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Biomedical subjects

C Nava

Publications and source records attributed to C Nava.

At least 37 records · Page 2Linked to original sources
PubMed1982

Effectiveness of penicillin irrigation in control of infection in sutured lacerations.

We studied the incidence of infection in lacerations in a controlled, double-blind, Armitage sequential clinical trial. After standard prescribed preparation of the wound area, and immediately before suture, each laceration was flooded with the 10 ml content of a numbered, amber glass vial. Half of the vials contained a solution of 0.9% NaCl; half contained a 5% solution of sodium benzyl penicillin. No other factors were controlled. A single observer made the determinations of presence or absence of infection, purulent or nonpurulent, early and late after suture. After study of 260 lacerations the study indicated a clear superiority of penicillin over saline in lowering the incidence of infection with a statistical significance of p less than 0.00005. In a sample of this size the 95% confidence limits of the magnitude of the superiority of penicillin cover a wide range, but it appears that two out of three or three out of four infections can be averted merely by flooding the wound with penicillin immediately before suture.

Clinical Trials as Topic↗
PubMed1982

Effect of bromocriptine and metergoline in the treatment of hyperprolactinaemic states.

The effects of bromocriptine or metergoline treatment were evaluated in 80 hyperprolactinaemic patients (62 women and 18 men). The patients were subdivided into 4 groups: group A) 16 women with idiopathic hyperprolactinaemia; group B) 19 women with untreated Prl-secreting microadenomas; group C) 27 women with unsuccessfully operated prolactinomas; group D) 18 men with unsuccessfully treated macroprolactinomas. Sixty-eight patients were given bromocriptine (2.5-20 mg/day) for 3-58 months and 33 patients were given metergoline (4-16 mg/day) for 3-19 months. Bromocriptine and metergoline were equally effective in the treatment of functional hyperprolactinaemia and of untreated microadenomas, while bromocriptine showed a more potent Prl-lowering effect than metergoline in patients with higher Prl levels and large prolactinomas; both drugs restored the gonadal function to a similar extent, though metergoline was effective in some cases, even in the absence of full Prl suppression. Bromocriptine seems to exert an antitumoral effect, as documented by CT scan in some patients with macroadenomas, but the precise role of both drugs with respect to dose, length of treatment and effectiveness after withdrawal needs to be evaluated further.

Adenoma↗
PubMed1982

PRL action on E2 ovarian secretion.

5 Amenorrhea hyperprolactinemic women in previous intermittent treatment with bromocryptine, received bromocryptine for three periods of 5, 4, 3 days; each treatment phase was followed by a ten days suspension. During treatment and during suspension FSH, LH, PRL and E2 were tested. There was no significative variation of FSH and LH; PRL lowered during treatment and reached basal values during suspension. Ovarian response (E2) varies with PRL levels. There was a statistically significative negative correlation between PRL and 17-beta-E2.

Adult↗
PubMed1982

DNA polymerases in irradiated regressing or regrowing EMT6 tumor.

The EMT6 tumor of Balb/C mice was studied in vivo for irradiation response. It showed a typical, progressive Gompertzian growth mode in control tumors, and, after irradiation with 2000, 4000 or 6000 rad, a regression and regrowth pattern. This solid tumor model was studied with serial DNA-polymerase (DNA-P) alpha and B assays after irradiation-perturbed growth. The DNA-P activity was traced during growth and injury-regrowth to study its behavior as a potential marker for tumor activity. DNA-P alpha level fell after high dose irradiation, remained low during the early regeneration period, and rose again after a regrowth pattern was established. The changes in activity followed DNA-S activity by H3TDR uptake. DNA-P B activity did not change after irradiation.

Animals↗
PubMed1980

EMT6 solid tumor growth, DNA synthesis and DNA polymerase activity.

Serial DNA-polymerase-alpha and -beta enzyme level measurements were made during the growth of the EMT6 solid tumor. The determinations were correlated with DNA-synthesis in the tumor as measured by 3H-TdR labeling. The DNA-alpha polymerase levels were initially found to be low during early exponential growth phase, but to rise midgrowth to peak and to remain elevated thereafter until an advanced growth stage was reached. DNA-beta polymerase did not change during this entire observation period. DNA synthesis as measured by 3H-TdR uptake was greatest early in tumor growth and fell in midexponential growth phase. This pattern indicates that these two processes are not tightly coupled in the process of localized tumor growth.

Animals↗
PubMed1980

Serum prolactin levels during inhibition of lactation by cyclofenil.

Inhibition of lactation is now usually achieved by the use of dopaminergic or antiserotoninergic drugs. An interesting, alternative approach, however, is represented by the use of antiestrogenic agents, though their mechanism of action is still uncertain. We have given cyclofenil at daily doses of 1200, 800 and 600 mg to a total of 100 post-partum women who required not to lactate. The clinical results were excellent or good in 83 women, fair in 9 and poor in 8. After 3, 5, and 7 days of treatment serum prolactin levels of treated women, if compared with those of control group, showed a decrease ranging from 25 to 27%, from 42 to 44%, and from 60 to 64% respectively. Blood coagulation, as judged by several laboratory parameters, did not show abnormal changes in any subject treated with cyclofenil.

Cresols↗
PubMed1979

[Direct skin tests in the prevention of allergic reactions in surgical patients (500 cases)].

The methodology used to diagnose drug allergy in 500 surgical patients is described. After an introduction in which the choice of this method is justified, the used methods are shown in detail with the tested active pharmacological principles (it is a group of drugs for pre, intra and post-surgery use). The tested patients have been clinically watched during all their stay in hospital. The results achieved are shown, as well as the good mutual relation between anamnesis and clinical progress with the answers obtained from the tests. The detailed analysis of skin-reactions showed that positive answers against penicillin (in more than 37% of the tested cases) clearly prevailed over other drugs (petidinum about 12%; propanididum about 10%) etc. Skin-test positivity against prometazinum (6%) is stressed as being quite considerable, considering its prevalent anthistaminic pharmacological effect. The work ends showing how this method, if correctly used, can give good results which can be compared with the results achieved by other more sophisticated methodologies. The kind of test is recommended to be adopted by other hospitals to reduce the incidence of immunological pathogenesis diseases which is more and more frequent.

Drug Hypersensitivity↗