Search PubMed⌕ Search

Biomedical subjects

C Mietens

Publications and source records attributed to C Mietens.

At least 37 records · Page 2Linked to original sources
PubMed1978

[Serum-concentrations of the immunoglobulins iga, ige and igm in children with different age and diseases with different aetiologies (author's transl)].

Normal values of the immunoglobulins, G, A and M in the serum were measured with the immunodiffusion-method by Mancini et al., (1965) (immunodiffusion-plates: Hyland-Travenol) for children in the age between 0-15 years. Moreover, we measured the course of the immunoglobulin development of some babies during hospitalisation. Here we found a wide individual range in synthesis of immunoglobulins.

Adolescent↗
PubMed1977

[The role of inter-alpha-trypsin-inhibitor (concentration of serum of childhood) (author's transl)].

The feeble monovalent, humoral protease inhibitor inter-alpha-trypsin inhibitor has to be regarded as inhibitogen for different secretory, low-molecular, polyvalent inhibitors. Kallikreine acts as inhibitor-releasing enzyme. The inhibitor levels in the serum were determined for children of different ages. Contrary to adult patients not showing a lack of inhibitogen as consequence of the disease, inhibitogen insufficiencies are rather frequent, particularly for prematures and newborns with respiratory distress and inflammatory diseases. Obviously, in early childhood the production of inhibitogen is not yet in full progress. In case of increased inhibitor consumption or excessive kallikrein consumption this condition results in an inhibitogen insufficiency.

Adolescent↗
PubMed1977

[Immunglobulin concentrations in cerebrospinal fluid of children. Studies regarding age dependency and changes during inflammatory disease of CNS (author's transl)].

75 children of different age groups were examined for immunglobulin concentrations in spinal fluid. No statistical significant differences were found between the age groups a) 1 month to 1 year, b) 1 year to 5 years and c) 5 years to 12 years. The average level for IgG was 1,41 +/- 0,8 mg%, for total protein 34,8 +/- 9,6 mg%. IgA and IgM were detectable not or only in small quantities even when the spinal fluid was concentrated. Furthermore 21 children with viral and 9 with purulent meningitis and 2 with encephalitis were examined. Patients with meningitis had a distinct increase in IgG, IgA and IgM. The increase was more pronounced in purulent than in viral meningitis. Children with encephalitis had an increase of IgG and in one case an increase of IgA. Continous examination of immunglobulins in spinal fluid from a child with inoperable hydrocephalus revealed a steady increase of all 3 immunglobulins which was probably a result of elevated vascular permeability.

Age Factors↗
PubMed1976

[Arteritis of the large vessels originating at the aorta (Takayasu arteritis) in childhood (author's transl)].

A 9-month-old female child with extensive inflammatory lesions in the large arterial trunks originating at the aorta (Takayasu arteritis) was reported. Severe cerebral, intestinal and coronary circulatory disturbances as well as insufficient blood supply in both arms, particularly the left arm, developed as a result of the stenoses and obliterations. Clinical course, postmortem findings and the results of EKG, EEG and carotid angiography were discussed. The onset in infancy and the very rapid progression of the disease were unusual.

Aortic Arch Syndromes↗
PubMed1976

[Numerical and structural anomalies of chromosome no. 18 (author's transl)].

Two newborn babies with trisomy 18 and one with a deletion of the short arm of chromosome 18 (Syndrome 18p-) were admitted within 3 months to the Westfälische Landeskinderklinik Bochum. Under this aspect the clinical appearance of numerical and structural anomalies of chromosome 18 is described. Clinical symptomatiology which is rather typical for Trisomy 18 (Edwards syndrome) so that a diagnosis may be made in many instances even before the result of chromosomal analysis is available is compared with the facts given in the literature. The 83 cases of syndrome 18p- published so far are presented in a table. The absolute frequency compared with conceptional age of the mother gives a 2 peak distribution curve with one maximum between 25 and 29 years and one between 40 and 45 years. Similar patterns indicating two different ways of pathogenesis were described for trisomy 18 and 21. Furthermore patients suffering from syndrome 18p- show an increased incidence of IgA deficiency, which is 1:2 compared to 1:500 to 1:700 in an unselected population.

Abnormalities, Multiple↗
PubMed1975

[Antibody deficiency states in children].

In more than 2500 immunoelectrophoreses and quantitative immunoglobulin determinations 19 cases of transitory hypogammaglobulinaemia, two cases of sex-linked congenital agammaglobulinaemia, six cases of selective IgA deficiency and nine cases of dysgammaglobulinaemia were diagnosed. In congenital agammaglobulinaemia life-long substitution with gammaglobulin must be instituted. Transitory hypogammaglobulinaemia which occurs mostly at the beginning of the second trimenon usually regresses spontaneously at the age of 15 to 18 months. The increased susceptibility to infections can be overcome by gammaglobulin administration. Dysgammaglobulinaemias with serum concentrations below 400 mg/dl also require gammaglobulin supplements. In IgA deficiency the greatest possible care as regards substitution is indicated because of the danger of severe anaphylactic reactions.

Agammaglobulinemia↗
PubMed1975

Diagnosis and therapy of renal tubular acidosis in infancy.

While distrubances of the acid-base balance are frequently seen in infancy, renal tubular acidosis is a rather rare disease but should be considered as differential diagnosis if metabolic acidosis persists after adequate treatment. Proximal and distal tubular acidosis with primary and secondary forms can be differentiated. Proximal RTA is characterized by the loss of bicarbonate, distal RTA by a defect to establish a hydrogen ion gradient and thus to accomplish acidification of urine. In addition to these two basic forms a bicarbonate wasting state in distal RTA has been described. A patient with these clinical features is presented. He was admitted to our hospital at the age of 1 month with meningitis, enteritis and marked dystrophy. A persistant hyperchloraemic acidosis with concomitant hypokalaemia was present. The ammonium chloride loading test confirmed the diagnosis of primary distal RTA. Renal biopsy performed with 1 year of age revealed nephrocalcinosis of the inner medullary region of the kidney while the cortex was not affected. The patient first needed alkali doses of 12 mEq/kg/day which could be gradually reduced to 3.5 mEq/kg/day. Under additional potassium substitution of 5 mEq/kg/day he was thriving well. Differential diagnosis and the particular clinical features of this case are discussed.

Acidosis, Renal Tubular↗
PubMed1975

[Quantitative changes of serum immunglobulins during infectous diseases in childhood (author's transl)].

Immunelektrophoreses and quantitative determinations of serum immunglobulins were performed for 298 children with infections of the upper and lower respiratory tract, chronic and recurrent infections, pyelonephritis and Salmonella infections. Minor changes were seen for IgG, 80% of the patients had levels within the normal range. Many patients, however had increased levels of IgA and IgM, while a decrease of these immunglobulins below the normal range were rarely detected. Children with upper respiratory tract infections had increased IgA in 28 per cent and increased IgM in 44 per cent, those with bronchitis in 21 per cent an IgA and in 45 an IgM increase. Most frequently immunglobulin elevations were seen in patients with pneumonia: IgA was in 50% and IgM in 67% increased above the normal range. Patients with recurrent infections had an IgA elevation in 34% and an IgM increase in 33%. 35% of children with pyelonephritis had an IgA and IgM increase. Children suffering from Salmonella infections had an increased IgA in 29 and IgM in 67%. The result of other authors and of factors leading to an elevation of serum immunglobulins are discussed.

Bacterial Infections↗
PubMed1975

[Virus infections of the respiratory tract in childhood (author's transl)].

Comprehensive epidemiological studies revealed that every individual is suffering from a respiratory tract infection in the average 6 times a year. 97% of these are caused by viruses. Identical clinical symptoms may be produced by many different agents, thus the etiology of an illness can only be identified by virus isolation and serological tests. The frequency of isolations is varying in adults and in children as well as in ambulatory and in hospitalized patients. The persistently observed susceptibility for new infections is caused by the great variety of possible etiologic agents especially in upper respiratory infections and the peculiarities of local immunity in the respiratory tract. An influence of chilling could not be demonstrated scientifically in spite of controverse clinical observations. It was proved however that allergic individuals succumb more frequently to viral infections. Overweight in infancy increases susceptibility for bronchitis and bronchiolitis. Superinfections by bacteriae are not rarely complications of viral diseases and antibiotic therapy may become necessary eventually. Leucocytosis and an elevated erythrocyte sedimentation rate are only criteria of limited value to distinguish viral and bacterial infections. Specific virostatic therapy is not possible so far for respiratory tract illnesses, but for prophylaxis of infections with influenza A2 amantadine-HCl may be used. Gammaglobulin has a prophylactic effect as well for certain virus infections but is of little use for antiviral therapy.

Adenoviridae↗
PubMed1973

[Celiac disease].

Explore the source record for details and available documents.

Celiac Disease↗