[Acquired adenolipoidosis resembling Launois-Bensaude syndrome in 2 alcoholics].
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Alcoholism↗
Biomedical subjects
C Monier
Publications and source records attributed to C Monier.
Isolation-induced social behavioural deficit in mice and its relation to stimulant drugs.
The effect of stimulant drugs was studied in isolated mice on spontaneous motor activity and in the isolation-induced social behavioural deficit test. Amphetamine, atropine, caffeine, oxolinic acid and RU 24969 all increased significantly the spontaneous locomotor activity. The social behavioural deficit was reduced with RU 24969, unchanged with atropine and oxolinic acid, increased with amphetamine and caffeine. These results show that no relation exists between the effect of a drug on spontaneous motor activity on one hand and the social behavioural deficit on the other hand; they confirm the high specificity of the effect of agonists of the 5-HT1B receptors in the social behavioural deficit test; they suggest that an increase in the social behavioural deficit as elicited by amphetamine and caffeine may result from an increase in attention and anxious vigilance.
Animals↗
The visual cortical association field: a Gestalt concept or a psychophysiological entity?
The receptive field of a visual neurone is classically defined as the region of space (or retina) where a visual stimulus evokes a change in its firing activity. Intracellular recordings in cat area 17 show that the visually evoked synaptic integration field extends over a much larger area than that established on the basis of spike activity. Synaptic depolarizing (dominant excitation) responses decrease in strength for stimuli that are flashed at increasing distances away from the centre of the discharge field, while their onset latency increases. A detailed spatio-temporal analysis of these electrophysiological data shows that subthreshold synaptic responses observed in the 'silent' surround of cortical receptive fields result from the intracortical spread of activation waves carried by slowly conducting horizontal axons within primary visual cortex. They also predict that a perceptual facilitation may occur when feedforward activation produced by the motion signal in the retina travels in phase in the primary visual cortex with the visually induced spread of horizontal activation. A psychophysical correlate has been obtained in humans, showing that apparent motion produced by a sequence of co-linear Gabor patches, known to preferentially activate V1 orientation selective cells, are perceived by human observers as much faster than non co-linear sequences of the same physical speed.
Animals↗
[Clinical diagnosis and standardized evaluation of borderline personality: preliminary report].
A sample of 36 patients considered by French clinicians as suffering from a borderline personality disorder was evaluated using the International Personality Disorder Examination, the Diagnostic Interview for Borderline-Revised, and the Minnesota Multiphasic Personality Inventory. First, global descriptive analysis of the sample elicited the socio-demographic and standard clinical characteristics of the borderline individuals. After diagnostic evaluation, the sample appeared to be quite homogeneous with 25 of the 36 patients evaluated (69.5%) being defined as borderline by two of the three diagnostic systems: ICD 10, DSM III-R and Gunderson (15/36 = 41.5% of patients were defined as borderline by all three systems). It is the types of BL personality co-diagnoses which differentiated the BL subjects in the sample from those classically described in the international literature, since the most frequent personalities were the Dependent and Avoiding ones, not the Antisocial, Histrionic, Narcissistic or Schizotypic personalities of the DSM III-R. ICD 10 elicited the same significant prevalence of Anxious and Dependent personalities. Lastly, the patients diagnosed as borderline both by clinicians and by all diagnostic systems (forming the sample "core") were compared with the rest of the sample with regard to socio-demographic, clinical and diagnostic characteristics. A few hypotheses are proposed on the type of variables that may permit to discriminate between these two types of patients.
Adult↗