Search PubMed⌕ Search

Biomedical subjects

C Micheau

Publications and source records attributed to C Micheau.

125 records · Page 7Linked to original sources
PubMedDate not supplied

[Anatomo-pathology and attempt at classification of epitheliomas of the nasopharynx].

Lympho-epithelioma is a tumor of the nasopharynx and tonsillar region. From the first description of Regaud and Schmincke in 1921, the concept of this tumor changed in some ways and, up to now, the characteristic of lympho-epithelioma varied according to observers, resulting in a very confusing situation : some of pathologists consider lympho-epithelioma as a subtype of squamous cell carcinoma, others, as a true entity to be preserved; this last opinion is based upon epidemiologic and clinico-radiologic features sufficiently distinctive to justify separation into a tumor entity. The author suggests in this paper a new classification of nasopharynx carcinomas and emphazises diagnosis difficulties of lympho-epithelioma.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

[Carcinoma of the nasopharynx (cavum) : clinical and developmental aspects].

Between 1959 and 1974, two hundred and ninety six carcinomas of the nasopharynx were seen at the Institut Gustave-Roussy, in adults. 78% were in man. The most frequently encountered were undifferentiated or poorly differentiated forms, 76% of cases. 38% only of the patients had their birthplace in France. On the first examination 36% of the cases had a T4 tumour, 50% had fixed cervical lymph nodes and 77% had distant metastases. 30% of the cases could not be treated following a protocol attempting complete cure. Since 1970 the Iridium method of irradiation is not used in T1 and T2 cases and all were treated by high voltage methods with eventual complementary surgical treatment for persistent nodes. The survival rate at 5 years is 30% for the whole group and 37% for the determinated group. Failures were encountered by local recurrence present in 58% of those dying of the disease and distant metastases were found in 37%. 20% of the patients died from distant metastases without local and regional lymph node recurrences. Unfavourable prognostic factors are initial involvement in bone and the differentiated histological type. It was noteworthy that associated multiple cancers were rare.

Adolescent↗
PubMedDate not supplied

[Scleroma of the upper respiratory tract. Apropos of a case of laryngeal localization].

A case of rhinoscleroma with laryngeal localization is reported. Geographic distribution of this granulomatous disease is discussed. Clinical and paraclinical features are explained. Its tumor-like appearance and local spread arouses suspicion of malignancy but differential diagnosis also includes fungal infections and numerous granulomatous diseases. The classic histopathology consists of large Mikulicz's cells. Treatment is essentially based upon antibiotics.

Adult↗
PubMedDate not supplied

[A specific histological marker of undifferentiated carcinoma of the nasopharynx. The ACIF (Anti-Complement Immunofluorescence) test].

The relationship between E.B.V. infection and nasopharyngeal carcinomas can be used as a marker of these tumors (A.C.I.F. test). The method reveals the nuclear antigen (E.B.N.A.) by anti complement immunofluorescence. It was applied to 102 patients with N.P.C. and was found positive only in undifferentiated carcinoma (U.C.N.T.). This "marker" can be useful in search of primary from lymph node metastasis.

Antigens, Viral↗
PubMedDate not supplied

[Primary malignant cutaneous lymphomas excluding mycosis fungoides. Anatomoclinical study of 16 cases].

Cutaneous primary lymphomas excluding mycosis fungoides and Sezary Syndrome represent a rare condition. Few papers are published on the subject. The authors report a retrospective study of 16 cases concerning only these primary lymphomas. It comprises 10 adults and 6 children. In 13 cases the cutaneous tumor was solitary without extra-cutaneous lesion, in 3 cases there was a satellite simultaneous lymph node. The most frequent location was head and neck region (7 cases with 4 cases from children); limbs were concerned too (5 cases/16); more rarely trunk. Our cases were classified with reference to lennert's classification. We found that large cells lymphomas were predominant: centroblastic (4 cases), lymphoblastic (4 cases), immunoblastic lymphomas (6 cases). The clinical course was unfavourable in 50% of our cases in less than 3 years: 6 lethal cases, and 2 metastatic disseminations. These 8 cases belonged to the pejorative group of lymphomas (large cells type). The 2 cases with small cells population (centrocyto-centroblastic and lymphoplasmocytoïd type) were free of disease for 5 and 2 years after diagnosis. Thus, our experience suggests that there is a relations hip between the histologic type of cutaneous lymphoma and the course of the disease. In disseminated cases, the extra-cutaneous extension was located in lymph nodes, bone marrow, as it was mentioned in literature.

Adult↗