The T and B lymphocytes were determined by the rosette test in the peripheral blood of 100 patients with internal chronic diseases with immune processes such as: chronic hepatitis, systemic lupus erythematosus, myasthenia gravis, chronic lymphocytic leukemia and lymphosarcoma. The values obtained were compared with those in 10 controls. The mean per cent values of the T lymphocytes in the controls were 33 (29-38%) and of the B lymphocytes 25.2 (16-43%). In the patients investigated the values varied, namely: in chronic hepatitis and systemic lupus erythematosus the T lymphocytes were generally low while the B lymphocytes were moderately high. In myasthenia gravis both T and B lymphocytes were below the control values. In chronic lymphocytic leukemias and lymphosarcomas the per cent values of the T lymphocytes were generally low while those of the B lymphocytes were high. The significance of these results for the immunologic implications of the lymphocyte populations is discussed and an attempt is made to correlate these data with the nucleologram variations.

B-Lymphocytes↗

PubMedDate not supplied

[Epidemiological studies of viral hepatitis with and without HB antigen by means of complex studies in families].

The results of an epidemiological and laboratory investigation on 242 adults and children, who had come in contact with patients suffering from viral hepatitis (in the family or outside it), showed the importance of family contact and the role of routes of transmission other than the parenteral and transfusional ones in viral hepatitis with positive HB antigen. Attention is likewise drawn to the importance of the laboratory tests (classical enzymatic tests and immunoelectrodiffusion) in the detection of epidemogenic sources, represented by the subclinical forms of infection.

Epidemiologic Methods↗

PubMedDate not supplied

Present-day possibilities of diagnosis and treatment of chronic liver diseases. Contributions of the research work in the "N. Gh. Lupu" Institute of Internal Medicine.

A short presentation is made of the investigations on chronic liver diseases carried out in the "N. Gh. Lupu" Institute of Internal Medicine--Bucharest from its foundation to the present day. The main courses of investigation (fundamental, diagnosis, prophylaxis, treatment) are specified, with emphasis on the achievements obtained within the general context of the progress of hepatology all over the world.

Chronic Disease↗

PubMedDate not supplied

[Psychological valences of the physician-patient relationship].

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Education, Medical↗

PubMedDate not supplied

Concentration of serum immunoglobulins in acute and chronic hepatic diseases. II. Viral hepatitis; time-dependent changes in immunoglobulin concentration.

Immunoglobulin (Ig) concentrations were determined on blood samples drawn of 6 occasions over a 2-month period from 38 young patients with viral hepatitis. The main and joint effects of sex and day factors on mean Ig levels were studied by using a 2-way ANOVA model. No distinct pattern of variation was observed for IgA, IgG and IgD, whereas the mean values of IgM showed a statistically significant variation throughout the study period. Female patients had significantly higher mean Ig values than males; for each Ig-class, however, the day-to-day variation was very similar in the two sexes, as reflected by an unsignificant sex-day interaction. The results suggest that serial measurements of IgM levels can be useful for identifying those patients at risk of developing chronic hepatitis and for an early detection of viral hepatitis in persons at very high risk of contracting this disease.

Acute Disease↗

PubMedDate not supplied

[Study of the prevalence and incidence of viral hepatitis in collectivities].

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Age Factors↗

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Prevalence and patterns of hyperimmunoglobulinemia in acute viral hepatitis convalescents.

The 99th-percentile values of a large control group were used to determine the frequency and patterns of hyperimmunoglobulinemia (HIg) in 119 convalescents from viral hepatitis in whom Ig quantitation was performed on two occasions within 6 1/2 months after their acute episode. The mean levels of IgG, IgA and IgM, but not of IgD, were significantly higher in convalescents than in controls. There was no significant difference (p greater than 0.1) in the overall frequency of HIg (at least one Ig-class value greater than or equal to 99th percentile of controls) between the initial (30.2%; n = 119) and repeat (20.6%; n = 97) samples, though differences in the distribution of HIg patterns occurred between the two samples. At the time of repeat testing, 7 out of 77 subjects with normo-Ig, but 13 out of 20 with HIg had clinical and/or laboratory abnormalities (p less than or equal to 0.001).

Acute Disease↗

PubMedDate not supplied

Study of lymphocyte reactivity in various stages of chronic liver disease following acute viral hepatitis.

Lymphocyte reactivity was studied in 210 subjects who had suffered from acute viral hepatitis, distributed into three lots according to the time-interval from the acute disease. The laboratory investigations included: study of the lymphocyte nucleolar apparatus (amount of nucleolar RNA, relative and absolute areas of lymphocyte nucleoli) and determination of the proportion of the rosette-forming B-cells. A marked increase of the nucleolar RNA amounts and of the B-cell count was observed in the lot of patients investigated after one to 10 years from the acute hepatitis, while in those who, after longer periods (more than 10 years) had developed a liver cirrhosis the values of these parameters were lower than normal. It is assumed that such changes could predict, already in the early stages, either the favourable course of the disease or its progress to chronicity; the hypersynthesis of lymphocyte nucleolar RNA would suggest the interference of these cells in the immune disorders implicated in the development of chronic liver disease.

Acute Disease↗

PubMedDate not supplied

Aspect of the evolution of viral hepatitis two years after the acute phase.

A group of 214 nonselected former patients with viral hepatitis of which 15 HBsAg negative and 62 HBsAg positive, was studied prospectively by following the evolutive variations between the first and second year after the acute phase of disease. In both groups the percentage of cured cases increased moderately but the evolutive process toward the chronic stage was observed to reappear in some of the cases apparently cured thus proving that the process of becoming chronic is not completed within 1 year after the acute phase. The percentage of chronic cases after HBsAg positive hepatitis is clearly higher than after HBsAg negative hepatitis the difference being more evident in active chronic hepatitis. The risk of becoming chronic is greater after HBsAg positive viral hepatitis with prolonged clinical forms and the HB antigen also persists longer in the serum. In conclusion the necessity of clinical and biologic control of all former patients with viral hepatitis for at least 2 years after the acute phase is strongly emphasized.

Adult↗