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Biomedical subjects

C Micheau

Publications and source records attributed to C Micheau.

At least 73 records · Page 4Linked to original sources
PubMed1982

Lymphoid cells in lymph nodes and peripheral blood of patients with squamous cell carcinoma of the head and neck.

Fifty-five patients with squamous cell carcinoma of the head and neck were evaluated immunologically by measuring the level of T cells (E-RFC) and high affinity subset T cells (E-29) in the peripheral blood and peritumorous lymph nodes. A significant decrease (p less than 0.05) in mean percentage of E-29 was observed in cancer patient peripheral blood. In peritumorous lymph nodes, there was no difference in terms of total T cells or of high affinity subset T cells, as compared to non-malignant lymph nodes, or between tumor-free and metastatic lymph nodes. Macrophage content was much higher in metastatic than in tumor-free lymph nodes (p less than 0.05) and these macrophages frequently appeared to be more active when tested in phagocytosis of sheep red blood cells sensitized with IgG or IgM + C.

Acid Phosphatase↗
PubMed1981

A cytochemical and immunohistochemical approach to malignant histiocytosis.

Malignant histiocytosis (MH) is a true histiocytic disorder, whose identification is still based on too broad morphologic criteria. Using routine histology, cytochemical and immunohistochemical techniques on involved lymph nodes, 15 cases of MH have been investigated. Pleomorphism and cellular atypia, phagocytosis, lack of cohesiveness between proliferating cells, sinusoidal involvement, and plasmacytic infiltrate were the most common histologic features. MGG-stained imprints from 14 cases showed a composite tumor population mainly consisting of histiocyte-appearing cells, poorly differentiated atypical cells, and multinucleated giant cells. These cells, irrespective of cytologic features, revealed a diffuse, moderately to strongly positive reaction with acid phosphatase and nonspecific esterase. Naphthol-AS-D-chloroacetate esterase, Sudan black B, alkaline phosphatase, and beta-glucuronidase reactions were completely negative. Immunoperoxidase studies in 11 cases demonstrated that tumor cells stained positively for both kappa and lambda chains. These cells were also positive for albumin. Polytypic staining for IgG was observed in two cases, and a weak staining for lysozyme was found in two other nodes. Global results confirm the value of these studies for functional profile determination of MH proliferating cells. A combined approach using a variety of cytochemical and immunohistochemical techniques should be routinely considered in MH as useful additional studies for a more precise diagnostic definition of the disease.

Adolescent↗
PubMed1981

[Muco-epidermoid carcinoma of the mandible. A case report (author's transl)].

Muco-epidermoid tumours are reviewed, and a case of a muco-epidermoid carcinoma of the mandible in a 78-year-old man reported. Radiological examination suggested the presence of an ameloblastoma, but the scanner provided evidence of a possible malignant tumour. Diagnosis of a muco-epidermoid carcinoma was confirmed by pathological examination after hemimandibulectomy.

Aged↗
PubMed1980

Elective versus therapeutic radical neck dissection in epidermoid carcinoma of the oral cavity: results of a randomized clinical trial.

This study concerns 75 patients with squamous cell carcinoma of the oral cavity who were patients at the Gustave-Roussy Institute between December 1966 and July 1973. These patients were divided into two groups. The first group was comprised of 39 patients who underwent elective radical neck dissection; nodal involvement was present in 49% with capsular rupture in 13%. In the second group of 36, neck disease appeared during follow up in 19 cases. Therapeutic radical neck dissection was carried out in 17; the nodes were histologically positive in 15, 9 of which had a capsular rupture. In 2 cases, local or general conditions did not permit operative intervention. In this group, the involvement rate was 47% with a 25% capsular rupture rate. However, the comparison of the survival curves by the log-rank test did not reveal any differences, even though histologic prognostic factors were taken into account. These findings led to the conclusion that in squamous cell carcinoma of the oral cavity staged T1N0, T2N0, or T3N0 (from AJC's and UICC's clinical staging system), it seems possible, without risk, to delay neck dissection until a node is detectable, although it is reasonable to perform elective neck dissection in those cases in which the patient is unavailable for regular followup.

Carcinoma, Squamous Cell↗
PubMed1980

[Non-Hodgkin's malignant lymphoma: reliability of "typing" using cyto-enzymatic markers. Comparison with immunological markers (author's transl)].

Comparison between membrane markers and enzyme markers was made in 74 cases of non-Hodgkin's malignant lymphomas and a good correlation appears between both methods in order to distinct lymphomas into T and B origin. Enzyme markers are reliable and provide quickly made and easily interpretable documents. As far as T-lymphomas are concerned, three hydrolases namely acid phosphates e, acid esterase and B-glucuronidase give the same good results. As for B-lymphomas, a specific enzyme marker has to be found. Furthermore, typing of malignant lymphomas by enzymatic and/or immunologic methods appears to be quite better than from morphologic features such as convoluted or cleaved nuclei for example.

Acid Phosphatase↗
PubMed1980

[Carcinomas of the nasopharynx. Relationship between histological type and anti-Epstein-Barr virus serology (author's transl)].

This study was aimed at the comparison of values of anti-Epstein-Barr virus serology in different groups of patients suffering from carcinoma of the nasopharynx (NPC), classified according to histological type defined by the new classification of the WHO. A group of patients with other tumours of the upper respiratory and digestive tract was used as a control. Antibody levels were high in patients with undifferentiated carcinomas whilst they were low in the controls. In patients with differentiated carcinomas antibody levels were most often equivalent to those of the controls, even though high values were sometimes seen. These findings would appear to offer evidence that the new histological classification of NPC is well founded, and to a certain extent reflect the epidemiological, clinical and therapeutic classifications already seen for these two types of carcinoma.

Animals↗
PubMed1980

Pseudotumoural fibrous dysplasia of the maxilla: radiological studies and computed tomography contribution.

Clinical, radiological, and histological problems arise relating to fibrous dysplasia of the maxilla. Clinically, 11 of our 39 cases developed so rapidly that the lesions were suspected of being malignant. The histological diagnosis may be very difficult, since any tumoural, reactive, or healing process may simulate fibrous dysplasia. As a general rule, the diagnosis is established most easily by the radiological examination. The radiologist's responsibility is important, as mistakes may have serious consequences. We report four pseudotumoural forms of maxillary sinus fibrous dysplasia. All were characterised clinically by rapid evolution, radiologically by opacity of the sinus with apparent destruction of its wall, and histologically by difficulty in establishing the diagnosis. In two cases indeed, the initial histological interpretation was an osteogenic sarcoma. Due to its excellent densitometric resolution, computed tomography provides an invaluable contribution by displaying the fibrous wall of an intact or even thickened maxillary sinus when conventional radiology has suggested a destructive process. In difficult cases of maxillary fibrous dysplasia, computed tomography should be used as a supplementary investigation to establish the correct diagnosis.

Adult↗
PubMed1980

[Intra-arterial chemotherapy for the treatment of tumors of the nasal sinuses. Results in 50 cases (author's transl)].

Fifty patients with primary epidermoid carcinomas of the nasal sinuses were treated by intra-arterial chemotherapy, alone (2 fatal iatrogenic accidents occurred) or in association with surgery and/or radiotherapy (48 cases). Adverse reactions due to chemotherapy were noted in 11 patients (22%), and two of these were fatal (4%). In eleven patients (22%) the initial curative chemotherapy was unsuccessful and all died after a mean survival period of 12 months. Local recurrence was observed in 7 patients (14%), the mean survival period being 11,5 months, and in 6 patients (12%) with local glandular involvement the mean period was 15 months. Identical survival rates of 57% after 3 years (8/14) and 50% after 5 years (6/12) were observed in 14 cases with endosinusal forms and 14 patients in whom the infrastructures were treated. In 22 patients there was exteriorization of the lesion, and the survival rate was 31% after 3 years (7/22) and 15% after 5 years (3/19). All 7 patients with pterygomaxillary lesions died within 3 years. Overall results in the 50 patients treated show that: -- 23/50 (46%) survived for 3 years -- 15/43 (35%) for 5 years -- 5/19 (26%) for 10 years.

Adult↗
PubMed1980

[Tuberculosis of the mucosa of the naso-pharynx. A clinical study of 37 cases seen at the Gustave-Roussy Institute between 1961 and 1978 (author's transl)].

The authors report a series of 37 cases presenting with tuberculosis of the mucosa of the upper naso-pharynx. The localization broke down as: 5 cases of tuberculosis of naso-sinuses, 6 of the buccal cavity, 3 of the cavum, 10 of the oro-pharynx, 1 of the hypopharynx, and 12 of the larynx. -- The male-female ratio was unequal (2:1 M:F) -- The mean age was 52.5 years -- Most patients were European. The 3 rhinopharyngeal cases were in North Africans. -- Macroscopically the lesions were of a malignant character in 70%. -- There was palpable lymphadenopathy in 56% of patients. The most commonly involved chain was the jugulo-carotid, especially the subdigastric group. -- There was tuberculosis in the entourage in 20/37 cases. CXR was normal in 17 cases. On hospitalisation active T.b. was discovered in 15 cases. -- Biopsy confirmed a definitive diagnosis in every case. -- All patients were treated medically. There were no cases of resistant organisms. The results were excellent.

Adolescent↗
PubMed1979

Lymphoepitheliomas of the larynx (undifferentiated carcinomas of nasopharyngeal type).

Three cases of lymphoepitheliomas of the larynx are reported. This type of carcinoma--which occurs almost exclusively in nasopharynx--is very unfrequent in the larynx (0.2%). In the 3 cases, the tumors arose in a ventricular diverticulum which presented the same lymphoepithelial structure as the tonsils. Under such conditions, these lymphoepitheliomas, which have to be called 'undifferentiated carcinomas of nasopharyngeal type' are believed to develop from the lymphoepithelial tissue of the laryngocele.

Adult↗
PubMed1979

Infantile olfactory neuroblastoma. A clinicopathological study with review of the literature.

A case of olfactory neuroblastoma occurring in a 3-year-old girl is reported. The rarity of the lesion in early childhood is stressed and discussed with the clinico-pathological characteristics of the tumour, which are apparently more aggressive the younger the patient. Olfactory neuroblastoma should be considered as a possible diagnosis regardless of the age of the patient.

Child, Preschool↗
PubMed1979

Subsets of malignant lymphomas in children related to the cell phenotype.

We studied the lymphomatous cells of 39 children presenting with the classical features of malignant lymphoma. Twenty-two had T lymphoblasts. We could classify these patients into three subsets: The T lymphoblasts from children group 1 displayed antigen(s) shared by a thymocyte subpopulation, had terminal deoxynucleotidyl transferase (TDT), but no affinity for peanut agglutinin (PNA). The T lymphoblasts from children group 2 lacked the thymocyte antigen(s), had no TDT, but showed affinity for PNA. The T lymphoblasts from children group 3 displayed mature T-cell antigens, had no TDT, and no affinity for PNA. Children from the three groups were similar in terms of clinical presentation, age and sex distribution, and cell morphology; however patients from the three groups might have a different prognosis. Fourteen children had B lymphoblasts that, in half of the cases, had affinity for Helix pomatia agglutinin. Three patients had lymphoblasts lacking specific marker. Two of them had cells displaying an antigen found on common acute lymphoblastic leukemia cells and had TDT.

Adolescent↗
PubMed1978

Proposal for a new histopathological classification of the carcinomas of the nasopharynx.

A new classification scheme for malignant tumors of the nasopharynx is proposed in which the undifferentiated carcinoma of nasopharyngeal types as a prominent position. This term replaces the previous obsolete term lymphoepithelioma on the basis of its clinicopathologic identity, its separation from squamous cell carcinoma, and its potential origin from anatomical areas other than the nasopharynx.

Carcinoma, Squamous Cell↗