[Food preservation by irradiation].
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Food Inspection↗
Biomedical subjects
C Mohr
Publications and source records attributed to C Mohr.
Changes of the organotypic retinal organization in Borna virus-infected Lewis rats.
Retinae of Borna disease virus (BDV)-infected Lewis rats were investigated with emphasis on long-term changes in organotypic tissue organization and glia-neuron relationship. Virus inoculation was attained via intracerebral BDV injection. Following survival times ranging between two and eight months, the retinal thickness was reduced up to one third of that of controls. Photoreceptor segments were completely extinguished and the number of neurons was dramatically reduced. The typical laminar organization of the retina was largely dissolved. Electron microscopy revealed severe spongy degeneration. Large numbers of activated microglia and macrophages were found, both cell types performing very active phagocytosis. The microglial cells expressed an extraordinary phenotype as characterized by large numbers of processes, with some of them penetrating the endfeet of Müller cells and others establishing highly complex interdigitations with vacuolized swellings and endings of neuronal processes. Müller cells were not reduced in number but displayed clear indications of gliosis such as alterations in the immunoreactivity for filament proteins and glutamine synthetase, significantly thickened stem processes, and an altered pattern of K(+) currents in patch-clamp recordings. These findings demonstrate for the first time long-term neuron-glia interactions in the retina of BDV-infected rats. Moreover, the data contribute to our knowledge on structural and functional alterations accompanying persisting virus infection in the central nervous system.
Animals↗
[Persistent Lactobacillus casei subspecies rhamnosus bacteremia in a 14 year old girl with acute myeloid leukemia. A case report].
The present clinical observation is related to a 14-year-old girl suffering from acute myeloid leukemia. The clinical course was complicated by episodes of severe enterocolitis, E. coli- septicemia, pancreatitis and pneumonia. In the course of continued cytostatic and antibiotic treatment a persistent asymptomatic Lactobacillus casei subsp. rhamnosus-bacteremia became detectable by a total of 18 blood cultures. Microbial cultures of the faeces revealed colony-forming unites of this germ in orders of 10(9)/g. Antibiotic eradication attempts according to the resistogram were not successful. The Lactobacillus-bacteremia disappeared only after 13 months when the cytostatic therapy was terminated. An adjuvant influence of the Lactobacillus infection on the outcome of the underlying disease cannot be excluded.
Adolescent↗
Ten-year experience in oral implant rehabilitation of cancer patients: treatment concept and proposed criteria for success.
Between 1988 and 1997, 18 irradiated patients (group 1, 83 implants) and 22 nonirradiated patients (group 2, 92 implants) received resection of the cancer-involved mandible and floor of the mouth and subsequently underwent mandibular rehabilitation with endosseous implants. Implant-supported prostheses were placed in 26 patients, while 13 patients received implant-tissue-supported prostheses. Between 1988 and 1991, patients were restored with implant-tissue-supported prostheses (based on 2 to 4 implants). This strategy was later changed because of the development of denture-related lesions. Since 1992, group 1 patients have been restored exclusively with implant-supported prostheses on 5 to 6 implants; group 2 patients have been rehabilitated alternatively with implant-tissue-supported prostheses on 4 implants. Special criteria for determining the success of implant-supported maxillofacial prostheses were developed. With a mean follow-up period of 37 months, 160 implants (91%) were clinically osseointegrated. Both types of restorations provided sufficient oral rehabilitation. However, only completely implant-supported prostheses avoided soft tissue ulcers. The cumulative success rate was approximately 75% after 7 years for group 1 patients and about 86% after 10 years for group 2 patients. The success rates for implants placed after the change in strategy were approximately 86% (group 1) and 94% (group 2) after 5 years. Based on these experiences, it is suggested that irradiated patients should be restored with exclusively implant-supported prostheses, without any mucosal contact.
Adult↗
[Effects of oral administration of bifidobacteria on intestinal microflora in premature and newborn infants].
In a prospective, randomised study the effects of orally administered bifidobacteria on the intestinal microflora were investigated in 100 preterm and term neonates under intensive care conditions during the first 21 days of life. The 50 infants (group with bifidobacteria) received lyophilized bifidobacteria (Töpfer Bifidus) via nasogastral tube with an initial dosage of 3 times daily 1.25 x 10(8) bifidobacteria on day 2 of life and a daily dosage of 6 times 1.25 x 10(8) bifidobacteria on day 3 until day 21 of life. The other 50 infants (control group) did not receive bifidobacteria. The preterm and term neonates were fed either with pasteurized mother's milk or milk from healthy female donors (n = 79) or with an infant formula (Alfaré, n = 13) or initially with Alfaré and thereafter with mother's milk (n = 8). The intestinal microflora of preterm and term neonates under intensive care conditions could be influenced by the oral administration of bifidobacteria. The administration of bifidobacteria resulted in the group of inoculated infants in a significantly earlier colonization of bifidobacteria (8.1 +/- 3.9 days of life) than in the control group (11.3 +/- 4.7 days of life). On day 7 a bifidobacterial dominance (> 90% of the intestinal microflora) could be found in 26% of infants with inoculation of bifidobacteria and only in 2% of the control group (p < 0.001). These significant differences could be shown until day 21 of life. A difference in septicemia frequency between the two groups could not be demonstrated. At the beginning of the infection a bifidobacterial dominance was found in only one of 23 cases of septicemia.
Bifidobacterium↗
A new application for craniofacial implants: wigs.
PURPOSE: The purpose of this study was to describe a new application of craniofacial implants, as anchoring elements for wigs. MATERIALS AND METHODS: In two patients, a split-skin graft was used to close a soft tissue defect in the occipital, parietal, temporal, and frontal region (defect size of 10 cm x 33 cm and 10 cm x 14 cm). Six titanium implants were placed in each patient. Six months after implant placement, abutment connection was performed and titanium magnets were adapted. Subsequently, an implant-retained wig was constructed. RESULTS: In a follow-up period of between 10 and 22 months no implant failed. The incorporated wigs effectively retain a functionally and cosmetically successful craniofacial rehabilitation. CONCLUSION: Despite these successful treatments, further research is needed before craniofacial implants as anchoring elements for wigs can be considered a standard option in the rehabilitation of craniofacial alopecic defects.
Adolescent↗
Implant-supported mandibular telescopic prostheses in oral cancer patients: an up to 9-year retrospective study.
PURPOSE: The aim of this retrospective study was to present the results of implant-supported telescopic prostheses in the mandible after removal of malignant tumors. MATERIALS AND METHODS: Between 1991 and 2000, 24 patients with squamous cell carcinoma (16 irradiated, eight nonirradiated) underwent mandibular rehabilitation with implant-supported telescopic prostheses. A total of 111 dental implants were placed. Treatment complications were observed. The cumulative survival rates of the implants and prostheses were evaluated by lifetable analysis. RESULTS: Within a mean follow-up period of 30 months (1 to 108 months), only three implants failed. All other implants are still in function. Of 24 patients, 23 were satisfied with their implant-supported telescopic restorations. Soft tissue, implant, or prosthetic complications occurred very rarely. The cumulative implant survival rate was about 97% and the cumulative prosthesis survival rate was about 95% at 9 years. CONCLUSION: Implants and implant-supported telescopic maxillofacial prostheses can successfully remain in function over a long period. Increased implant and prosthetic complications should not be expected. Therefore, telescopic implant attachments seem to be very useful as a treatment option for prosthetic restoration of the mandible in tumor patients.
Adult↗
[Inverted papilloma: implications for the oral and maxillofacial surgeon].
7 patients with inverted papillomas of the maxillofacial area were subjected to a post-treatment evaluation. Inverted papillomas were found in maxillary and frontal sinuses, ethmoid cells, nasal septa and as isolated lesions in the mucosa of the mandibular alveolar process. Apart from an inverted papilloma, one patient also had a mucoepidermoid carcinoma. The tendency to recur correlated well with the surgical approach. Radical removal of the mucosa must be called for as primary therapy in the paranasal sinus area. In order to safely exclude a concurrent carcinoma, the entire resected material must be examined histologically.
Adult↗
[Clinical features and treatment of cutaneous carcinoid].
An exemplary case of a 67-year-old patient with multiple cutaneous metastases of a pulmonary carcinoid primary tumor is presented. The cardinal symptom was severe painfulness of the skin tumors. With chemotherapy the tumor disease advanced. In presenting this case and providing a review of the literature, the primary importance of surgery even in the case of a metastasizing carcinoid is emphasized.
Aged↗
[Taurodontism in patients with sex chromosome anomalies].
Out of a population of 61 patients with sex chromosome aberrations we could examine 25 patients with Klinefelter's syndrome and one female patient with triple X syndrome for taurodontism. Taurodontic molars were found in 6 out of 25 patients with Klinefelter's syndrome and in the patient with triple X syndrome.
Adolescent↗
[Preoperative radio-chemotherapy and radical surgery for advanced carcinomas of the oral cavity. 4-year results of a prospective therapy study with DOSAK].
Based on the postoperative data evaluated in September 1989, the results of a regional prospective treatment study conducted by the DOSAK on preoperative radio-chemotherapy and radical surgery for carcinomas of the oral cavity and the oropharynx are presented. In the univariate analysis the histologic lymph node findings after pretreatment, the histologic grading, and the TPI correlated well with the survival rates. The multivariate analysis confirmed that the histologic demonstration of vital tumor cells in the neck lymph nodes after the end of pretreatment is of grat prognostic relevance. The histologic degree of differentiation, the demonstration of vital tumor cells in the primary tumor area after pretreatment and the length of time between radiotherapy and surgery were of secondary importance.
Adult↗
[The question of midface growth inhibition following retinoblastoma treatment in early childhood].
99 patients treated for bilateral retinoblastomas in the University Hospital of Essen between 1965 and 1983 were followed up for midface growth inhibition for an average period of 15 1/2 years. Depending on the type of treatment employed the patients were divided into four groups: Local tumor treatment using cryotherapy or laser techniques, ophthalmectomy alone, radiotherapy alone, and combined ophthalmectomy and radiotherapy. Statistically significant differences between the treatment groups were found regarding such symptoms as hypoplasia of the zygomatic bone, hypoplasia of the transversal orbit, hypoplasia of the temporal fossa, hypoplasia of the root of the nose as well as hypotelorism and enophthalmos. Combined surgery and radiotherapy caused the most severe growth disorders, followed by radiotherapy alone and ophthalmectomy alone. With local treatment detectable growth disorders were observed, if at all, only as a result of contralateral radiation scatter. Orthovoltage radiotherapy was found to produce growth disorders of significantly higher severity than megavoltage radiotherapy.
Adolescent↗
[Preoperative irradiation, cisplatin sensitization and radical surgery of primarily operable carcinomas of the oral cavity. Results of a prospective DOSAK treatment study].
165 patients with carcinomas of the oral cavity or oropharynx, clinically appearing operable, were treated between 1985 and 1987 within the framework of a prospective multicenter study. The treatment concept consisted in preoperative irradiation with 32 Gy, cisplatin sensitization with 5 X 20 mg per m2 body surface area and subsequent radical removal of the primary tumor and the regional cervical lymph nodes. Regarding recurrence and survival rates the patient data were analyzed using one- and multi-dimensional statistical methods. The observed survival rates were compared with those assessed with the aid of the treatment-dependent prognosis index TPI (Platz et al. 1982). After 1 years the survival rates under the selected combination therapy were 12% and after 2 years 19% above the assessed survival rates under radical surgery alone.
Cisplatin↗
[Clinical and morphological features of intraoral mesenchymomas].
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Adult↗
[Clinical aspects and morphology of Merkel's cell tumors].
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Carcinoma↗
[The diagnostic value of NMR imaging in the paranasal sinus area].
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Humans↗
Concept of surgical and implant-supported prostheses in the rehabilitation of patients with oral cancer.
Thirteen irradiated and 14 nonirradiated patients were treated after resection of a malignant oral lesion. With a follow-up period of 26 months, 3 of 48 implants in nonirradiated patients and 4 of 57 implants in irradiated patients failed. In comparison to implant-tissue-supported prostheses, exclusively implant-supported prostheses demonstrated better results with regard to soft tissue trauma and function of the prosthesis.
Adult↗
Titanium implants in the zygoma as retaining elements after hemimaxillectomy.
Obturator prostheses require anchoring elements in the partially resected maxilla to provide stability and oronasal separation. Anchoring elements are usually overstressed because of the lack of collateral support. Intraoral titanium implants can provide additional retention and avoid mechanical overstress of the anchoring elements in the residual maxilla. Treatment with intraoral implants into the zygoma for the support of an obturator prosthesis is reported.
Dental Implantation, Endosseous↗