Biomedical subjects
Publications and source records attributed to C Mitchell.
In densely mapped and characterized chromosomes such as the X chromosome there are still regions which have a paucity of markers. One of these areas lies in the Xp11 region. Using human-rodent somatic cell hybrids we have assigned a newly isolated clone IB/D22 to the Xp11.1-p11.4 region.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
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This study presents a unique procedure for determining the critical duration and temporal summation function. With this procedure, duration as a parameter was used to determine the temporal summation characteristics of ten normal ears. An apparatus was constructed that permitted subjects to track threshold by modulating the burst width of a brief tonal stimulus. The apparatus permitted experimenter control of the rate of burst width modulation and interburst interval. The burst width could be continuously varied by the subject from 10 to 800 msec. Asymptotic regression indicated that the data were best fit to a simple power function of the form Y = AX(B). A logarithmic transformation was applied to the obtained durations, and slopes of integration were determined for each frequency. These values ranged between 6.3 and 10.2 dB/log unit time. Differences among frequencies were found to be significant. Critical durations were obtained for each subject, and these values were consistent with previous data indicating negligible temporal summation about 150 to 200 msec.
This paper describes the use of a welcoming group for patients in an acute psychiatric ward for older people. The importance of welcoming is discussed are the practical elements involved.
In the past, library personnel had trouble finding information for health and medical questions. Libraries must be sensitive to the private nature of medical questions and must be cautious not to provide misinformation or personal opinions. In this article, the author describes how a subscription to the Health Reference Center from the Information Access Company (Foster City, CA) solves these problems and more.
OBJECTIVE: To compare tympanic membrane temperature with pulmonary artery (PA) and rectal temperature (calibrated glass mercury) to determine consistency among measures. DESIGN: Convenience, within-subject, quasi-experimental. SETTING: Midwestern university-affiliated tertiary medical center. PATIENTS: 128 adult (18 years or older) patients admitted to the surgical intensive care unit with an age range of 18 to 90 years (mean 57 years). OUTCOME MEASURES: Tympanic, PA, and rectal temperature. INTERVENTION: Rectal and tympanic membrane temperatures were measured in 60 patients. PA and tympanic membrane temperatures were measured in 68 patients. RESULTS: Rectal and tympanic membrane temperatures were moderately correlated (r = 0.525). Mean rectal was slightly higher than mean tympanic membrane temperature (mean difference 0.19 degrees C). PA and tympanic membrane temperatures were highly correlated (r = 0.909). Mean tympanic membrane temperature was slightly higher than mean PA temperature (mean difference 0.42 degrees C). For PA temperatures, 57 (84%) of the differences were between 0 and +1 degree Celsius, whereas for rectal temperature, 23 (37%) were between 0 and +1 degree Celsius and 28 (47%) were between 0 and -1 degree Celsius. CONCLUSIONS: Tympanic temperature measurements would be an appropriate substitute for PA temperature if the PA catheter has been removed or the PA thermistor is nonfunctional. In addition, this study suggests that to effectively track temperature in a particular patient, the site for temperature measurement must be consistent.
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As management of acute illness shifts to the community from tertiary care centres, there is a need for community-based research into the delivery of health services. One author is the coordinator of a health services delivery research unit located in a community health centre as well as the director of research in the Department of Family Medicine at McMaster University. The other author is a member of the administration of the sponsoring institution. The research unit, created in 1994, has close links with the sponsoring hospital, a research centre and the faculty of health sciences at a nearby university. Its staff has grown from 2 to 12 members, mainly as a result of grant support. Its aim is to improve the delivery of community-based health services, and to this end it conducts research in collaboration with programs at the health centre, stakeholder groups, communities and institutions. Research projects have been undertaken in clinical guidelines, women's health, mature adults' health, medication use and new technologies for screening. As an example, concern about chlamydial infections in women in the community led to research into burden of illness, diagnosis, screening methods, test technologies, validation of guidelines and provider behaviors. In the future, funding will be a major concern. The authors contend that more funding from such agencies as the Medical Research Council of Canada should flow to community-based research.