Search PubMed⌕ Search

Biomedical subjects

C Mills

Publications and source records attributed to C Mills.

At least 73 records · Page 4Linked to original sources
PubMed1987

The postphlebitic syndrome following shaft fractures of the leg. A significant late complication.

Sixty patients each of whom had a fracture of the lower limb a minimum of five years (median 11 years) previously were studied by photoplethysmography, foot volumetry, popliteal venous reflux and arterial Doppler measurements. The non-fractured limb was used as a control. Postphlebitic symptoms were present in 51% and signs in 49% of fractured limbs compared with 4% and 24% respectively in the control limbs. The incidence was greater in patients who had fractured 15 years or more previously than in those who had fractured 5 to 15 years previously. Eleven limbs had clinically disabling postphlebitic symptoms including venous ulceration. The postphlebitic syndrome following lower limb fractures in young patients is more common than generally appreciated and develops after a prolonged latent interval. A prospective randomised study using prophylactic anticoagulation for lower limb shaft fractures may be justified.

Adolescent↗
PubMed1987

The effects of felodipine on left ventricular function in beta-blocked patients.

Felodipine is a dihydropyridine calcium antagonist which has a positive inotropic effect in the dog in vivo. However to date, no inotropic effects have been described in man. Thus, the solvent for the intravenous administration of the drug was infused, followed by the active solution, in 9 beta-blocked patients undergoing coronary angiography; heart rate was held constant by atrial pacing. Haemodynamic variables were measured with the Mills combined left ventricular catheter-tip manometer and aortic electromagnetic blood velocity transducer. In all patients, peripheral vasodilatation was observed. In 8 patients, this was accompanied by a 9 to 50% increase in maximum rate of rise of left ventricular pressure indicating a small positive inotropic effect.

Adrenergic beta-Antagonists↗
PubMed1986

Iodinated cholylglycyltyrosine: a new agent for hepatobiliary imaging.

The characteristics of radiolabelled cholylglycyltyrosine (CGT), a recently synthesised bile acid, were studied. 125I-CGT-Na was found to have a short plasma half-life of 1.6 +/- 0.4 min in rats and 3.1 +/- 0.7 min in dogs. Biliary clearance studies showed the cumulative biliary output of the tracer over 20 min in rats to be 95.7% of the total dose administered, with a mean biliary transit time (50% retention time) of 4.0 +/- 0.1 min, i.e. similar to the biliary kinetics of taurocholate. 131I-CGT-Na proved to be satisfactory for hepatobiliary imaging in rats and dogs at doses of 35 microCi (1.3 MBq) in rats and 90 microCi (3.3 MBq) in dogs. Satisfactory hepatic images were also obtained in rats that had high bilirubin levels produced by obstruction or the recycling of bile. These results show that CGT has better pharmacokinetics than currently used hepatobiliary imaging agents, and that this new compound may be useful in scintigraphy even in the presence of jaundice.

Animals↗
PubMed1985

A new method of complete biliary retention.

We describe a new modified method of producing non-obstructive complete internal biliary retention in the rat by draining bile into the caudal vena cava. This relatively simple method has the additional advantage that restraining cages are not necessary.

Animals↗
PubMed1984

Sorbitol dehydrogenase is a zinc enzyme.

Evidence is given that tetrameric sorbitol dehydrogenase from sheep liver contains one zinc atom per subunit, most probably located at the active site, and no other specifically bound zinc or iron atom. In alcohol dehydrogenases that are structurally related to sorbitol dehydrogenase, more than one zinc atom per subunit can complicate investigations of zinc atom function. Therefore, sorbitol dehydrogenase will be particularly valuable for defining the precise roles of zinc in alcohol and polyol dehydrogenases, and for establishing correlations of structure and function with other important zinc-containing proteins.

Alcohol Oxidoreductases↗
PubMed1983

Nuclear magnetic resonance imaging in multiple sclerosis.

Ten patients with definite multiple sclerosis underwent hydrogen nuclear magnetic resonance imaging with a 3.5 kilogauss superconducting magnet, using the inversion recovery and spin-echo techniques of signal acquisition. Results were compared with high-resolution x-ray computed tomography. Spin-echo images demonstrated abnormal regions as areas of variably increased signal intensity. The contrast between abnormal and normal white matter improved as the intervals between sequential radiofrequency pulses and between pulse administration and signal sampling were increased. Inversion recovery images demonstrated abnormal areas as regions of decreased signal intensity but did not visualize lesions as well as spin-echo imaging. Spin-echo and inversion recovery imaging each demonstrated more extensive abnormalities than did computed tomography.

Adult↗
PubMed1983

Carcinoma of the ureter: natural history, management and 5-year survival.

We reviewed retrospectively 53 new cases of primary ureteral carcinoma. Each patient was staged pathologically and survival by operative procedure was compared. Depth of tumor invasion is the most accurate indicator of over-all outcome. Patients with stage A tumors had an 80 per cent 5-year survival rate, compared to only 33.3 per cent of the patients with stage C lesions. Patients also were divided into 2 groups: group 1 patients had a ureteral lesion only, and group 2 patients had a ureteral tumor and a second primary urothelial lesion. No difference was found in 5-year survival rates for patients in groups 1 (48.3 per cent) and 2 (47.7 per cent). Since prognosis for patients with low stage tumors was not enhanced by an aggressive operation a more conservative approach is indicated.

Carcinoma↗
PubMed1983

Interpretation of the effects of propranolol on coronary reactive hyperaemia.

The effect of propranolol on the hyperaemic response after transient coronary arterial occlusion has been evaluated. The excess volume of blood delivered to the myocardium after an occlusion is diminished after propranolol in proportion to the reduced coronary blood flow. From the findings it is not necessary to postulate a change in the intrinsic mechanisms of reactive hyperaemia after propranolol has been given.

Animals↗
PubMed1982

The value of neuroradiology in infantile spasms.

The results of neuroradiologic studies of 71 children with infantile spasms treated with ACTH were correlated with the developmental outcome at follow-up (mean 62 months, range 14 to 207 months). Fifty-two (73%) patients had an abnormal NRS on initial evaluation; 49% had cerebral atrophy, 18% had congenital anomalies, and 6% had hydrocephalus. Twenty patients were normal on initial clinical evaluation. At follow-up only the eight (40%) with normal NRS were normal. Twelve (60%) who had unexpected abnormalities on NRS were retarded at follow-up. CAT scanning is necessary to predict the developmental outcome in developmentally normal children with infantile spasm. Eight of nine patients with normal NRS in the early treatment group were developmentally normal at presentation and follow-up. Ten patients who were developmentally normal before spasms began, and had normal NRS but were in the late treatment group, were retarded at initial evaluation and follow-up. This finding suggests that early treatment of children who have a normal NRS and normal development at onset of spasm prevents mental retardation.

Adrenocorticotropic Hormone↗
PubMed1982

Effect of heart rate and stroke volume on gas mixing in dog lung.

In nine anesthetized and ventilated dogs heart block was induced at thoracotomy, a pacemaker was inserted, and an electromagnetic flow transducer was placed round the main pulmonary artery. The chest was then closed. Stroke volume (SV) was varied by changing central blood volume. Ventilatory dead space (VDS) and alveolar nitrogen mixing efficiency (ANME) were measured at three levels of heart rate (HR) and three levels of SV independently varied during life and also after cessation of heartbeat. Neither VDS nor ANME showed a significant change with HR or SV during life, but mean VDS increased by 43 ml (22%) and mean ANME decreased by 4.4% postmortem. We conclude that cardiac action increases gas mixing at the interface between inspired and resident gas but has only a small effect on gas mixing distal to the interface during respiration without breath holding.

Animals↗
PubMed1981

An analysis of different techniques for distal hypospadias repair: the price of perfection.

We discuss the risks of total surgical correction of distal hypospadias with chordee, review 42 such cases and analyze 4 common surgical procedures that were used. The over-all complication rate was 16.6 per cent (7 of 42), with 9.5 per cent (4 of 42) of the cases requiring addition urethral reconstruction. All complications occurred following procedures designed to extend the urethral meatus to the tip of the glans (Horton-Devine 5 of 15 and Ombrédanne 2 of 8). In contrast, no complications occurred following urethral advancement or Allen-Spence repairs (0 of 19). The physician and family should be aware of the increased risk attendant with total anatomical urethral correction in contrast to less extensive surgery, which gives an excellent functional result with minimal risk.

Adolescent↗