigens common to all lymphocytes, anti-I and non-I/i cold agglutinins recognize specific antigenic determinants on B lymphocytes, whereas anti-i cold agglutinins recognize specific antigenic determinants on T lymphocytes.

Agglutinins↗
PubMed1977

USA.

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Nuclear Energy↗