Biomedical subjects

C Naito

Publications and source records attributed to C Naito.

At least 73 records · Page 4Linked to original sources

PubMed1975

[Concepts and classification of hyperlipidemia and hyperlipoproteinemia with special reference to the classifications according to Frederickson and WHO].

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Cholesterol↗

PubMed1975

Effect of glucose on lipolysis and on release of lipolytic products in isolated adipocytes.

Isolated adipocytes were prepared from epididymal adipose tissues removed from rats which had been fed or starved for 48 h (fed adipocytes or fasted adipocytes). These cells were incubated at 37 degrees C for 90 min in media containing 0, 3, or 30 mM glucose, with or without norepinephrine (1.0 mug/ml). Then the concentrations of free fatty acids (FFA) and free glycerol (FG) in the total mixture (medium plus cells) and in the medium alone were measured. Addition of glucose to the medium increased the total PG, presumably by increasing the basal lipolysis, and it decreased the intracellular retention ratio of FG (the ratio of intracellular FG to total FG). Addition of glucose did not change the total FFA, but decreased the FFA/FG ratio, presumably by increasing reesterification. The increase in FG and decrease in the FFA/FG ratio on addition of glucose were greater in fed than in fasted adipocytes. The intracellular retention ratio of FFA also decreased on addition of glucose. Glucose enhanced norepinephrine-induced lipolysis (release of free glycerol), and this effect of glucose was greater in fasted adipocytes. However, the increase in FFA in fasted adipocytes induced by norepinephrine was not altered by addition of glucose. In fed adipocytes norepinephrine decreased the total FFA in the presence of glucose. Reesterification of FFA following norepinephrine was increased by addition of glucose. Norepinephrine decreased the intracellular retention ratios of FG and FFA in the presence of glucose. These results suggest that the passage of the lipolytic products, FFA and FG, through the cell membranes may not occur by simple diffusion, but may require energy.

Adipose Tissue↗

PubMed1975

Characteristics of serum lipid and lipoprotein patterns in patients with coronary sclerosis and with the slightest hyperlipidemia.

1. Serum lipid and lipoprotein patterns of subjects with/without coronary sclerosis and having less than 300 mg/100 ml of serum total cholesterol were analyzed. Subjects woth coronary sclerosis were classified into 2 groups, myocardial infarction (MI) group and coronary sclerosis (CS) group, in accordance with the criteria for the diagnosis of coronary sclerosis established by the special study group of the Educational Ministry in 1960. 2. While serum total cholesterol was higher in the MI group than in the other groups, there was no difference in total cholesterol concentration between the CS group and the control. However, the concentration of free cholesterol, triglycerides, total phospholipids and total lipids increased in the control, the CS and the MI group in this order. 3. The percent concentration of pre-beta and beta and the ratio of beta/alpha and pre-beta+beta/alpha increased in the control, the CS and the MI group in this order. Type IIb hyperlipoproteinemia was observed more frequently in the MI group than in the control one. Type IIa and IV hyperlipoproteinemia did not change into any other phenotypes, but Type IIb changed occationally into Type IIa. 4. So called extra pre-beta lipoprotein was observed more frequently in the CS and MI groups than in the control one. 5. These results suggested that even slight changes in serum lipid and lipoprotein patterns might be related to atherogenecity.

Adult↗

PubMed1975