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Biomedical subjects

C Maher

Publications and source records attributed to C Maher.

46 records · Page 3Linked to original sources
PubMed1984

Pre-cystectomy intra-arterial cis-diamminedichloroplatinum II with local bladder hyperthermia for bladder cancer.

A total of 6 patients with bulky pelvic bladder cancer underwent combination cis-diamminedichloroplatinum II (cisplatin) hypogastric artery infusion and local bladder hyperthermia as a preoperative adjunct to radical cystectomy. Pathological examination showed extensive tumor necrosis on the luminal side, with a gradient of tumor destruction to viable tumor on the serosal surface in 4 of the 6 bladders, while 2 specimens showed no tumor. Uninvolved portions of the bladders showed minor changes in the urothelium, submucosal edema and no effect on detrusor muscle or perivesical fat. Analysis of tissue for platinum revealed uptake by the tumors and normal tissues. Systemic effects of spillover cisplatin were not seen. Adjunctive preoperative hypogastric artery infusion of cisplatin is safe and well tolerated. Further study is required to determine the upper limits of safety of the regimen.

Carcinoma, Transitional Cell↗
PubMed1983

Effects of dietary fat and gel-forming substances on rat jejunal disaccharidase levels.

Wistar rat jejunal disaccharidases were measured after feeding low fat, low fat + 5% pectin, low fat + 0.4% galactomannan, high fat, high fat + 5% pectin and high fat + 0.4% galactomannan diets for 16 weeks. All rats fed high fat diet had significantly lower jejunal sucrase and maltase levels when compared with their respective low fat groups. Lactase was significantly lowered in the high fat pectin group compared with the low fat pectin group, but was not significantly different when comparing the high fat or high fat galactomannan with their respective low fat groups. There was no significant difference in lactase, sucrase or maltase levels between the low fat groups, or between the high fat groups. We conclude that in Wistar rats an increased dietary fat level lowers jejunal sucrase, maltase and lactase levels, while the gel-forming substances pectin and galactomannan added at the levels of 5% and 0.4%, respectively, have no effect.

Animals↗
PubMed1979

Deficits in psychologic and classroom performance of children with elevated dentine lead levels.

To measure the neuropsychologic effects of unidentified childhood exposure to lead, the performance of 58 children with high and 100 with low dentine lead levels was compared. Children with lead levels scored significantly less well on the Wechsler Intelligence Scale for Children (Revised) than those with low lead levels. This difference was also apparent on verbal subtests, on three other measures of auditory or speech processing and on a measure of attention. Analysis of variance showed that none of these differences could be explained by any of the 39 other variables studied. Also evaluated by a teachers' questionnaire was the classroom behavior of all children (2146 in number) whose teeth were analyzed. The frequency of non-adaptive classroom behavior increased in a dose-related fashion to dentine lead level. Lead exposure, at doses below those producing symptoms severe enough to be diagnosed clinically, appears to be associated with neuropsychologic deficits that may interfere with classroom performance.

Attention↗
PubMedDate not supplied

Normal response to large posteroanterior lumbar loads--a case study approach.

OBJECTIVE: Characterization of the responses to spinal posteroanterior loading has involved measuring the gradient of the linear region of the force-displacement relationship between 30 N and 100 N of applied force. However, forces applied during manual assessment of stiffness may reach 300 N. This study investigated whether the force-displacement relation remains linear above 100 N. DESIGN: A single-case-study design with replication was used. SUBJECTS: Two male subjects, with no history of low back pain requiring treatment over the preceding twelve months, participated in this study. METHODS: Posteroanterior loads of 275 N were applied to the 1.3 vertebra of both subjects using a mechanical device. The force-displacement responses in these subjects were measured and analyzed to examine the linearity of the data. RESULTS: The responses from the two subjects were similar. In both cases, the responses were approximately linear at all levels of load up to 275 N. Because of the small degree of nonlinearity, there was a tendency for the stiffness to show moderate increases as the load increased. Stiffness was approximately 25% greater when calculated between 30 N and 275 N than when calculated between 30 N and 100 N. CONCLUSION: In these two subjects, the force-displacement relation was approximately linear for all three force intervals considered, although there was some increasing stiffness with increasing force.

Adult↗