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Biomedical subjects

C Marks

Publications and source records attributed to C Marks.

At least 127 records · Page 7Linked to original sources
PubMedDate not supplied

Pattern of arterial aneurysms in acquired immunodeficiency disease.

The ever-spreading incidence of infection with the human immunodeficiency virus (HIV) has introduced a spectrum of unusual, subtle, and often life-threatening lesions that can affect almost every organ and tissue in the body. With the introduction of laboratory serologic evidence of HIV infection, the spectrum of indicator diseases has extended beyond the classic opportunistic infections and Kaposi sarcoma. An analysis of 28 patients in Zimbabwe with focal areas of vascular disease treated during a 4-year period (1989-1993) defined 16 patients ranging in age from 12 to 46 years appropriate for special scrutiny as they evinced none of the usual causes of vascular disease. Twelve of the patients were HIV-positive; in two patients the serologic status was unknown; and two patients were HIV-negative at the time of their presentation. There were special clinical features in this group of patients selected for study: (1) They were young with a mean age of 31 years; (2) they were all indigenous Africans with no evidence of atherosclerosis; and there was (3) rapid development of focal necrotizing vasculitis with aneurysm formation and rupture or (4) slow, progressive development of granulomatous vasculitis. The sites of cardiovascular involvement included the left ventricle; aortic arch; thoracic, thoracoabdominal, and abdominal aorta; and iliac, femoral, gluteal, popliteal, and subclavian arteries. It is inferred that the association between HIV-positive status and arterial aneurysms or fibroproliferative aortic occlusion are causally related and that the principles of vascular surgery can be successfully applied to their treatment.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

Validity and reliability of cardiac output by CO2 rebreathing.

This article reviews the available literature on the validity and reliability of the non-invasive techniques, commonly known as CO2 rebreathing, for estimating cardiac output. The differing indirect methodologies are described and illustrated. A table, constructed from the available literature, comparing criterion versus estimated cardiac outputs is presented. The varying combinations of methods employed, differing measurement conditions, i.e. rest and exercise, and divergent populations are illustrated and discussed. The correlation between criterion and estimated cardiac output for these studies ranged from r = 0.09 to 0.96, with a % standard deviation of the differences of 1.5 to 176.8%. The Collier and end-tidal methods, in conjunction with either the Comroe or McHardy CO2 dissociation curve appears to be the most established, valid and reliable combination of methods for estimating resting cardiac output. These methods appear to be comparable to the combination of the Defares, end-tidal and Comroe curve methods for estimating cardiac output during exercise. Because of the potential for large errors, caution is urged when interpreting cardiac output results based on indirect estimation for individual assessment, or for subjects with certain types of pulmonary or heart diseases.

Carbon Dioxide↗
PubMedDate not supplied

Surgical treatment of left ventricular aneurysms.

An analysis of 37 patients surgically treated for left ventricular aneurysms provides preoperative clinical information regarding surgical risk. Operative mortality can be correlated with clinical and cardiac functional data as well as with the extent of coronary artery disease. Review of operative mortality in relation to the surgical procedure and the functional status of survivors indicates that aorto-coronary bypass grafting, complementary to aneurysmectomy, not only relieves angina pectoris, but also improves the functional status of the residual myocardium.

Adult↗
PubMedDate not supplied

The embryologic basis of tracheobroncho-pulmonary maldevelopment.

An integrated analysis of 15 patients with tracheobronchial abnormalities, bronchogenic cysts and pulmonary sequestration demonstrates that these diverse clinical conditions are expressions of basic embryologic maldevelopment patterns. The clinical conditions described are indicative of differences in degree of the embryologic disorder. In addition to the clinico-pathologic changes affecting the tracheobroncho-pulmonary components of the respiratory system, the importance of aberrant pulmonary arterial blood vessels is described and the diagnostic importance of ancillary investigations is emphasized.

Bronchi↗