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Biomedical subjects

C McCulloch

Publications and source records attributed to C McCulloch.

At least 37 records · Page 2Linked to original sources
PubMed1983

Pathological and surgical examination of the handling of the lacerated eyeball.

A survey of 85 lacerated eyeballs pointed to six elements that had led to destruction of the globe: poor wound closure, hypotony, hemorrhage, lens remnants, fibrosis and antigen exposure. Guidelines for the repair of such globes were established on the basis of the pathological findings. The techniques necessitate great care and require the use of a microscope, a vitreous aspiration cutter and fine sutures. Adequate time must be set aside for the surgery, since anything less than careful and complete repair can lead to disaster. The quality of the primary repair is likely to be what defines the excellence of the final result.

Eye↗
PubMed1982

Amiodarone-induced cornea verticillata.

Among 37 patients treated with amiodarone, an antiarrhythmic drug, a typical keratopathy developed in 35, none of whom had ocular complaints. The keratopathy resembled that seen with Fabry's disease and chloroquine use, as did the membrane-bound lamellar bodies detected by electron microscopy in all layers of the corneal epithelium in the one patient with marked keratopathy in whom a corneal biopsy was performed; membrane-bound bodies, mostly granular, were also noted within this patient's stromal keratocytes. The possible pathogenesis of the keratopathy as a type of drug-induced lipidosis is discussed.

Adult↗
PubMed1981

Distribution of silver in the eyes and plasma proteins of the albino rat.

Albino rats were given a 0.25% solution of silver nitrate to drink for 10 weeks, then were divided into two groups. One group continued to drink the solution for an additional 6 months, while the other group was given water to drink for an additional 12 months. The ingestion of silver nitrate retarded the growth of the rats and eventually caused their death. The rats regained weight and appeared to grow normally when the silver nitrate regimen was withdrawn. Radioactive silver in the plasma was found to be almost exclusively in a single electrophoretic protein band. Examination of the rats' eyes by electron microscopy showed deposits of silver particles in Bruch's membrane, the basement membranes of the choriocapillaris and the ciliary processes, and the stroma of the choroid and ciliary processes. The number and size of the particles increased with continued ingestion of silver but decreased if the silver regimen was withdrawn after the initial 10 weeks of ingestion. Fine particles of silver were still present 12 months after the end of the ingestion of silver nitrate. At no time were silver particles seen in the basement membranes or endothelial cells of the retinal capillaries or within the cytoplasm of the pigment epithelium or the epithelial cells of eh ciliary processes.

Animals↗
PubMed1980

Treatment of gyrate atrophy of the choroid and retina with low arginine diet.

In gyrate atrophy the blood ornithine is grossly elevated, due to deficiency of ornithine ketoacid transaminase, which converts ornithine towards glutamic acid. Two patients with gyrate atrophy have been treated with a low arginine diet and their blood ornithine levels have been reduced to near normal. At this level hyperammonemia may result from overtreatment, but this can be quickly cleared by a small dose of arginine. There has also been some improvement in vision, but no clearing of the gyrate areas. Future care with this regimen seems possible and improvements in handling of these patients are likely.

Adolescent↗
PubMed1980

The formation of collagen and its relation to ophthalmic diseases (first of two parts).

In this first part of the review the assembly and structuring of collagen to form various types of fibrous tissue are described. Intracellularly this involves translation of the genetic code of nuclear DNA into chains of amino acids in the endoplasmic reticulum, hydroxylation, glycosylation and winding of these chains into the triple helix of procollagen, which is then extruded into the extracellular space. Extracellularly procollagen is converted to tropocollagen, which is then aligned and cross-linked into fibres by both enzymatic and nonenzymatic processes.

Amino Acids↗
PubMed1979

Hereditary lens dislocation with angle closure glaucoma.

Eight patients in one family showed dislocation of the lens and secondary angle-closure glaucoma coming on in the 50's. They all displayed the sequence of myopia, angle shallowing, followed by angle-closure glaucoma. This sequence should alert the clinician to the possibility of a hereditary disease. The cause of the disease is unknown. It is suggested that treatment should be an iridectomy in the early stages and a lens extraction if glaucoma develops.

Age Factors↗
PubMed1979

Epithelial downgrowth following cataract extraction.

This case of epithelial downgrowth following cataract extraction shows the typical sequence of a noneventful cataract extraction with satisfactory recovery but after a time, the appearance of conjunctival injection, iritis and attacks of elevated ocular pressure. A minimal membrane on the posterior surface of the cornea could be seen but the diagnosis rested on the sequence of events and was confirmed by the pathologic investigation. The apithelial cells grow freely on the iris, but extend onto the cornea and posteriorly apparently without hindrance. The epithelial cells form a basement membrane next to the iris, much as they do on the surface of the cornea next to Bowman's membrane. The source of the cells in this case was not identified; they presumably came from conjunctiva although no track through the sclera was found and the cells themselves did not show goblet cells.

Aged↗
PubMed1978

Whorl-like degeneration of corneal epithelium a clinico-pathologic study.

A case of epithelial corneal degeneration that was first seen as a pigmented plaque but changed to a whrol-like pattern and then partially regressed is described. The pathologic abnormality was an intra-cellular inclusion of lipid in the basal cells and of lipid and mucopolysaccharide in the wing and superficial cells. No duplication of basement membrane or thickening of Bowman's layer was present. It is suggested that despite different origins the pathologic entity in this case, in Fabry's disease and in chloroquine keratopathy is similar. The whorled pattern is due to a sliding of the corneal epithelial cells as they rise from the basal cells to the surface, much as a cyclonic flow forms about an atmospheric low in the southern hemisphere.

Aged↗
PubMed1978

A coronary teaching program in a community hospital.

In conclusion, the teaching program we developed appears to meet the needs originally established by the audit. Nurses are provided with a method of assessment, evaluation, and documentation. The program also provides a means of teaching continuity while following a structured time schedule that allows for recognition and satisfaction of individual patient needs. The patient teaching record provides the final tool as a reference and ongoing source of evaluation.

Coronary Disease↗
PubMed1977

Crystalline dystrophy of the cornea: a light and electron microscopic study.

We examined biopsy material from a case of stromal crystalline dystrophy of the cornea by light and electron microscopy. Frozen sections were positive for neutral fat and negative for cholesterol. Electron microscopy showed that the empty spaces at the site of the crystals did not have typical crystalline profiles. We concluded that in our case the crystals were composed of neutral fat.

Adult↗
PubMed1977

The presence of cell-mediated immunity in uveitis.

We have attempted to demonstrate cell mediated immunity in cases of uveitis. We tested blood samples of patients for leucocyte migration inhibition (LMI) and lymphocyte transformation (LT). The gel diffusion test was used to detect humoral antibody. Allogeneic uveal, retinal and corneal antigens were prepared for the tests from eye bank eyes. The LMI and LT tests gave positive results in 9 out of 16 cases. In these 9 cases 8 were positive to retinal antigen, three with corneal antigen and only one was positive against uveal antigen. Humoral antibodies were not detected. We suggest that cell mediated autoimmunity is present but the relationship of this to the uveitis itself is obscure.

Adolescent↗
PubMed1976

Optic disc observations in glaucoma.

In glaucomatous eyes, contrary to normal eyes, the blind spot size is not correlated with the disc or cup size, and the size of the optic disc, cup and optic rim also varies. The variation in area of the glaucomatous optic disc correlates with variation in area of the optic cup. The rim width and total rim area in glaucomatous eyes are decreased. In glaucoma the upper, lower and nasal rim widths are about the same, whereas the smallest rim width occurs temporally. Thus, clinically cupping in glaucoma eyes need not be vertically oval.

Glaucoma↗