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Biomedical subjects

C Martin

Publications and source records attributed to C Martin.

At least 1,387 records · Page 77Linked to original sources
PubMedDate not supplied

Acetylated low-density lipoproteins promote the release and metabolism of arachidonic acid by murine macrophages.

We studied the effect of acetyl-LDL on the synthesis of eicosanoids by primary cultures of mouse-resident peritoneal macrophages. A dosis of 150 micrograms of acetyl-LDL proteins promotes a maximal release of arachidonic acid metabolites into extracellular medium. This process is very rapid and reaches the maximal value about ten minutes after stimulation. The pattern of arachidonic acid metabolites released is different from that obtained when the cells are stimulated with a phagocytosable particle like zymosan or calcium ionophore A23187. The data show that the metabolism of arachidonic acid by cycloxigenase is diminished. In an unusual way the amounts of prostaglandin PGE2, 6-keto-prostaglandin PGF1 alpha and thromboxane TXB2 synthesized are similar.

Acetylation↗
PubMedDate not supplied

[Treatment of 100 acute myeloid leukemias (author's transl)].

Between november 1974 and august 1976, 100 acute myeloïd leukemias were treated by the same protocol L. 275. Induction treatment was daunorubicine, vincristine, cytosine arabinoside, in one intensive course for patients under 65 and cyclophosphamide (CPM), VCR and CAR in a less intensive and repetitive courses for patients over 65. In remission, there were three phases: consolidation, prevention of central nervous system leukemia, maintenance. All patients in remission received an androgenotherapy and two groups were randomised: chemotherapy and chemotherapy plus BCG. 68 patients were in complet remission (CR) 61 out of 80 patients under 65 and 7 out of 20 over 65. Median duration of first remission was 12 months. Median duration of survival was 13 months for all patients, 15 months for patients under 65, 3 months for patients over 65, and 22 months for 68 patients in CR. Survival of patients receiving BCG was slightly better than patients without BCG.

Adolescent↗
PubMedDate not supplied

[Alcoholism, colic diverticular disease and metabolic disorders (author's transl)].

70 patients with colic diverticular disease and 50 control subjects were compared. Sexes and ages were matched in the two groups. Significant higher frequencies of alcoholism (P < 0,00001), hyperlipidemia (P < 0,0001), impaired oral glucose tolerance test (P < 0,001), hyperuricemia (P < 0,01) and atherosclerosis (P < 0,000001) were noted in the diverticular group. Hypothesis about pathogenesis of diverticular disease are suggested.

Adult↗
PubMedDate not supplied

[Lipemia and apolipoproteinemia B in overweight, smoking men aged 30 to 55 years].

Serum concentrations of total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides and apolipoprotein B were studied in male subjects with no known risk factor for coronary heart disease. Overweight in this study was associated with higher serum cholesterol concentrations and lower HDL-cholesterol levels. The effects of cigarette smoking on the concentrations of HDL-cholesterol and LDL-cholesterol appear to be prominent in the heavy smoking subjects (p less than 0.010 and p less than 0.050 respectively). A positive association between cigarette smoking and serum triglycerides was found. This work suggests that HDL-cholesterol is the best indicator to discriminate both cigarette smokers or subjects having overweight at risk of developing atherosclerosis or coronary heart disease.

Adult↗
PubMedDate not supplied

Delayed hypersensitivity skin reactions in the induction phase of remission in acute non lymphoid leukemias.

Delayed skin reactions to Tuberculin (10 units, intradermal) and Candidin (1:1000, intra dermal) were studies in a homogenous group of 41 patients with acute non lymphoid leukemias in their initial phase. Remission-rate is higher in non-anergic patients (63%) than in anergic patients (32%), (p less than 0.05). Death-rate (within 30 days after chemotherapy) is higher in anergic patients (50%) than in non-anergic patients (16%), (p less than 0.05). There is no correlation between delayed skin reactions and age, initial absolute counts of neutrophil-lymphocyte-monocyte-blast cells, and results of humoral immunity. Delayed skin reactions are interesting in defining a high-risk group in the induction phase of remission of acute non lymphoid leukemias.

Acute Disease↗
PubMedDate not supplied

Spermidine uptake by erythrocytes from normal and Lewis lung carcinoma (3LL) grafted mice: II. In vivo study.

During Lewis lung carcinoma (3LL) growth, red blood cell (RBC) spermidine (Spd) level evolution was proportional to the increase in tumor volume and inversely correlated with the decrease in tumor Spd concentration. Similarly, in cancer mice i.p. injected with [14C] Spd, the increasing amount of erythrocyte [14C] Spd was in proportion with tumor volume enhancement and linked to decrease in tumor tissue [14C] Spd concentration. After i.p. injection of [14C] Spd putrescine or [14C] spermine, contrary to normal mice, cancer mice provided [14C] Spd in their erythrocytes. When injected with [14C] methionine, [14C] polyamines were never found in normal or cancer mice erythrocytes. As previously noted in vitro, increasing amounts of polyamines produced by tumor tissue and excreted into blood would modify erythrocyte stroma proteins involved in the RBC [14C] Spd uptake process. These data obtained in vivo demonstrate the tumor origin of polyamines carried by erythrocytes. Since RBC polyamine levels are directly correlated with tumor progression, these experimental results reinforce the clinical use of this index of cell proliferation in malignant diseases with a short doubling time.

Animals↗
PubMedDate not supplied

[Hypercalcemia in pseudohypoaldosteronism].

The authors report a case of pseudohypoaldosteronism with hypercalcemia. Treatment with sodium chloride supplements normalized both plasma electrolytes and calcium, and allowed normal physical development.

Aldosterone↗
PubMedDate not supplied

T cell subsets in multiple sclerosis. A longitudinal study of exacerbating-remitting cases.

Twenty-four untreated MS patients with exacerbating-remitting disease were longitudinally studied for T-cell subset distribution within peripheral blood, using monoclonal antibodies OKT3, OKT4 and OKT8. A decreased percentage of OKT8 reactive cells, with a correlative increase of the OKT4/OKT8 ratio, was detected in relapsing MS patients, in most cases within 2 weeks before and 1 week after the onset of relapse. Longitudinal analysis of individual fluctuations allowed to detect during relapse an increase of OKT4/OKT8 ratio over the value recorded during remission in 78% of MS patients. Only 50% of patients however exhibited an OKT4/OKT8 ratio exceeding the 5% confidence upper limit of healthy control values. Relapse was more often associated with T-cell subset abnormalities in patients who suffered several attacks during the period of study. MS patients in remission, when considered as a group did not show significant abnormalities of the T-cell subset balance, although some individuals did present with wider T-cell subset fluctuations than healthy controls.

Adolescent↗
PubMedDate not supplied

[Pharmacokinetic study of cefotaxime in newborn infants and infants].

The serum kinetics of intravenous cefotaxime was studied in 13 neonates and 5 infants presenting with bacterial infections in order to establish the dosage and route of administration. Average dosage was 66.6 mg/kg/day in neonates and 62 mg/kg/day in infants. Cefotaxime was given intravenously in 3 daily bolus injections in infants and 2 bolus injections in neonates under 8 days of age. In infants the average serum peak was 173 mcg/ml at 15 min. Serum half-life was between 0.45 and 0.50 hr (T 1/2 beta) close to the one found in adults. In neonates the average serum peak was 106.2 mcg/ml at 35 min. Serum half-life was 1.71 hr (T 1/2 beta). It is prolonged in neonates who are younger, more premature and have a lower weight. In full term neonates, during the first 8 days, the desirable dose seems to be 75 to 150 mg/kg/day in 3 injections, according to the severity of the infection. In premature neonates under 8 days of age, the interval between injections should be increased up to 12 hrs. Finally, in full term neonates older than 8 days and in infants, one injection every 6 hours seems to be advisable.

Bacterial Infections↗