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Biomedical subjects

C N Lewis

Publications and source records attributed to C N Lewis.

14 recordsLinked to original sources

The synthesis of novel matrix metalloproteinase inhibitors employing the Ireland-Claisen rearrangement.

Matrix metalloproteinase inhibitors of general formula (1) were synthesised by a route involving an Ireland-Claisen rearrangement which enables systematic modification of the substituent alpha to the hydroxamic acid. An analogue (12c) possessing an alpha-cyclopentyl group is a potent broad spectrum inhibitor that displays high and sustained blood levels following oral dosing in both the rat and marmoset ex-vivo bioassays. This compound and analogues are also potent inhibitors of TNF alpha release.

Administration, Oral↗

Synthesis and biological evaluation of dihydroeptastatin, a novel inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

The total synthesis of the novel hydroxylated HMG-CoA reductase inhibitor dihydroeptastatin (7) is described. The key C-3 hydroxyl group is introduced via a Baeyer-Villiger reaction on the methyl ketone 17 which is obtained in three high-yielding steps from the known tricyclic lactone 12. In an isolated enzyme assay dihydroeptastatin had a similar IC50 to mevinolin but in cellular assays using Hep G2 and HES 9 cell lines, dihydroeptastatin was much less potent. No selectivity between the two cell lines was observed.

Animals↗

Psychological assessment of an artist and impostor.

A Rorschach record and a narrative poem are examined to determine how imagination expresses the psychological trauma of being exposed as an impostor. The subject had been trained as a medical corpsman and deceived people under the grandiose fantasy of being a doctor. The role of the impostor physician is seen as an imaginative identity that was designed with an adaptive purpose. A Jungian analysis of his suicide attempt and the Rorschach suggest that the impostor role was a masculine compensatory fantasy that served as a counterforce to negative maternal imagery, linked to death, that is present in his imagination.

Adaptation, Psychological↗

Clinical, hematological, and biochemical features of Hb SC disease.

Twenty-seven patients were seen and followed at our Sickle Cell Center over a period of seven years. Their clinical, hematological, and biochemical features were determined and compared to those of patients with sickle cell anemia who were concurrently investigated. The data indicate that the mild anemia of hemoglobin (Hb) SC disease is slightly microcytic and hyperchromatic. Parameters of hemolysis and the complications of chronic hemolytic anemia (cholelithiasis, leg ulcers, hepatomegaly, and cardiomegaly) are milder in Hb SC disease than in sickle cell anemia. Asplenia and its sequelae (increased platelet count and reduced serum IgM levels) are less frequent in Hb SC disease. Cerebrovascular accidents and the decreased leukocyte alkaline phosphatase scores are similar in both diseases. Thromboembolic complications, retinopathy, and renal papillary necrosis are more frequent in Hb SC disease.

Adolescent↗

Psychological resolution of homicide after 10 years.

The projective imagery, artwork, and behavior of an artistically trained psychiatric patient are presented 10 years after having committed a murder. The case is examined to see whether the Rorschach responses and the artist's choice of subject matter demonstrate the repetition compulsion familiarly associated with trauma. Additionally, does psychotherapy in which the crime is remembered serve as a stimulus to these other forms of repetition? Our case shows evidence of a continuing psychological struggle to express or deny his involvement in the murder, with phases of limited resolution.

Adaptation, Psychological↗

Serum immunoglobulin levels in patients having sickle cell syndromes.

Serum immunoglobulin concentrations were measured for 44 patients who had sickle cell syndromes and for 19 normal black individuals. Most patients who had sickle cell syndrome had significantly elevated IgA levels. In addition, patients who had sickle cell anemia had elevated IgG levels, and patients who had sickle-beta-Thalassemia or other sickle combinations (SC, SD, SO) had significantly elevated IgM levels. None of these patients had a monoclonal gammopathy. The elevated immunoglobulin levels could be the result of chronic reticuloendothelial stimulation by chronic extravascular hemolysis or by potentiation by the inflammation secondary to cholecystitis and cholelithiasis. The reason patients with sickle cell anemia do not have increased IgM levels could be due to their functional asplenia.

Anemia, Sickle Cell↗

Murder will out.

A 1974 showing of more than 200 oils and water colors at the Tate Gallery, London, has led to a revival of interest in the 19th century English painter, Richard Dadd (1817 to 1886). In 1843, Dadd killed his father, cutting his throat, because he believed him to be the devil in human form. On a trip to the Near East, Dadd became deluded that the Egyptian god Osiris was directing him to eliminate the devil's influence. Four months after he returned to London he murdered his father, and was institutionalized for the last 43 years of his life. We advance the hypothesis that one particular painting. 'The Fairy Feller's Master-Stroke,' symbolically re-enacts the murder and makes talion restitution. The painting shows minute attention to detail and altogether occupied the artist for 9 years. He also made a water color copy of it entirely from memory, and wrote a 22-page poem explaining the picture with the title, 'An Elimination.' We suggest that this hints at the same theme of undoing. Some art critics have seen in Dadd's other art works a projection of his inner feelings, especially a series of more than 30 water colors entitled 'Sketches to Illustrate the Passions,' amongthem 'Murder,' 'Anger,' 'Hatred,' 'Grief,' and 'Melancholy.' We construe these to support the thesis of redoing and undoing following the trauma of murder. We also mention Dadd's reminiscing, visible in his art, and its usefulness in reaffirming his self-identity. In the art work of Dadd's last 25 years, violent scenes are remarkably absent. Instead, imaginary landscapes and seascenes--the subject matter of his earliest adolescent art--reflect an inward absorption in and continuity of lifelong interests. We suggest that the long process of painting 'The Fairy Feller's Master-Stroke' recapitulated and made restitution for the murder, encapsulating it so that compulsive expression of violent ideation was largely reduced, allowing other memories and activities to be engaged and expressed.

Art↗

Feedback EEG reactivity and the social responsivity of psychiatric patients.

Social responsivity and spontaneous attentiveness to the environment were evaluated in a heterogeneous sample of psychiatric patients. Each of the 22 male inpatients was first seen in a nondirective, taped interview and then tested with a feedback electroencephalogram (EEG) measure of attention. It was predicted that those patients who were more responsive in the interview a) would initially be more reactive in terms of their EEG response to visual stimulation; and b) would maintain their attentiveness longer than would the less socially responsive group. The results indicated significant correlations (from +.49 to +.64) between the measures of interview responsivity and attentional reactivity for ranks across all Ss. In addition, when the sample was divided into two separate groups of high vs. low social responders, group differences were found with respect to both initial EEG reactivity and the measures of persistence of attentiveness. The results appear to have implications for the "trait" concept within personality theory, and less directly, for aspects of psychoanalytic theory. In addition, the clear group differences obtained on a variety of attentional parameters underline the potential usefulness of the method of feedback in the study of EEG and behavior.

Adult↗