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Biomedical subjects

C Messmer

Publications and source records attributed to C Messmer.

8 recordsLinked to original sources
PubMed2002

Limb salvage with tumor endoprostheses for malignant tumors of the knee.

Data of 64 consecutive patients with malignant tumors of the knee treated with tumor endoprostheses between 1976 and 1996 were reviewed. The study was retrospective before 1990 and prospective since then. Four patients were lost to followup and are not included in the study. The average age of the remaining 60 patients was 33.2 years (range, 9-72 years). Fifty patients had surgery for primary sarcoma and 10 patients had surgery for metastases of carcinoma. In the patients in the sarcoma group, the probability of 5 years survival was 72% and 10 years survival was 69%. The overall clinical score of 47 patients with a followup more than 9 months was 81% using the evaluation system of the International Society of Limb Salvage. Fifty-eight reoperations were done in 29 patients because of complications. Twenty reoperations were attributable to soft tissue complications, 34 reoperations were because of mechanical problems related to the prostheses, and four were because of local tumor recurrence. The probability of survival of the leg of the patient after 10 years was 95%. Despite a high rate of complications after limb salvage with endoprostheses, the final clinical outcome usually was good.

Adolescent↗
PubMed2001

Prolonged iron depletion after allogeneic 2-unit RBC apheresis.

BACKGROUND: Allogeneic 2-unit RBC apheresis is a safe procedure offering many advantages for donors and blood banks. A controlled study was performed to determine whether the recommended minimum interval of 4 months between 2-unit RBC apheresis donations is appropriate in terms of the recovery of RBCs and the regeneration of iron stores. STUDY DESIGN AND METHODS: Twenty male subjects each donated 2 units of RBCs by apheresis. The RBC count, reticulocyte count, EPO, and measures of iron status were analyzed before and during the 4 months after donation. RESULTS: A significant decrease in Hb (15.89 +/- 0.82 [mean +/- SD] vs. 14.08 +/- 0.97 mg/dL, baseline vs. Day 7; p<0.001) was equalized within 2 months. In contrast, ferritin values declined significantly from 54.2 +/- 33.7 to 23.42 +/- 21.94 microg per L (predonation vs. Day 30) and remained significantly below predonation values, but within the normal range, until the end of the study period. CONCLUSION: A donation interval of 4 months is appropriate in terms of RBC recovery, but may not be appropriate in terms of iron store regeneration. The tendency to shorten the donation interval should be reconsidered in light of the measurements of iron storage. The use of ferritin levels is recommended as a preselection criterion for allogeneic 2-unit RBC apheresis.

Adult↗
PubMed1997

[Conservative treatment of cruciate ligament rupture. Magnetic resonance tomography provides prognostic information for conservative healing].

Ruptures of the cruciate ligaments continue to pose both diagnostic and therapeutic problems. On the basis of structural analysis of MR images obtained after the accident and the results of conservative treatment, it can be shown that function healing of the rupture can result, when, for example, the synovial membrane (capsule) is preserved (70%). It proved possible to show and objectify this using MRI and measurements.

Anterior Cruciate Ligament↗
PubMed1991

Influence of betaxolol and timolol on the visual fields of patients with glaucoma.

In a double-masked study, 40 patients with primary open-angle glaucoma were randomly assigned to treatment with betaxolol 0.5% or timolol 0.5% in both eyes twice daily. Visual fields and intraocular pressures were studied. Perimetry was performed with the Octopus G1 program two weeks after a washout period and three, six, 12, and 18 months after initiation of treatment. Both drugs reduced intraocular pressure. The reduction in intraocular pressure in the timolol-treated group was more pronounced than that in the betaxolol-treated group; the difference, however, was not statistically significant. In both treatment groups, the visual fields tended to improve during the first six months of treatment and remained stable or tended to deteriorate thereafter. The treatment effect on the visual field was better in the betaxolol-treated group than it was in the timolol-treated group (P = .041).

Aged↗
PubMed1991

[Effect of betaxolol and timolol on visual fields in glaucoma patients].

In a prospective, randomized, double-masked study, primary open-angle glaucoma patients were treated twice daily with either betaxolol 0.5% or timolol 0.5%. Patients received a pretreatment baseline examination following a 2 week washout period; they were then examined after 3 and 6 months of treatment. Each examination included visual field measurements with an Octopus automated perimeter and intraocular pressure measurement. The visual fields of the betaxolol group showed on the average a pronounced tendency toward improvement (MD decrease of 2.05 dB); visual fields in the timolol group showed a slight tendency toward improvement (MD decrease of 1.56 dB). The difference between these 2 trends after 6 months was statistically not significant (p greater than or equal to 0.05, U-test). Both drugs lowered intraocular pressure, there was no significant difference between the two drugs (p greater than or equal to 0.05, U-test).

Betaxolol↗
PubMed1991

Octopus program G1X.

The glaucoma program G1 is widely employed by Octopus users. In addition to a specific distribution of test locations, its main advantages are the quick comparison of results with normal values and an easy follow-up. The program, however, is relatively time consuming and, therefore, tiring for some patients. For this reason, the program was modified to 'G1X'. This program is interruptable at any time and provides information, including statistical analysis based on the available data. The test sequence is rearranged in accordance with the importance of the information. The available information, including the confidence limits, is continuously calculated and presented on the screen of the Octopus 1-2-3 during the test procedure. This provides the possibility of adapting the measurement to the patients and their state of health. The principal features as well as clinical applications are described.

Glaucoma↗
PubMed1990

[The Opacity Lens Meter 701: clinical experiences].

The quantitative influence of cataracts on visual fields was studied in 11 patients before and after cataract extraction with intraocular lens implantation. Lens opacity, measured with the Opacity Lens Meter 701, correlated closely with the visual field changes. Measurement of stray light backscattered from the cataractous lens permits quantitative prediction of the influence of cataract on the visual field.

Aged↗