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Biomedical subjects

C May

Publications and source records attributed to C May.

156 records · Page 9Linked to original sources
PubMedDate not supplied

CSF and serum concentrations of albumin and IgG in Alzheimer's disease.

Cerebrospinal fluid (CSF) and serum concentrations of albumin and immunoglobulin G (IgG) were measured in 31 patients with presumptive Alzheimer's disease (AD) and in 14 healthy control subjects. The albumin and IgG quotients, and IgG index were calculated to evaluate the permeability of the blood-brain barrier and the intrathecal production of immunoglobulins. X-ray computerized tomography (CT) of the head was performed to investigate the relation between cerebral atrophy and CSF protein concentrations. The albumin and IgG quotients, and the IgG index did not differ significantly between the AD and control groups. Cerebral atrophy, as measured by CSF volume, was not related to CSF protein concentrations in either group. The results do not support the hypothesized roles of blood-brain barrier disruption or of immunologically-mediated injury of the central nervous system in the pathogenesis of AD.

Aged↗
PubMedDate not supplied

Antibodies to heat shock proteins in dogs with rheumatoid arthritis and systemic lupus erythematosus.

Antibodies to heat shock proteins of the 65 kDa group were demonstrated in canine sera and synovial fluid. This paper reports these antibody measurements in three groups of dogs with joint disease and compares them with those of a control population. Dogs with rheumatoid arthritis (RA) showed higher anti-heat shock proteins (HSP) antibody levels, in both their sera and synovial fluids, compared to the control dogs and these antibodies were predominantly of the IgG and IgM class; there was a significant correlation between IgM anti-HSP65 and IgM-rheumatoid factors. There was also a significant correlation between anti-HSP65 and antibodies to canine distemper virus, but only of the IgM class and the relevance of these antibodies to the overall pathogenesis of canine RA and, in particular, to the presence of canine distemper virus within the joint, are discussed.

Animals↗
PubMedDate not supplied

Clinical terminology: anxiety and confusion amongst families undergoing genetic counseling.

Genetic counseling is a rapidly expanding, but highly demanding, domain of doctor-patient communication. This paper reports results from an ethnographic study of families (n = 30) attending a genetic counseling clinic in Northern England. We suggest that the language used in this particular specialty is often confusing and misunderstood by the families involved. We found that unfamiliar terms may also conjure up also conjure up alarming images. It is important therefore, that physicians, and in particular geneticists, try to use simple, understandable language, and give clear explanations for unfamiliar terms that cannot be avoided. The careful choice of words, and detailed explanation, not only reduces the risks of "labelling" and stigmatization, but may also prevent the unnecessary anxiety experienced by patients when they hear unfamiliar medical terms, such as the eponyms frequently employed by geneticists when giving a diagnosis.

Anxiety↗
PubMedDate not supplied

General practitioners' perceptions of the illness behaviour and health needs of South Asian women with menorrhagia.

OBJECTIVES: A study of general practitioners' (GPs) perceptions of the health needs of women of South Asian descent who suffer from menorrhagia. METHOD: A qualitative study using semi-structured interviews with 50 GPs in two British towns. FINDINGS: This study suggest that some women of South Asian descent may not consult their GPs even though suffering severe menorrhagia. Moreover, some GPs perceive that women may suffer from anaemia as the result of such illness behaviour. One reason for this reluctance to consult for menorrhagia may be the fact that some women of South Asian descent prefer to be examined by female doctors, yet may attend practices that lack a female partner. The study also shows that South Asian women, who consult male GPs for menorrhagia, are sometimes referred to hospital outpatients without internal examinations, and that women may be reluctant to keep their hospital appointments because of the lack of female gynaecologists. The study also indicates that a shortage of female interpreters may make communication difficult between some health care professionals and their patients, particularly when a complex and sensitive subject such as menorrhagia needs to be discussed. CONCLUSION: Women of South Asian descent may suffer serious problems such as iron deficiency anaemia, partly due to untreated menorrhagia. Since this was a study of GPs' perceptions of the health needs of South Asian women, it is now important to interview women themselves, to learn more about their perceptions of menorrhagia, and their perceptions of any subsequent contact with health care professionals.

Anemia, Iron-Deficiency↗
PubMedDate not supplied

Corticosteroids in infant chronic lung disease.

Chronic lung disease (CLD), defined as chronic oxygen dependency at 36 weeks postmenstrual age, is increasing and associated with chronic respiratory morbidity and high health care utilisation at follow up. Many strategies, tested in randomised trials, have failed to reduce CLD. In contrast, corticosteroids if given systemically within the first two weeks after birth reduce CLD and may also favourably influence survival. Unfortunately, systemically administered corticosteroids have many acute side-effects and adversely affect long term neurodevelopmental outcome. If given by inhalation, corticosteroids have fewer adverse effects, but are less efficacious. Further research is required to accurately identify infants at highest risk of developing CLD, the corticosteroid dosage associated with a positive risk: benefit ratio and preferably a safer and more effective alternative therapy.

Administration, Inhalation↗
PubMedDate not supplied

Talocalcaneal luxation with plantar displacement of the head of the talus in a dog and a cat.

A dog and a cat suffered talocalcaneal luxation with plantar displacement of the head of the talus. Each case was associated with luxation of the talocentral joint and subluxation of the calcaneoquartal joint. The collateral ligaments were not significantly disrupted and this made it technically difficult to reduce the luxations. However, after open reduction, the luxations were inherently stable and a positional screw provided long-term stability. Both animals returned to their previous level of activity with no detectable signs of lameness.

Animals↗
PubMedDate not supplied

The National Breast Screening Study: pre-recruitment sources of awareness in participants.

Data collected by questionnaire from 89,835 women on entry into 15 Canadian National Breast Screening Study (NBSS) centres reveal pre-recruitment sources of awareness: radio and television were reported by 30%; workplace 6%; friends 35%; physician 6%; and other by 23% of respondents. Personalized letters of invitation employed in 5 centres were an important source of awareness. In the age group recruited, 40-59 years, age had no influence on the source reported. However women with post-secondary school education were less likely to report radio and television as a source and more likely to report newspapers compared to women with less education. Women with only public school education were less likely to report the workplace as a source of awareness than women with post-secondary education. Recruitment strategies for screening programs may be more successful if publicity on radio and television is geared to women of lower educational status and if publicity in newspapers is geared to women of higher educational status, supplementing both with personalized letters of invitation.

Adult↗