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Biomedical subjects

C Metreweli

Publications and source records attributed to C Metreweli.

At least 253 records · Page 14Linked to original sources

Staging abdominal ultrasonography in nasopharyngeal carcinoma.

Abdominal ultrasonograms were performed on 81 unselected patients with newly-diagnosed nasopharyngeal carcinoma without clinical evidence of distant metastases. Two patients had ultrasonographic features suspicious of, but not diagnostic of, hepatic metastases. One of these two patients developed hepatic metastases six months after the examination while the other was free of metastases at follow-up 33 months afterwards. Of the 79 patients without evidence of metastases on ultrasonogram, two developed hepatic metastases after 22 and 32 months. Based on these results, we do not recommend abdominal ultrasonography as a routine staging investigation for nasopharyngeal carcinoma.

Carcinoma↗

Ultrasound in the diagnosis of the juxta-pleural lesion.

Any opacity on a chest radiograph has a wide differential diagnosis. Plain radiography and computed tomography may help to differentiate whether bone, intercostal soft tissue or mediastinum are involved. Bronchoscopy is often negative with peripheral lesions. This leaves the physician with a diagnostic problem. We examined ultrasonically 30 patients with juxta-pleural lesions and performed cutting biopsy in 27. Twenty-four of these produced positive histology (90%). The three that were not biopsied were anechoic and had pulsatile lesions due to vascular abnormalities. There were four benign lesions all with hypoechoic appearances and the 20 malignant cases showed a wide spectrum of echogenicity. Of the malignant lesions, 90% showed pleural line disruption with reduced respiratory movement suggesting chest wall invasion. There were no complications, despite using cutting biopsy.

Adolescent↗

Sonographic evaluation of the parotid ducts: its use in tumour localization.

The previously unreported sonographic anatomy of the intraglandular parotid ducts is described, and how this aids tumour localization is illustrated. Forty patients underwent ultrasonography and computed tomography (CT) sialography for the evaluation of parotid tumours. Ultrasound identified two extra unsuspected 5 mm tumours in the superficial lobe, which could not be seen at CT. Both techniques produced similar results for deep and mixed lobe lesions. Ultrasound had one false positive mixed lesion, which surgery subsequently found to be confined to the deep lobe. The full extent of invasion in three deep lobe tumours was revealed only by CT to be parotid invasion by nasopharyngeal carcinomas. We conclude that parotid sonography with reference to the intraglandular ducts is highly accurate in localizing parotid tumours and should probably be the first-line imaging technique. Computed tomography should only be necessary for visualization of deep lobe tumour extent and in those cases where the complete tumour boundary cannot be seen by ultrasound alone.

Humans↗

Sonographic diagnosis of portal vein invasion in patients with hepatocellular carcinoma: comparison with arterial portography.

The results of sonographic assessment of the main portal vein were compared with arterial portography in 65 patients with documented hepatocellular carcinoma. When compared with fully-diagnostic angiograms, obtained in 54 patients, sensitivity of ultrasound was 64% with a specificity of 98%. We conclude that ultrasound is a valuable first-line method of detecting portal vein invasion in the preoperative assessment of patients with hepatocellular carcinoma.

Adolescent↗

Ultrasound appearances of de Quervain's thyroiditis.

De Quervain's thyroiditis can be readily recognised by ultrasound. The sonographic features and previously unreported signs of two such cases are illustrated. One case had typical multiple hypoechogenic areas in the thyroid parenchyma. The other had multiple small areas giving a spotty appearance not previously reported in de Quervain's. Both patients demonstrated remarkable shrinkage of the gland (to 17.4% and 57% of the original presenting volume). We believe this is a useful diagnostic feature of de Quervain's thyroiditis.

Adult↗

Hepatocellular carcinoma in Hong Kong: clinical study on 340 cases.

Three hundred and forty cases of hepatocellular carcinoma in Hong Kong were studied for their clinical features, and various factors were analysed for their prognostic values. The clinical presentation was often vague and rather non-specific and a majority of patients were presented late and often unresectable. The overall median survival was 8 weeks. The Karnofsky performance scale and bilirubin level were the most important prognostic factors. The treated group survived longer than the untreated group.

Adolescent↗

The value of computed tomography in the diagnosis and management of bronchiectasis.

In order to evaluate the usefulness of computed tomography (CT) in the diagnosis and management, as distinct from only the diagnosis, of bronchiectasis, we retrospectively reviewed the clinical, lung function, and radiological data of 38 patients suspected of having the disease. All had chest radiographs, CT scans, and bronchograms. The approach was to examine the radiological investigations with the clinical data in three stages: I, chest radiograph; II, CT; III, bronchography (BG), as if they were newly presenting cases. At the end of each stage, a decision was made either to proceed to the next stage or to stop because further investigation was considered unlikely to alter management. Apparent normality, equivocal abnormality, or unilateral abnormality were criteria for proceeding. Unfitness for surgery, unequivocal bilateral disease, or mild disease were criteria for stopping after a firm diagnosis had been made. We stopped at stage I in four patients (11%) because the chest radiograph showed bilateral bronchiectasis and two had poor lung function. We stopped at stage II in 15 patients (39%): 12 had bilateral disease on CT; three had unilateral disease on CT but their clinical features were so mild that BG was considered unjustified. Scrutiny of the CT and BG films of those patients who were judged not to require CT or BG in the retrospective review confirmed that these would not have altered their management. Of the remaining 19 patients who proceeded to stage III, BG was useful in 15 (39%) by confirming or refuting CT findings, but was not useful in four (11%) because of underfilling. We conclude that optimal use of chest radiographs and CT in patients suspected of having bronchiectasis can significantly reduce the necessity of performing BG.

Adult↗

Endoscopic management of postoperative biliary fistula.

Endoscopic retrograde cholangiography (ERC) was performed in two patients with persistent bile fistulae after cholecystectomy. Contrast leakage was demonstrated in a leaking cystic duct stump and an aberrant intrahepatic duct. Endoscopic insertion of nasobiliary catheters led to rapid drainage and healing of the biliary fistulae.

Adult↗

The prevalence and pattern of pulmonary thromboembolism in the Chinese in Hong Kong.

The prevalence and clinical pattern of pulmonary thromboembolism was studied by a multifaceted approach. This documented the occurrence of pulmonary thromboembolism among the Chinese and confirmed an increasing incidence in Hong Kong, although comparatively it was still much lower (about one-tenth) than that found in western communities. Their clinical pattern, regarding presentation, risk factors, clinical features and response to thrombolytic therapy, conformed well with those reported in the west, but perhaps appeared in a milder form. The strong association of pulmonary thromboembolism with varicose veins and immobilisation would appeal for recommending routine heparinisation in Chinese patients having these combinations. Our findings will stimulate more interest in the comparative study of the haematological profile and the ethnic particulars of the Chinese.

Adult↗

Early myositis ossificans: a new echographic sign.

A case of soft tissue swelling of the thigh in which myositis ossificans developed is presented. A series of ultrasound examinations showed previously unreported changes which suggested the diagnosis. The use of ultrasound and other imaging modalities in this condition are discussed and the ultrasound appearances are related to the histology.

Adolescent↗