[Evaluation of the distensibility of the arterial system by the study of the ratio I-A of the carotidogram (experimental and clinical correlations)].
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Adolescent↗
Biomedical subjects
C Nogues
Publications and source records attributed to C Nogues.
[Physiologic and physiopathologic effects of transverse accelerations in aerospace medicine].
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Acceleration↗
French research program on the physiological problems caused by weightlessness. Use of the primate model.
The need to acquire a better knowledge of the main biological problems induced by microgravity implies--in addition to human experimentation--the use of animal models, and primates seem to be particularly well adapted to this type of research. The major areas of investigation to be considered are the phospho-calcium metabolism and the metabolism of supporting tissues, the hydroelectrolytic metabolism, the cardiovascular function, awakeness, sleep-awakeness cycles, the physiology of equilibrium and the pathophysiology of space sickness. Considering this program, the Centre d'Etudes et de Recherches de Medecine Aerospatiale, under the sponsorship of the Centre National d'Etudes Spatiales, developed both a program of research on restrained primates for the French-U.S. space cooperation (Spacelab program) and for the French-Soviet space cooperation (Bio-cosmos program), and simulation of the effects of microgravity by head-down bedrest. Its major characteristics are discussed in the study.
Adaptation, Physiological↗
Time elapsing from cancer diagnosis and anxiety in women attending cancer genetic clinics.
The aim of this study was to investigate the effects of cancer genetic consultations on feelings of anxiety in women with breast/ovarian cancer. Among the 138 women attending six French clinics during a one-year period, 115 (83.3%) answered pre- and post-consultation questionnaires. The state anxiety score (Spielberger's STAI) was lower (paired t-test, p<0.001) after the consultation (34.7 9.4) than before (38.8 10.5). The time elapsing since cancer diagnosis (r=-0.28, p=0.007) was the main predictor of the decrease in anxiety. The patients consulting earlier after their cancer was diagnosed were more anxious before the consultation than those consulting later: whereas their anxiety states after the consultation were similar. The consultation effectively decreased the anxiety observed and the anxiety felt by cancer patients before the consultation may constitute an anticipatory stress response that should be investigated.
Anxiety↗
[The state of bone tissue in monkeys in experiments in the Cosmos-1887 biosatellite].
Using invasive and noninvasive techniques, we studied bone changes in primates flown for 13 days on Cosmos-1887 and compared them with the data obtained from vivarium control animals and from the flown primates that were after flight exposed to a ground-based synchronous experiment in the biosatellite mockup. It was found that bone density in the diaphysis of the tibia decreased while its growth rate remained unchanged or diminished. Contact X-raying indicated a higher rate of endosteal resorption in the flown primates when compared with the controls. Histomorphometric measurements of iliac bioptates displayed signs of inhibited bone formation after flight. The above observations are discussed and compared with the results obtained in previous biosatellite flights and ground-based studies.
Animals↗
[The induced hyperlipemia test. 10 years of experience].
The induced hyperlipemia test, which is easly to administer, yields very interesting information for the study of lipidic metabolism in arteriosclerosis patients. Its use, in both the pre- and post-operative phases, has brought out the valuable effect of ligature of the intestinal lymphatics in treating arteritis. It may also enable us to determine whether there is a hereditary factor or family predisposition to arteriosclerosis. Furthermore, the test makes it possible to confirm diagnosis of obstruction of the lymphatics of the gut in exsudative enteropathy and in various dysfunctious of the chyliferous vessels (sclerosis, rupture, tumoral invasion) without to resort to the use of radioactive substances.
Adult↗
[Abrikosov's tumor in the newborn].
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Ameloblastoma↗
[Diagnosis of chyliferous blockage by the hyperlipidemia test (author's transl)].
In our hyperlipidemia test, the total lipids curve, a plateau without a postprandial peak, allows an easy diagnosis of the chyliferous blockage. The malformation of chyliferous vessels produces the congenital forms: exsudative enteropathy, chyloperitoneum, spontaneous chylothorax, chylous cyst of the mediastinum, reflux of chyle in the pulmonary lymphatics, lymphoedema with chyle reflux in the lymphatics of the leg and chyluria. The acquired forms comprise the post-infectious sclerosis of the intestinal lymphatics and the neoplastic invasions of the mesenteric lymph nodes. The optical density curve brings some informations for a better understanding of lipid's absorption.
Adult↗
[Globoid cells leukodystrophy apropos of a case of Krabbe's disease].
A case of Krabbe's leucodystrophy is reported after photon and delayed ultrastructural microscopic study. Cerebroside overload within the cerebral globoid cells was shown as well as in the interstitial histiocytic infiltration of the peripheral nerves. Reviewed with the published literature, the characteristics of the inclusions observed seem to be unspecific and, from a morphological standpoint, Krabbe's disease may be related to the gangliosidoses.
Brain Diseases↗