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Biomedical subjects

C Mage

Publications and source records attributed to C Mage.

9 recordsLinked to original sources
PubMed1999

Economic benefits of prophylaxis with diclazuril against subclinical coccidiosis in lambs reared indoors.

One hundred and twenty weaned male lambs, naturally infected with Eimeria species, were used to assess the economic benefits of the prophylactic administration of diclazuril. They were randomly divided into four groups of 30 lambs on the basis of their bodyweight and output of oocysts. The groups were either left untreated (group 1), treated orally with a simple dose of diclazuril at 1 mg/kg (group 2), with two doses two weeks apart (group 3), or with sulphadimethoxine at 50 mg/kg for five consecutive days (group 4). No clinical signs of coccidiosis were observed in any of the groups. The output of oocysts was significantly reduced on day 7 after treatment in group 2, on days 7, 14 and 28 in group 3 and on days 7 and 14 in group 4. No significant differences were found between the treated and untreated groups for bodyweight, carcase weight and carcase classification. The mean fattening period was shorter for the treated lambs (52 and 55 days) than for the untreated controls (60 days). The average growth rate of the lambs treated twice with diclazuril and with sulphadimethoxine was improved and the feed conversion rates of the lambs treated once or twice with diclazuril were 7 per cent and 16 per cent better than that of the untreated lambs.

Animal Husbandry↗
PubMed1999

Pharmacokinetics of eprinomectin in plasma and milk following topical administration to lactating dairy cattle.

The pharmacokinetics and mammary excretion of eprinomectin were determined in cattle following topical administration at a dose rate of 0.5 mg kg(-1). The kinetics of plasma and milk concentrations were analysed using a one-compartment model. The maximum plasma concentration of 43.76 ng ml(-1)occurred 2.02 days post administration, and the mean residence time was 4.16 days. Eprinomection was detected in the milk at the first sampling time and thereafter for at least 15 days. Comparison of the milk and plasma data demonstrated the parallel disposition of the drug in the milk and plasma with a milk / plasma concentration ratio of 0. 102+/-0.048. The amount of drug recovered in the milk during this period was 0.109% +/- 0.038 of the total administered dose. This very low extent of mammary excretion resulted in low concentrations of eprinomectin in milk. This supports the permitted use in lactating cattle, as the maximum level of residue in milk did not exceed the maximum acceptable limit of 30 ng ml(-1).

Administration, Topical↗
PubMed1992

Immunological detection of chemotherapeutic success in bovine fasciolosis using the specific antigen f2.

An improved hemagglutination (HA) test using the purified specific f2 antigen of Fasciola hepatica has been evaluated with regard to its potential use for the prediction of chemotherapeutic success in natural bovine infections with F. hepatica. Lactating cows (n = 16) from a herd naturally infected with F. hepatica were successively treated with nitroxynil (Dovenix, Specia) and with oxyclozanide (Zanil, ICI) 1 month later. Their f2-specific antibodies were significantly lower than those of a non-treated control group (n = 15) from the second month after the first treatment, and continued to decline thereafter to negative values 5-6 months post-treatment. In a second experiment, culled and fattened cows (n = 32) of unknown fasciolosis history were treated with closantel (Janssen Pharmaceutica). Three months after treatment, f2-specific antibodies of the serologically positive animals (n = 24) were reduced nine-fold. In contrast, in the control group (n = 28), the titers of f2-specific antibodies of the serologically positive animals (n = 21) were not modified significantly. The results show that the f2-HA test is useful for the prediction of chemotherapeutic success in bovine fascioliasis.

Animals↗
PubMed1992

Early immunodiagnosis of bovine fascioliasis using the specific antigen f2 in a passive hemagglutination test.

An improved hemagglutination (HA) test using the purified specific f2 antigen of Fasciola hepatica has been evaluated with regard to its potential use for early diagnosis of infection. On experimental infection of beef calves 6-8 months of age, f2-specific antibodies were detected 2-4 weeks after inoculation and persisted at high levels during the 28 week experimental period. On natural infection of dairy calves, 6-9 months of age, allowed to graze in infected fields from April to June, 48% of the animals were positive in July although coproscopic analyses were negative. In November all the calves were HA positive but only 24% of them excreted F. hepatica eggs. Beef calves 1-3 months of age allowed to graze with their dams in infected fields continued to suckle their dams and were weakly infected according to HA results. This weak infection was not detected by coproscopical analysis. Colostral f2-specific antibodies persisted for approximately 6 months in the serum of dairy calves allowed to suckle their dams immediately after birth.

Animals↗
PubMed1981

Major internal parasites interfering with cattle production in France, and experiments to control them by strategic treatments. A bibliographic review.

A summary of the cattle management systems and statistics in France is presented as a framework to examine the recently published results on the major internal parasites of cattle in France from numeric data on naturally infested animals. From these results the major or constant parasites are Fasciola, Dictyocaulus, Ostertagia and Cooperia; occasional but important parasites are Nematodirus, Neoascaris, Eimeria, OEsophagostomum and Cysticercus bovis. Pathology results focus on disease given by the most common nematode : Ostertagiasis. For prevention and control of infestations in farm practice with typical management procedures, results are presented in dairy cattle (Brittany and Normandy), and in beef cattle (Limousin).

Animals↗
PubMed1975

[Abnormalities of the aortic arches discovered at bronchography in children with bronchial disorders (author's transl)].

In four children, aged respectively 2, 6, 8 and 11 years, an abnormality of the aortic arches was discovered fortuitously during bronchoscopy. The latter was carried out in an attempt to assess bronchial lesions in children suffering from chronic or recurrent bronchopneumonia. The authors stress the importance of careful examination of the mediastinum in such cases, the diagnosis of the causal vascular abnormality (double aortic arch in all four cases) being possible by simple radiological examinations with no element of aggression.

Age Factors↗