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Biomedical subjects

C Merlini

Publications and source records attributed to C Merlini.

At least 37 records · Page 2Linked to original sources
PubMed1988

Double-blind trial RU 41740 vs. placebo: immunological and clinical effects in a group of patients with chronic bronchitis.

A double-blind trail was performed to investigate the effects of RU 41740, a glycoprotein extract from Klebsiella pneumoniae, on host defenses and its efficacy in reducing the number of exacerbation in 29 evaluable patients with chronic bronchitis, out of 36 patients who entered the study. The drug enhanced the phagocytosis indexes of both polymorphonuclear and mononuclear phagocytes. Increased candidacidal activity of monocytes was also observed. These effects, already detectable after one course of therapy and during the entire period of treatment, were no longer detectable when tested 6 months after the end of treatment. A significantly (p less than 0.05) larger number of patients in the treated group than in the placebo group had no exacerbations during drug administration (0-3 months). Moreover, patients treated with RU 41740 had significantly fewer and shorter episodes of acute exacerbation. The positive decreases in these two parameters persisted throughout the follow-up.

Adjuvants, Immunologic↗
PubMed1987

In vitro and ex vivo influence of rifamycins on human phagocytes.

We studied the effects of rifamycin SV, rifampicin and rifapentine on human phagocyte functions. Rifamycins inhibited in vitro neutrophil chemotaxis in the range of their therapeutic levels, and they significantly affected the survival of a rifamycin-sensitive strain of Staphylococcus aureus inside human monocytes. Both effects were related to the intraphagocytic penetration of these antibiotics. For the ex vivo studies, 600 mg of rifampicin were orally administered to five subjects with defective S. aureus killing. A significant reduction of neutrophil chemotaxis and increased activity against S. aureus were shown 150 and 210 min after administration of the drug.

Chemotaxis, Leukocyte↗
PubMed1985

[Flap design].

Explore the source record for details and available documents.

Apicoectomy↗
PubMed1980

[Clinical and therapeutic studies of pancreatitis].

The literature on the medical management of pancreatitis is reviewed. Reference is made to successful results obtained in 30 personal cases with a semimedicamentous protocol, in which an antipancreatitic activity in the true sense was obtained by administering aprotinine and glucagon. Eight subjects presented acute or recrudescent chronic forms, 12 pancreatitis combined with cholelithiasis, 5 secondary forms following penetrating duodenal ulcers, and 5 forms arising after stomach, duodenal or bile duct surgery. The evaluation of each case is described and the conclusion is drawn that intensive, timely medical therapy will secure resolution in the majority of cases.

Adult↗