Search PubMed⌕ Search

Biomedical subjects

C Nezelof

Publications and source records attributed to C Nezelof.

At least 127 records · Page 7Linked to original sources
PubMed1981

[Cell populations of the human mandibular condyles during growth and in the adult (author's transl)].

Tumours of cartilaginous origin dominate the group of tumours of the mandibular condyles. These cartilaginous tumours consist in fact of hyperplasia of the growth zone or osteochondroma in the young adult or reawakening of the latter in the older adult in whom an occlusion problem originally is not without aetiological interest. Osteomas of the condyles are stabilised and ossified forms of such hypercondylism. Other tumours may be seen and are related to the original cell. Malignant tumours are rare.

Adolescent↗
PubMed1981

[Acetylcholinesterase activity in suction rectal biopsies. An appraisal of its value in the diagnosis of Hirschsprung's disease (author's transl)].

Demonstration of an increase in Acetylcholinesterase activity within the terminal nerves of the aganglionic segment in Hirschsprung's disease can provide a useful additional criterion to the diagnosis of this disease. The value as well as the limitations of this histochemical investigation, when performed on superficial suction biopsies, is evaluated. 135 rectal biopsies taken from 123 children were studied. In 28 biopsies performed on children with Hirschsprung's disease, the correct diagnosis was established in 19 cases suggested in 5 and missed in 2. Conversely in 107 control specimens, the results of the histochemical method were correctly negative on 97 occasions and falsely positive on 2.

Acetylcholinesterase↗
PubMed1980

Diagnosis of pneumocystis carinii pneumonia using an endobronchial brushing technique. A report on twenty-one cases in immunocompromised children.

By examining the endobronchial brushings from 65 infants and children with interstitial pneumonia--characterized by a severe hypoxia and diffuse lung infiltrates--we have detected the cysts of pneumocystis carinii in 17 of 21 subsequently confirmed cases. The rapid diagnosis and subsequent specific treatment have allowed the recovery of 18 of these children. The particular significance of this article is the youth of the patients, whose ages ranged from 4 months to 15 years.

Adolescent↗
PubMed1980

Histiocyte X positivity for nonspecific esterase.

The cell membrane and X bodies of histiocytes X from two cases of eosinophilic granuloma were stained by nonspecific esterase. The results show that histiocytes X possess a cell membrane exoenzyme similar to that of other histiocytes, such as alveolar macrophages, but the role of the X body as related to enzyme activity remains an unknown.

Cell Membrane↗
PubMed1980

[Non-ossifying fibroma in children: a surgical condition?].

From 21 non osteogenic fibromas submited to surgery, authors bring their surgical experience of that tumor. This frequent benign tumor of the bone in childwood has generally a good pronostic; it evolves to spontaneous recovery in most of the cases. It is often latent, asymptomatic, and of an accidental diagnosis. The roentgenographic exam allows most often an accurate diagnosis. Sometimes it remains doubtful, and a biopsy is then necessary. The histologic exam will easily confirm the nature of the lesion. In half of the cases, non ossifying fibroma is revealed by a spontaneous fracture. It seems illusive to hope a complete filling of the tumor cavity with an orthopaedic treatment alone; it must be done a resection of the tumor together with a bone graft and an osteosynthesis. In the end, in some cases of a fortuitous diagnosis, the bone is made so weak that a resection with bone graft is necessary. And so, during the evolution of non osteogenic fibroma, there is a certain place for surgical treatment.

Adolescent↗
PubMed1979

Collagenolytic activity of eosinophilic granuloma in vitro.

Lytic activity of eosinophilic granuloma and other tumours was studied in vitro on collagen substrate. Collagen degradation was measured through the release of hydroxyproline-rich peptides into the medium. The in vitro lytic action was at a maximum in the case of EG and was correlated with the presence of histiocytic cells.

Bone Neoplasms↗
PubMed1979

Disseminated histiocytosis X: analysis of prognostic factors based on a retrospective study of 50 cases.

This work is a retrospective study of 50 cases of DHX, collected over a period of 27 years. 24 children died, 26 are still alive. The prognosis for DHX was neither dependent on age (usually occurring in children under 2 years) nor on histological findings but on the extent of the lesions. It was possible to establish a clinical staging system distinguishing 2 groups. One, where the disease was severe and almost always fatal, often included the combined symptoms of thrombocytopenia, spontaneous anemia, jaundice, hepatosplenomegaly, respiratory insufficiency and absence of osteolytic lesions. The other, with a favorable prognosis, was characterized by skin lesions, diabetes insipidus, exclusively radiological pulmonary involvement and multiple bone lesions. In cases where death did not occur, DHX was often chronic, frequently persisting for 2 years or more and leading to serious sequelae such as diabetes insipidus, growth stunting, intellectual retardation, blindness or deafness.

Adolescent↗
PubMed1979

Human alveolar macrophages spontaneous reduction of BSPT salt.

Alveolar macrophages of non smoking and smoking human adults reduce BSPT salt spontaneously. The staining obtained is located on three cell membrane systems: the endoplasmic reticulum, the Golgi apparatus and the nuclear envelope. Methylene blue MB inhibits BSPT reduction. The smokers alvelolar macrophages have less positivity than those of the non smokers. The endogenous cell substrate revealed in this work is the initial common pathway of two different oxidative chains bounded to the microsome. One acts with cytochrome P 450 for chemical detoxification by hydroxylation, the other one acts with cytochrome B5 for lipid oxidation or peroxidation and both may be connected with the cell bactericidal system.

Benzothiazoles↗
PubMed1979

[A fatal syndrome associating a micromelic dwarfism, an ichthyosiform skin disorder and a severe combined immunologic deficiency. Report of a case and survey of the literature (author's transl)].

Congenital immunologic deficiencies and congenital dwarfisms represent two seemingly unrelated disorders. Here is reported the tenth case of a definite congenital and fatal syndrome associating a severe combined immunologic deficiency and a micromelic dwarfism, affecting mainly the proximal limbs, as well as an ichtyosiform and furrowed skin disorder. Although the adenosine deaminase activity has not been determined in this patient, a 4-month old boy, this syndrome seems to be different from cases of ADA negative SCID. The associated impairment of growth and immunity emphasizes once more the close genetic linkage existing between the development of the skeleton and the lymphoid tissue.

Adenosine Deaminase↗
PubMed1979

Multifocal myocardial necrosis and fibrosis in pancreatic diseases of children.

From a review of 2,000 autopsies of children, 16 cases of extensive necrosis and scarring fibrosis of the myocardium were found. These lesions involved mainly the left ventricle and spared the endocardium, the pericardium, and the coronary vessels. These necrotic of fibrotic heart lesions were found to be closely associated with various pancreatic diseases: cystic fibrosis (11 cases), pancreatic lipomatosis (2 cases), extensive small bowel resection (3 cases, 2 of which were associated with acute interstitial pancreatitis). To explain these unexpected associations, two hypotheses can be put forth: (1) The lack of absorption of some presently undetermined substances indispensable for the correct trophicity of the myocardium, and (2) the release in the blood of proteolytic enzymes with consecutive activation of phlogistic substances such as kinins.

Acute Disease↗