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Biomedical subjects

C Mion

Publications and source records attributed to C Mion.

At least 127 records · Page 7Linked to original sources
PubMed1984

[Renal response to acute expansion of the extracellular volume in renal transplant patients].

The response to acute isotonic saline loading (1 800 ml in 3 hours) was assessed in 12 normotensive and 11 hypertensive renal transplant recipients. Both groups had similar renal function, daily urinary excretion of sodium and doses of steroids. The natriuretic response to saline was not affected in hypertensive transplants and changes in blood pressure, renin and aldosterone were identical in both groups. Similar correlations between pre-saline fractional excretion of sodium (FENa+) and the FENa+ obtained during saline were obtained in normotensive and hypertensive patients. These results demonstrate that in renal transplant recipients of young donors no exaggeration of the response to saline occurs in hypertensive subjects thus suggesting that normal kidneys may carry their characteristics when transplanted in a new environment. The role of renal denervation remains unclear.

Adult↗
PubMed1983

Permanent loss of ultrafiltration capacity of the peritoneum in long-term peritoneal dialysis: an epidemiological study.

Permanent loss of the ultrafiltration (UF) capacity of the peritoneum has been observed with an increasing frequency among our patients treated by long-term intermittent (IPD) and/or continuous ambulatory peritoneal dialysis (CAPD). The analysis of various characteristics of our PD population (patients age, dialysis techniques, peritoneal infection rate and treatment duration) indicates that the incidence of this complication increases exponentially with the duration of PD, the loss of UF capacity being observed after a shorter period in CAPD than in IPD. These observations suggest that long-term irrigation of the peritoneal cavity leads to a progressive deterioration of the peritoneum resulting in its altered permeability with loss of the ability to ultrafiltrate; the cause of this abnormality is as yet unknown.

Adult↗
PubMed1983

[Carpal tunnel syndrome in chronic hemodialysis patients. An etiopathogenetic approach. Apropos of 31 surgically-treated cases].

Thirty-one carpal tunnel syndromes were seen in 20 patients treated by haemodialysis for renal failure. At the time of operation, the duration of the haemodialysis was an average of 9 years. On 24 occasions, the syndrome existed in the limb of the arterio venous fistula but on 7 occasions it only appeared in the opposite limb. The syndrome is characterised by the development of, or the worsening of paraesthesiae during haemodialysis sessions. The degree and duration of the numbness in the fingers in the morning was particularly striking. At surgery, the nerve was always obviously narrowed. It was noted in 21 cases that there were greyish granulation in the synovium and sometimes intra tendinous nodules. All the operated cases improved. The pathogenesis is discussed in relation to amyloid deposits. The haemodynamic role of the fistula seems to be to make the development of the lesion more likely. Microscopic examination and biochemical studies give rise to the conclusion that this is an AL type of amyloidosis.

Adult↗
PubMed1983

[Hypoxemia in hemodialysis: hemodynamic mechanism? Hemodynamic and spirometric study using acetate and bicarbonate buffers].

The background of this study is the occurrence during acetate hemodialysis (HDA) of arterial hypoxemia associated with well described vasodilatator hemodynamic changes. Our aim was to evaluate the relationship between these 2 phenomena. Eleven patients (7 males, 4 females, mean age 54 years) were compared in a protocol of HDA and bicarbonate hemodialysis (HDB) as regards their cardiac output measured by the dye dilution method, blood gases and respiratory gas measurements made at the bedside. The results show significant hypoxemia with hypocapnia as soon as the 30th minute of HDA and no significant variation of cardiac index. No significant variation of respiratory response was noted. Arterial prostaglandin levels rose significantly higher during HDA (+ 302%) than HDB (+ 163%; 2 alpha less than 0,05). The absence of a correlation between arterial hypoxemia and hemodynamic changes in HDA compared to HDB suggests that the phenomena are not interdependent. The importance of increased thromboxane activation in HDA will require further investigation.

Acetates↗
PubMed1982

[Immunologic selection of donors and recipients in renal graft: transplantation antigens ].

For the immunologic selection of donors and recipients in renal transplantation, several antigens must be considered: ABO and Lewis antigens identified by red cell typing, HLA-A, HLA-B and HLA-DR antigens identified by leucocyte typing and HLA-D antigens explored by mixed lymphocyte reaction (MLR). In renal grafts with living related donor, the best donor is ABO compatible, HLA-A and B identical, MLR negative with the recipient. In renal grafts with cadaver donor, the best recipient is ABO and Lewis compatible and must present the greatest number of HLA-A, B and DR identities with the donor. The number of cadaver donors is relatively small and the selected recipient does not however present a good HLA compatibility with his donor.

Blood Grouping and Crossmatching↗
PubMed1981

Middle molecule accumulation in uremia: an "extra uremic factor".

To evaluate middle molecule (MM) accumulation in relation with patients' well-being, plasma MM were analyzed in 115 uremic patients by using the two-step chromatographic technique described by Fürst et al. Unexpectedly, most of the patients exhibited small or undetectable subpeaks 7a, 7b, 7c, 7d. However, patients on regular dialysis treatment tend to present higher MM concentrations when a complication, such as infection, hyperparathyroidism, symptomatic neuropathy, or intercurrent disease occurs and peak 7d was very prominent after radio-contrast media administration. No correlation was found between plasma MM and small molecule accumulation (urea, creatinine, and uric acid) or residual renal function or hematocrit. An unexpected correlation was found between some MM fractions and serum PTH. These results indicate that MM do not accumulate in plasma only as a result of impaired renal function. This suggests considerable variations in their generation rates may be due to unknown misleading artifacts, PTH breakdown products, or other factors.

Adolescent↗