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Biomedical subjects

C Meyers

Publications and source records attributed to C Meyers.

90 records · Page 5Linked to original sources
PubMedDate not supplied

D2 lymphadenectomy in the management of gastric cancer.

BACKGROUND: Gastric carcinoma is a significant cause of death in Ireland. Surgery offers the best option of cure, but the five-year survival following resection remains dismal at 10-15%. Experience from Japan and from some Western units suggest that an extended (D2) lymphadenectomy in association with gastrectomy increases the prospect of cure, but concern about the morbidity and mortality of this operation and lack of evidence from randomised studies has limited its acceptance. AIMS: This study reports the experience of a specialist upper gastrointestinal unit with D2 gastrectomy in a four-year audit. METHODS: Sixty-two resections were performed for gastric cancer. RESULTS: Nineteen patients were deemed unsuitable for the D2 procedure and underwent a more limited lymphadenectomy (D0 or D1). Forty-three patients underwent D2 resection, 12 with an oesophagogastrectomy, 22 with total gastrectomy and nine with a sub-total distal resection. Eight patients undergoing D2 resection had extended resections, five with splenectomy and three with a distal pancreatectomy. Post-operative complications occurred in 31% of patients. Thirty-day and 90-day mortality were zero. Median survival was 822 days in the D2 group (range 120-1,320). CONCLUSIONS: These results show that a D2 gastrectomy can be performed with a low morbidity and mortality and a median survival of greater than two years.

Adenocarcinoma↗
PubMedDate not supplied

Correlation of TGF beta 1 overexpression with down-regulation of proliferation-inducing molecules in HPV-11 transformed human tissue xenografts.

The epidemiologic association of human papillomavirus (HPV) infection with dysplasia and cervical cancer is well established. Transforming growth factor beta 1 (TGF beta 1) has regulatory effects on a broad spectrum of cell types and is a growth inhibitory protein for epithelial cells. To examine the phenotype of experimentally generated, HPV-11 transformed human tissues, we looked at expression of TGF beta 1 and a number of proliferation-enhancing molecules which are known to be regulated by TGF beta 1, including bcl-2, c-myc, c-Ha-ras, c-jun and NFkB. HPV-11 transformed xenografts showed up-regulation of TGF beta 1 expression and down-regulation of the expression levels of bcl-2, c-myc, c-Ha-ras, c-jun and NFkB. These results suggest that TGF beta 1 may exert antiproliferative effects on HPV-11 transformed papillomas by down-regulating different proliferation-enhancing molecules.

Base Sequence↗
PubMedDate not supplied

Transforming growth factor beta 1 (TGF beta 1) down-regulates expression and function of proliferation-inducing molecules in HPV-transformed cells.

The epidemiologic association of human papillomavirus (HPV) infection with dysplasia and cervical cancer is well established. Transforming growth factor beta 1 (TGF beta 1) is a growth inhibitory protein for epithelial cells. To examine the phenotype of HPV-transformed cells, we examined expression of TGF beta 1 and a number of cellular proliferation-enhancing molecules which are known to be regulated by TGF beta 1, including bcl-2, c-jun and NFkB. Previous studies had identified significant induction of TGF beta 1 and concomitant down-regulation of other growth stimulatory molecules in experimental papillomas. We used HPV-16 and -18 transformed cell lines. The HPV-16 transformed cells showed down-regulation of bcl-2 and NFkB as well as NFkB function upon TGF beta 1 treatment. The results suggest that TGF beta 1 may exert antiproliferative effects on some HPV-transformed cells by down-regulating expression and function of different proliferation-enhancing molecules. It is uncertain if this function is virus type specific and/or related to state of tumor cell progression.

Base Sequence↗
PubMedDate not supplied

Residential treatment: linkage with community drug treatment programs.

The realization that the program and services offered at the residential treatment center were not fully effective for some clients with multiple problems was an emotionally wrenching, but unavoidable, process. As the need for outside community substance-abuse referrals continues, it is important that ongoing relationships among agencies be established and nurtured. Dilemmas in creating these relationships have to be expected by all involved. Ways to resolve these problems must be put in place as quickly as they occur. Windows of opportunity to help residential treatment center clients with drug and alcohol problems must be recognized early on in treatment to ensure optimal services. Agencies must coordinate and cooperate with each other to be in position to seize these opportunities when they arise.

Adolescent↗
PubMedDate not supplied

[Cerebral atrophy, diagnosis using tomodensitometry compared with the new Wechsler intelligence scale in a psychiatric population].

In a psychiatric service, the present compares results of a simple psychometric test (in this case the new Wechsler Adult Intelligence Scale - WAIS) with those obtained from a brain CT Scan in two groups of 20 patients showing cerebral atrophy vs. twenty patients with normal CT Scan. Results show there exists a rather complex relationship between the cerebral atrophy scan and the intellectual deterioration. The performance to WAIS appears as globally lessened in cerebral atrophy cases. As for the cerebral rating scale, lower scores are registered only in vocabulary and similitudes in cerebral atrophy cases. Psychometric deterioration, according to scales and to formulation of "applicable" or "no-applicable" to age does not apply to the tests given in the course of the present study of cerebral atrophy.

Adult↗
PubMedDate not supplied

[Cerebral atrophy diagnosed by computer tomography compared with the "memory output profile" (MOP) in a psychiatric population].

The scope of the present study was a comparison between the profile of André Rey's mnesic rates and the results of CAT-scans for which were selected two groups of 20 patients, one of the groups suffering from brain atrophy and one presenting normal scans. The essential data derived from the present study is the practically complete lack of differences between both groups. Still, for the group suffering from brain atrophy slight variations appear in some sub-testing experiments in which memory only is not concerned but also the shape of simplified schemes to be reconstrued. It may thus be concluded that the notion of brain atrophy differs from the clinical concept of mnesic deterioration.

Atrophy↗
PubMedDate not supplied

[The role of the healer in neuropsychiatric care in the Revolutionary People's Republic of Guinea].

These comments reflect some actuality in Guinea, country where healers are generally controlled for their activities in order to integrate them to the medical life of the country, at least for primary care. In neuropsychiatry, the healer is more mysterious and less precise in its activities. He uses for its treatment exogenous factors: suggestion, a privileged relationship with his patient, drug administration. The endogenous factors used are dream utilisation, mystical states, transes. The neuropsychiatric healer integrates very poorly in the medical society and he will certainly create a problem in the future, with the coming of modern psychiatry. He will have to be situated in face of this socio cultural evaluation in the approach to mental patients. Nothing is done in this field, neither at the level of WHO, nor at the level of the state of Guinea.

Africa, Western↗
PubMedDate not supplied

[Télé-accueil: advantages and inadequacies of the tool. Viewpoint of the neuropsychiatrist].

The Royal law of july 20, 1973, clarified the mode of function of Tele-Accueil centers. They are at the border of neuropsychiatry. It looks like the psychiatrist is little concerned by this psychological help by telephone. Non paid listeners trained according to the Royal by law collect crisis telephone calls and try at most to face them. The reason for calling is for more than one third in socio-psychiatric problems. It should be welcome in the future, as wished by the Belgian State, that the psychiatric society gets concerned in the form of paramedical activity.

Adult↗
PubMedDate not supplied

[Cerebral atrophy, diagnosed by tomodensitometry, versus Rorschach organic psychosyndrome in a psychiatric population].

In a psychiatric service, this study compares results for the psycho-organic syndrome diagnosed with the Rorschach test to results from brain CT Scan in two groups (20 patients with cerebral atrophy and 20 patients with normal CT Scan). Our results are consistant with previous results mainly for patients with cerebral atrophy as demonstrated by neuro-radiological techniques. Significant differences appear in the discriminative value of isolated signs, a finding which should help in the future to establish a new classification of psycho-organic syndromes associated with cerebral atrophy.

Adult↗