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Biomedical subjects

C Manso

Publications and source records attributed to C Manso.

At least 37 records · Page 2Linked to original sources
PubMed1989

Decreased plasma benzylamine oxidase in a subgroup of schizophrenia.

Plasma benzylamine oxidase (BzAO) activity was analysed in a group of 40 schizophrenic patients and compared with that of healthy controls. Although plasma BzAO was significantly decreased in schizophrenics as a whole, when patients were divided into type I (favourable course) and type II (poor course) it was found that the reduced BzAO activity was only observed in type I. Several clinical features were associated with a low BzAO level. The clinical and biological significance of the identification of a biochemical alteration in a subgroup of schizophrenic patients is discussed, and we suggest that the possibility of BzAO being a marker for prognosis in schizophrenia should be further investigated.

Adolescent↗
PubMed1989

[Oxygen radicals and hypertension].

The Author reviews the problem, starting with a short introduction about oxygen free radicals. He discusses the vascular factor, emphasizing the importance of several known relaxants, EDRF, prostacyclin, monooxigenated arachidonate derivatives, ANF, hydrogen peroxide and hydroxyl radical. He analyses the involvement of free radicals in kidney damage and presents evidence for their formation during cerebral vascular accidents.

Arachidonic Acid↗
PubMed1988

Mechanisms of hemolysis induced by copper.

An excess of copper is the cause of hemolysis in a number of clinical conditions. Incubation of human erythrocyte (RBC) suspensions with copper (II) causes the formation of methemoglobin, lipid peroxidation and hemolysis. A new variant of the thiobarbituric acid (TBA) method, which minimizes the formation of interfering chromophores, was used to detect lipid peroxidation. Lipid peroxidation precedes hemolysis and the antioxidant vitamins C and E, which inhibit lipid peroxidation, also inhibit hemolysis. Consequently lipid peroxidation appears to be the cause of RBC destruction. Lipid peroxidation arises mostly from the oxidation of oxyhemoglobin by copper as it is inhibited in RBCs with carbon monoxyhemoglobin or methemoglobin. A direct interaction of copper with the red cell membrane seems to play only a minor role. Copper effects depend on the presence of free SH groups. Lipid peroxidation is probably initiated by activated forms of oxygen as it is increased by an inhibitor of catalase and reduced by hydroxyl radical scavengers. With higher copper concentrations hemolysis is greater: its mechanism appears different as lipid peroxidation is smaller but hemoglobin alterations, namely precipitation, are more pronounced.

Ascorbic Acid↗
PubMed1988

Superoxide radical generation by Amadori compounds.

Several D-sugars were incubated with L-lysine or with L-arginine for 10 days. The resulting compounds are able to reduce nitrobluetetrazolium (NBT). This is prevented by superoxide dismutase (SOD), indicating that the superoxide radical is generated by the resulting Amadori compounds. The formation of superoxide radical in vivo, as a result of nonenzymatic glycosylation of proteins, may be considered to be a contributory factor to the appearance of chronic complications of diabetes.

Carbohydrate Metabolism↗
PubMed1987

Mannose inhibition as a significant marker for differentiating among novobiocin-resistant staphylococci of relevance in clinical microbiology.

A specific method for the identification of Staphylococcus saprophyticus among novobiocin-resistant species isolated from man is described. The test is based on novobiocin resistance, non-fermentation of D-mannose and early inhibition with late secondary growth on glucose/mannose + novobiocin agar plates. On this medium novobiocin-resistant Staphylococcus cohnii showed a confluent, continuous and homogeneous growth after 24 h which remained unchanged at 48 h whether or not it fermented D-mannose, whereas novobiocin-resistant Staphylococcus xylosus fermented D-mannose. These results are discussed in relation to a possible causal role of PTS enzymes and phosphomannose isomerase deficiency in mannose inhibition.

Drug Resistance, Microbial↗
PubMed1987

The neutralization of hydroxyl radical by silibin, sorbinil and bendazac.

The compounds silibin, sorbinil and bendazac act as hydroxyl radical scavengers, when the hydroxyl radical is generated by the Fenton reaction. Hydroxyl was detected by the degradation of deoxyribose. The Authors discuss the possibility that the scavenger activities of those compounds may explain, at least in part, their therapeutic activity.

Antioxidants↗
PubMed1986

Putative reverse transcriptase intermediates of human hepatitis B virus in primary liver carcinomas.

Nucleocapsid-pol fusion proteins have been detected by serological screening hepatocellular carcinoma tissues that contain hepatitis B virus (HBV) DNA. The existence of these fusion proteins suggests that HBV may synthesize its reverse transcriptase in a fashion analogous to the way that retroviruses synthesize and process a precursor. The accumulation of HBV reverse transcriptase intermediates in tumorous tissues and not in other tissues may be related to the absence of viral core particles and possibly contributes to tumor development.

Animals↗
PubMed1985

Inhibitory effect of drugs used in the treatment of Parkinson's disease on plasma monoamine oxidase activity.

The plasma amine oxidase (benzylamine oxidase, BzAO) of patients with Parkinson's disease is sometimes decreased in activity, when compared to normal controls. This is the result of therapy with DOPA decarboxylase inhibitors. The Authors suggest that complications due to prolonged therapy with these drugs may be, at least in part, the result of an interference with BzAO capacity to catabolize circulating amines.

Adult↗
PubMed1984

Cloned duck hepatitis B virus DNA is infectious in Pekin ducks.

Approximately 10% of German-bred Pekin ducks were found to be chronically infected with duck hepatitis B virus (DHBV). The genomes of three German DHBV isolates analyzed were closely related but showed substantial restriction site polymorphism compared with U.S. isolates. We tested the infectivity of three sequence variants of cloned DHBV DNA by injecting them into the liver of virus-free ducklings. Most of these animals injected with double-stranded closed-circular or plasmid-integrated dimer DHBV DNA developed viremia, demonstrating the infectivity of all three cloned DHBV DNA variants. The cloned viruses produced were indistinguishable from those from naturally infected animals, implying that our experimental approach can be used to perform a functional analysis of the DHBV genome.

Animals↗
PubMed1980

Erythrocyte acetylcholinesterase in essential hypertension.

Red cell acetylcholinesterase activity (AChE) has been studied in 58 patients suffering from essential hypertension; diastolic blood pressure values were about 130 mm or higher in 45 patients (group A) and lower in 13 (group B). The very significant increase (p < 0.001) of AChE activity in group A has been forced by the severity of systemic lesions. Meanwhile, the AChE values have been slightly increased, but not statistically significant in the patients of group B. These results are supporting the hypothesis that the blood pressure control can be mediated or normalized, at least in part, by cholinergic mechanisms.

Acetylcholinesterase↗
PubMed1975

Immunoglobulin allotypes in portugal.

The frequency of several immunoglobulin allotypes has been evaluated in a sample of 419 Portuguese subjects. It was found that the percentage of Gm (1) and of Gm (2) are among the highest in Europe, although Portugal is situated in the extreme southwest of Europe. A few cases of dissociation of Gm (1) and Gm (2) were noted and attributed to the probable presence of African admixture.

Alleles↗