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Biomedical subjects

C Nelson-Piercy

Publications and source records attributed to C Nelson-Piercy.

50 records · Page 3Linked to original sources
PubMed1994

Do we know how to screen for gestational diabetes? Current practice in one regional health authority.

To review current practice for screening and diagnosis of gestational diabetes (GDM) in the North East Thames health region, clinical directors and other relevant individuals in all 17 obstetric units within NE Thames were interviewed personally. Additional information was obtained from local midwives, diabetologists, and chemical pathologists. Thirteen centres had a formal policy for screening and diagnosis of GDM. One centre ran two policies. Six of 18 centres performed a routine blood glucose (BG) screen on all pregnant women, proceeding to OGTT either on the basis of raised BG alone (3 centres), or on the basis of raised BG and/or clinical risk factors (3 centres). Of the remainder, 10 performed a diagnostic test (OGTT or equivalent) in all those with risk factors, and 2 via an intermediate screening BG. The choice and interpretation of screening and diagnostic tests varied considerably. Six centres used random BG, with cut-off ranging from > 5.8 mmol l-1 to > 9.0 mmol l-1, one used a single fasting BG > 5.0 mmol l-1, and another a 50 g oral glucose challenge (1 h level > 8.0 mmol l-1). Diagnosis of GDM was based on a 75 g (13 centres) or a 50 g OGTT (2 centres), while 1 used a standard mixed meal, and another a timed post-prandial glucose sample. Timing of tests ranged from booking to 36 weeks gestation and the diagnostic cut-off levels for GDM varied (fasting: 5.0-8.0 mmol l-1; 2 h: 6.0-10.1 mmol l-1).(ABSTRACT TRUNCATED AT 250 WORDS)

Diabetes, Gestational↗
PubMed1994

Effect of a new oral somatostatin analog (SDZ CO 611) on gastric emptying, mouth to cecum transit time, and pancreatic and gut hormone release in normal male subjects.

Sixteen healthy male volunteers participated in a randomized, double blind, parallel groups study. Subjects received either 1 or 5 mg SDZ CO 611 (a new, orally active somatostatin analog) twice daily over a 14-day period and acted as their own controls. Gastric emptying of 99mTc and mouth to cecum transit time, as measured by the breath hydrogen technique, after a mixed meal containing lactulose and 99mTc-diethylenetriaminepentaacetate, were assessed once before, twice during, and once after the period of study medication. Gastric emptying of 99mTc was significantly accelerated by the higher dose of SDZ CO 611, whereas mouth to cecum transit time was prolonged by the drug in a dose-dependent manner. Both doses of SDZ CO 611 led to suppression of the fasting level and postprandial release of several gastrointestinal and pancreatic hormones. This effect was more marked in those subjects taking 10 mg/day of the study medication. Motilin and pancreatic polypeptide were the most sensitive to the inhibitory actions of the analog. Glucose tolerance was significantly impaired by the 10-mg dose of the drug. We conclude that this new, orally active derivative of somatostatin is as effective on the gastrointestinal tract as the sc somatostatin analog octreotide. It would, therefore, be a useful advance in the treatment of gastroenteropancreatic tumors.

Administration, Oral↗
PubMedDate not supplied

Respiratory disease in pregnancy.

Respiratory disease is common in pregnancy, and becoming more so: asthma, pneumonia and tuberculosis are all increasing in frequency. This review discusses these conditions and their relationship to pregnancy, as well as considering briefly some rarer diseases.

Female↗
PubMedDate not supplied

Obstetric physicians: are they needed? The workload of a medical complications in pregnancy clinic.

Obstetric physicians are physicians whose training and particular expertise lie in the care of the medical complications of pregnancy. We present an audit of the work of our bi-weekly obstetric medicine clinic at Queen Charlotte's Hospital, London, over a 10-month period from July 1994 to April 1995 inclusive, and discuss the need for obstetric physicians, with reference to individual medical conditions which complicate pregnancy.

Female↗
PubMedDate not supplied

Obstetric thromboprophylaxis.

Thromboembolism in pregnancy is a major cause of maternal mortality. Pregnancy, particularly caesarean section, increases the risk of thrombosis. This article discusses the risk factors, the drugs used and the indications for prophylaxis of thromboembolism in pregnancy.

Anticoagulants↗
PubMedDate not supplied

Asthma in pregnancy.

Explore the source record for details and available documents.

Acute Disease↗