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Biomedical subjects

C Marais

Publications and source records attributed to C Marais.

7 recordsLinked to original sources
PubMed1985

[The role of Agreal in the treatment of the menopause].

The treatment of menopause comprises two phases: on the one hand, the curative treatment of the premature climateric syndrome, including a case by case discussion of the value of a hormonal or non-hormonal treatment; on the other hand, the preventive treatment of delayed deficiency, for which only opotherapy, using estrogens and progestatives, is indicated. The therapeutic choice is guided, in the first case, by the existence or non-existence of an objective counter-indication to the use of estrogens or of reticence on the part of the patient to the use of a hormonal treatment. In the second case, the decision is based only on the benefit/risk ratio, and estrogeno-therapy, in the opinion of many, should be reserved for women in whom estrogen deficiency has been demonstrated. Veralipride (Agreal) is, medically speaking, a non-hormonal drug, and has a proven efficacy in vasomotor heat flushes and the psychofunctional signs of confirmed menopause. It is well tolerated and is easy to use.

Adult↗
PubMed1984

[Antibacterial and genotoxic properties of 33 mycotoxins].

Most of the 33 fungal metabolites tested provoke: Bacterial growth inhibition of Bacillus thuringiensis similar to lethal effect of antibiotics. Positive response in the 'Rec' assay using strains of Bacillus subtilis; this fact shows that these toxins are DNA modifying agents. Enlargement of cell volume in the first bacteria species; this cell-abnormality induction resembles those obtained with mitomycin C. Correlation between elongation of cells (filamentation) and in vivo carcinogenicity of mycotoxins is discussed. The filamentation should be an expression of a perturbated DNA replication (S.O.S.-error prone repair) as the consequence of DNA damages induced by genotoxic agents (i.e. carcinogens).

Bacillus subtilis↗
PubMed1978

[Duality of dopaminergic receptors. Pharmacologic and clinical perspectives].

A univocal disorder of dopaminergic activity in the nerve structures responsible for extra-pyramidal motility does not take into account the total phenomena seen in psychomotor neurological studies. The hypothesis of two categories of dopaminergic receptors-respectively excitatory (DA) and inhibitory (DAi)--in the striatal and mesolimbic structures concerned, was derived from experimental and clinical anatomical cytological, and pharmacological data. This duality of the receptors could establish a relationship between dopaminergic mediating, mechanism and adrenergic mediation for with the existence of a least two types of distinct receptors, alpha and beta, has been demonstrated. The author discusses the physiopathology of neuromotor disorders wuch as Parkinson's disease, chorea, and various types of dyskinesias, in relation to this dual mediation. By separation of dopamine antagonists and agonists in this new context, it should be possible to have a more selective approach, which would be better adapted, therefore, for the treatment of these affections. The study of the effects of a new medication, tiapride, on dyskinesias provoked by levodopa in parkinsonian patients, is a step forwards in this new method exploration in neurology.

Animals↗
PubMedDate not supplied

A comparative study on the suppression of peritoneal adhesion formation in the rat.

The importance of periadnexal adhesions as cause in female infertility is widely recognized. The incidence of salpingo-ovariolysis (in the absence of tubal obstruction) has been reported as being 35% of the surgical procedures to promote fertility. In addition, one of the important causes of failure of reconstructive fertility surgery is related to postoperative adhesions (either reformed of formed de novo). Adhesions may encapsulate the ovary and/or the terminal end of the oviduct; they may disturb the physiologic spatial, relationship between the fimbriae and ovary and thus impair ovum pick up. Adhesions may also disturb ovarian function decreasing the number of ovulations. The importance of postoperative adhesions is evident also by the vast numbers of studies, published on this subject in the last decade.

Animals↗