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Biomedical subjects

C Masson

Publications and source records attributed to C Masson.

At least 199 records · Page 11Linked to original sources
PubMed1988

Autoimmune serum containing an antibody against a 94 kDa nucleolar protein.

Little information exists on how various nucleolar proteins function in ribosome biogenesis. Of special interest is that group of nucleolar proteins which are not incorporated into mature ribosomes because they are candidates for a role in the regulation of ribosome construction. Non-ribosomal nucleolar proteins can be analyzed using autoimmune sera from scleroderma patients which often contain antinucleolar antibodies. One such serum, designated ScBr, is shown by indirect immunofluorescence to react specifically with nucleoli in cells of 3 different mammalian species, indicating that the antigen is at least partly conserved evolutionarily. It is not RNase-sensitive, but is completely eliminated after incubation with pronase and 2 M NaCl. Immuno-electron microscopy was carried out on Lowicryl ultrathin sections to localize the antigen. The labeling was observed over both the granular and the dense fibrillar component but not the fibrillar centers, indicating that the antigen is associated with ribosomal RNA transcription sites and ribosome assembly into precursor particles. In addition, the antibody was localized to small nucleoplasmic entities, termed dense nuclear bodies. This could indicate a relationship between nucleoli and dense nuclear bodies. By immunoprecipitation, only a single protein of 94 kDa molecular weight was revealed. By immunoblotting, the band at 94 kDa was found to be the only positive band for high ScBr dilutions. Observation of the behavior of the antigen during mitosis revealed that it became dispersed into the cytoplasm after breakdown of the nuclear envelope, lining most of the chromosomes rather than remaining associated with the NOR-chromosomes. The antigen appeared to be restored to nucleoli only in late telophase; phase-dense prenucleolar bodies of early telophase cells did not show positive staining for the antigen. During actinomycin-D RNA synthesis inhibition as well as in non-stimulated lymphocytes the positive staining is greatly decreased. These results were consistent with a role for the 94 kDa nucleolar protein in the process of preribosome assembly.

Animals↗
PubMed1988

[Expression of pain in rheumatic disease. Exploratory study].

An investigation done in 34 rheumatology departments on 259 patients in order to analyse their perception of pain and its repercussions on daily living. The main three diseases justifying hospitalization are: rheumatoid arthritis, lumbosciatica and bone neoplasia. In these patients, pain occurs daily in 75 p. cent of them and continuous in 32 p. cent; the intensity of the pain varies according to the time. There are repercussions on work (63 p. cent), walking (81 p. cent), but also on leisure (74 p. cent), friendly interelations (42 p. cent) and disposition which is disturbed in 62 p. cent of patients. Behavioral analysis in the presence of pain brings up differences depending on the patients: the elder the patient, the least they are able to respond to the handicap caused by pain. Analysis of the pain vocabulary suggest that if the terms expressing the experience of the patient are different according to the diseases, the usual description of painful phenomena are common to patients and the diseases in question.

Adult↗
PubMed1988

[Eales' disease with neurologic disorders].

Two cases of Eale's disease, with neurological involvement have been studied with magnetic resonance imaging (MRI). In the first case the ophthalmological disease had been diagnosed ten years before the onset of a cerebellar ataxia. In the second case the characteristic ocular changes were followed eight years later by a myelopathy. MRI in both cases showed multifocal white matter abnormalities. The nosological interpretation of such cases remains uncertain: association of Eale's disease with multiple sclerosis or vasculopathy involving the central nervous system and the retina?

Adult↗
PubMed1988

[Epilepsy with bilateral cortical calcifications. Discussion of a durable post-critical deficit].

The epilepsy-bilateral cortical calcifications syndrome includes epilepsy with onset in childhood or adolescence and symmetrical calcifications of cerebral cortex with a predilection for the occipital cortex. The calcifications are sometimes visible on plain radiograph images but may be detected only by CT. Literature perusal revealed reports of 16 cases. We report a case with an aperceptive visual agnosia and marked but resolutive CT anomalies developed during a partial status epilepticus episode.

Adolescent↗
PubMed1988

[What lesions of the myometrium are responsible for hemorrhage?].

Based on a personal series of 54 cases of endo-uterine haemorrhage with normal endometrium, the authors show that lesions of the myometrium which may result in haemorrhages, consist mainly of interstitial or submucous myomas and adenomyosis, i.e. lesions on which medical treatments are ineffective. Ultrasonography, but mainly clinical data and hysterography very often demonstrate the lesions and are sufficient to indicate a hysterectomy or a myomectomy. The problem is more difficult when the clinical, ultrasonographic and hysterographic work-up is negative or barely evocative. In these cases, after ruling out certain functional haemorrhages or a haemorrhagic disease, it is useful to take an histological sample of the endometrium either by curettage or biopsy, on an ambulatory basis (using Inocurette for instance). If this examination is normal, hysterectomy is indicated, because, in their experience, there are such lesions of the myometrium, that recurrence of the haemorrhages is inevitable.

Adult↗
PubMed1988

[Graphomania. Compulsive graphic activity as a manifestation of fronto-callosal glioma].

The presenting symptomatology in a case of fronto-callosal glioma were affective indifference, severe disorders of attention and dynamic aphasia with marked reduction in spoken expression. Spontaneous and induced writing were abundant and incoercible. Their meticulous production and formal correction contrasted with its semantic incoherence. This behavior is comparable with that of the compulsive activity that may result from pallidal lesions or bilateral frontal lesions. The term graphomania is proposed to distinguish this behavior from echographia and hypergraphism.

Aged↗
PubMed1988

Albendazole sulfonation by rat liver cytochrome P-450c.

The metabolism of albendazole (ABZ) was studied in perfused livers from control and ABZ-treated rats (10.6 mg/kg, per os, each day for 10 days). In the perfusion fluid, the concentration of ABZ-sulfoxide (SO-ABZ) remained unchanged in treated, as compared to control animals, whereas ABZ-sulfone (SO2-ABZ) was increased in treated animals. In bile, only SO-ABZ was present. The transformation kinetics of SO-ABZ to SO2-ABZ in microsomes from rats treated with ABZ, 3-methylcholanthrene, Aroclor and isosafrole were biphasic. This suggests that enzyme activity was a consequence of two enzyme systems, one characterized by low affinity and high capacity, the other by high affinity and low capacity, the latter could be induced by 3-methylcholanthrene, ABZ, Aroclor and isosafrole. Cytochrome P-450c was induced potently in vivo by ABZ as proven by increased monooxygenase (7-ethoxyresorufin and 7-ethoxycoumarin-O-deethylase) activities and by Elisa test (a 5-fold increase in hemoprotein concentration was observed). Purified and reconstituted cytochrome P-450c from 3-methylcholanthrene or ABZ-treated rat liver were able to produce SO2-ABZ (2.01 and 1.70 nmol/mg/15 min, respectively, whereas cytochrome P-450b produced 10 times less SO2-ABZ). Immunological assays, as well as activity measurements showed a relationship between cytochrome P-450c-3-methylcholanthrene and cytochrome P-450c-ABZ. We conclude that induction of cytochrome P-450c by ABZ is the probable explanation for the enhanced formation of SO2-ABZ in vivo.

Albendazole↗
PubMed1987

Release pattern of the vascular plasminogen activator and its inhibitor in human postvenous occlusion plasma as assessed by a spectrophotometric solid-phase fibrin-tPA activity assay.

Vascular or tissue-type plasminogen activator (plasma t-PA) is the circulating physiological fibrinolytic enzyme of endothelial cell origin which function is regulated by fibrin and a specific inhibitor (PAI). To study the pattern of release of t-PA and the behavior of t-PA-PAI complexes in plasma we determined t-PA activity in 44 healthy subjects before and after 10 min of forearm venous occlusion using a new spectrophotometric solid-phase fibrin-tPA activity assay. The assay is based on 1) the high affinity binding of t-PA to fibrin, and 2) the detection of fibrin-bound t-PA by measuring the release of pNA from a chromogenic substrate in the presence of plasminogen. Values at rest were rather undetectable in plasma (0.05 +/- 0.03 IU/ml, in 23 out of 44 samples) but were positively detected in all the euglobulins: 0.88 +/- 0.68 IU/ml. After venous occlusion the majority of plasmas (36 out of 44) showed a slight increase in t-PA activity (0.65 +/- 0.63 IU/ml) as compared to the important level observed in all the euglobulins (9.78 +/- 9.58 IU/ml). So, the ratio plasma/euglobulin t-PA activity was very low (0.06) and remained identical in both pre- and postocclusion samples. However, when diluted plasmas were tested the inhibitory effect disappeared and t-PA activity increased indicating that although t-PA circulates in a neutralized state it can be available for fibrinolysis.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1987

[Neurologic aspects of Lyme disease].

The neurological manifestations of Lyme disease--a condition caused by a spirochete (Borrelia burgdorferi) and transmitted by a tick Ixodes dammini)--consist of chronic lymphocytic meningitis, cranial neuritis and radiculoneuritis associated to varying degrees. The tick-borne meningoradiculitis well known in Europe (Garin-Bujadoux-Bannwarth syndrome) appears, with very slight differences, as equivalent to the neurological manifestations of Lyme disease. Lesions of the central nervous system, which occur long after the B. burgdorferi infection, are thought to represent a tertiary stage of Lyme disease.

Bites and Stings↗
PubMed1987

The grafting of burns with cultured epidermis as autografts in man. Two case reports.

In two patients full-thickness burns were grafted with cultured autologous epidermis obtained using the technique described by H. Green. The grafts only took partially but produced satisfactory covering. Better efficiency and more information about the long-term characteristics of the resulting skin are necessary before routine use can be recommended.

Adult↗
PubMed1987

[Amnesia and stiff-man syndrome. Manifestations disclosing paraneoplastic encephalomyelitis].

The authors report a case of hypertonia, the clinical and electrophysiological features of which were identical to those of the Stiff-man syndrome first described by Moersch and Woltman in 1956. This and the five other previously reported cases can be attributed to encephalomyelitis of the anterior horns of the spinal cord. All of these cases had severe but partial involvement of the anterior horns and the probable physiopathological mechanism of the resulting contractures was elective destruction of the small inhibitory neurones. In the present case, the association of a limbic encephalitis and secondary exteriorization of a carcinoma of the pharynx, strongly suggested a paraneoplasic encephalomyelitis. This is the first report indicating an association between the Stiff man syndrome and a paraneoplastic syndrome. Another point of interest was the spectacular response of the hypertonia to steroid therapy suggesting a central neuropharmacological effect quite apart from the non specific anti-inflammatory action on the encephalomyelitis.

Amnesia↗
PubMed1987

[Auditory hallucinations in lesions of the brain stem].

Since the publication by Jean Lhermitte in 1922 of his paper on hallucinosis, the peduncular type has been described as a purely visual phenomenon. However, limited brain stem lesions can give rise to analogous manifestations in the auditory field. Five cases of auditory hallucinosis are reviewed, the first four resulting from a lesion of tegmentum of pons responsible for contralateral hemi-anesthesia and homolateral facial palsy with paralysis of laterality. Central type hypoacusis and a severe disorder of localization of sounds revealed a lesion of trapezoid body. The fifth case resulted from a peduncular lesion in region supplied by superior cerebellar artery, the auditory deficit being related to a lesion of inferior corpus quadrigeminum. In one patient, the auditory hallucinosis was followed by a period of visual hallucinations and oneiric delusions. Both auditory and visual hallucinosis can be related to hypnagogic hallucinations. Dream mechanisms (the geniculo-occipital spikes system) escape from normal inhibitory control exerted by the raphe nuclei. Auditory deafferentation could predispose to auditory hallucinosis.

Aged↗
PubMed1986

[Adrenoleukodystrophy and adrenomyeloneuropathy].

In adrenoleukodystrophy, demyelinization of the cerebral hemispheres is associated with Addison's disease. The condition is hereditary and transmitted as a sex-linked recessive trait. The diagnosis must be considered in male teenagers with deterioration of mental functions, motricity and vision and with a computed tomographic image of white matter hypodensity predominant in the posterior part of the cerebral hemispheres. An accumulation of very long chain fatty acids, and characteristic lamellar cytoplasmic inclusions are the biochemical and ultrastructural markers of the disease. Adrenomyeloneuropathy differs from adrenoleukodystrophy in that it begins during adulthood and produces neurological symptoms, notably progressive spastic paraparesis associated with peripheral neuropathy. Heterozygous women can be identified by measurements of very long chain fatty acids in plasma and fibroblast cultures; they sometimes develop spastic paraparesis. The prenatal diagnosis rests on the determination of very long chain fatty acids in amniotic cells.

Adrenoleukodystrophy↗
PubMed1986

[Joint manifestations in chronic T-cell lymphocytosis and neutropenia].

The authors report the case of a patient suffering from chronic T-cell lymphocytosis and neutropenia (CTLN), detected from seropositive rheumatoid arthritis with attacks of fever. The distinctive features of CTLN, isolated from other forms of chronic T-cell lymphoid leukemias, are recalled. The frequency and nature of joint signs found during this new hematologic entity are described.

Agranulocytosis↗