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Biomedical subjects

C Milan

Publications and source records attributed to C Milan.

95 records · Page 6Linked to original sources
PubMedDate not supplied

[Markers of the hepatitis B virus and chronic alcoholism. Prevalence and risk factors].

In this retrospective study, the prevalence of hepatitis B virus markers was studied in groups of heavy drinkers and primary hepatocellular carcinoma patients (202 patients), hospitalized for the first time in a medical department of gastroenterology in France. HBs Ag, anti-HBs and anti-HBc were respectively detected in 1.1, 25.8 and 20.9 p. cent of alcoholic patients without hepatocellular carcinoma. The overall prevalence of hepatitis B virus infection was 26.9 p. cent. The presence of hepatitis B virus markers did not depend on excess alcohol consumption, sex, age, alcoholic liver disease intensity, or previous gastrointestinal bleeding or hospitalization, but was related to racial group and residence in countries with a high prevalence of HBs Ag. HBs Ag, anti-HBs and anti-HBc were observed in 0, 36.4 and 36.4 p. cent of the alcoholic cirrhotic patients with hepatocellular carcinoma and the prevalence of hepatitis B virus markers was 45.5 p. cent. The findings reported in this study suggest that hepatitis B virus infection has no major role in determining the rate of progression of alcoholic liver disease and plays a far lesser causal role in hepatocellular carcinoma in France than in high incidence regions.

Alcohol Drinking↗
PubMedDate not supplied

[Rectocolonic cancers in young patients. A population study (Côte-d'Or: 1976-1983].

Between 1976 and 1983, 1,783 colorectal cancers were diagnosed among the Cote-d'Or residents; of these 44 (2.5 p. 100) were under age 45. Cancer developed more often on familial polyposis (11.4 p. 100), ulcerative colitis (2.3 p. 100) or in the Lynch cancer family syndrome (4.6 p. 100) before 45 than in older patients: 0.2 p. 100 (p less than 0.01), 0.2 p. 100 (NS) and 0 p. 100 (p less than 0.01) respectively. There was no significant difference between young and older patients concerning the site, the histologic type or the stage of diagnosis. Curative resection rates were similar before age 45 (68.2 p. 100) as after that age (61.8 p. 100). Operative mortality was lower in younger (3.3 p. 100) than in older patients (12.6 p. 100; NS). After surgery for cure (operative mortality excluded) the 5-year corrected survival rates were similar in the two age groups: 69.4 +/- 8.8 p. 100 and 64.0 +/- 1.8 p. 100 respectively (NS). These data suggest that with the exception of predisposing diseases there is no important difference between young and older patients with regard to the anatomoclinical and evolutive aspects of colorectal cancers.

Adolescent↗