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Biomedical subjects

C Madler

Publications and source records attributed to C Madler.

At least 19 recordsLinked to original sources
PubMed1998

Conscious awareness during general anaesthesia: patients' perceptions, emotions, cognition and reactions.

We interviewed 45 patients, who answered advertisements (n = 21) or were referred by colleagues (n = 24), about their experience of intraoperative awareness using a standardized questionnaire. Auditory perceptions, hearing sounds or voices were mentioned by all patients (45 of 45): 33 of 45 patients understood and recalled conversations; 21 of 45 patients had visual perceptions; 12 of 21 recognized things or faces; 29 of 45 patients felt being touched; three patients had the sensation of moderate pain; and eight patients were in severe pain. Patients' feelings were mostly related to paralysis (27 of 45), helplessness (28 of 45), anxiety and fear (22 of 45); 18 were in severe panic. All patients (45 of 45) recognized the situation as a real event: 22 of 45 patients experienced unpleasant after effects; 11 suffered from anxiety and nightmares; and three developed post-traumatic stress disorder syndrome and required medical treatment. Twenty of 45 patients were especially attentive to emotionally relevant remarks on their own person, their disease and the course of their operation. The accuracy of sensory perception indicates a very high level of cognitive performance of patients during intraoperative awareness.

Adult↗
PubMed1997

[Indicators of preoperative anxiety and anxiolysis from the anesthesiological viewpoint].

In recent times preoperative anxiety is again discussed as an important influential factor for perioperative complications. The anaesthesiologist may be important to identify and control the patients' anxiety although his time while on premedication visit is rather limited. The present article deals with the different aspects of preoperative anxiety, argues about possible psychological and physiological characteristics of anxiety and describes conventionally used psychophysiological testing for the identification of anxiety. Referring to the literature, different therapeutical options are given. Psychological techniques for reducing and controlling preoperative anxiety might be an important topic for further research, especially as far as their influence on perioperative morbidity and mortality is concerned.

Anxiety↗
PubMed1996

[Premedication].

Explore the source record for details and available documents.

Adult↗
PubMed1995

[Awareness during general anesthesia. Definition, incidence, clinical relevance, causes, avoidance and medicolegal aspects].

The possibility that a patient during general anaesthesia is aware of the operation going on and aware of severe pain that might be remembered postoperatively must be very alarming to patients and anaesthetists alike. Furthermore, there is experimental evidence showing that conscious recall of intraoperative events is only the tip of an iceberg; it seems very probable that there is even a higher incidence of unconscious perception during general anaesthesia. Therefore, the following stages of intraoperative awareness must be distinguished: (1) conscious awareness with explicit recall and with severe pain; (2) conscious awareness with explicit recall but no complaints of pains; (3) conscious awareness without explicit recall and possible implicit recall; (4) subconscious awareness without explicit recall and possible implicit recall; (5) no awareness. The incidence of conscious awareness with explicit recall and severe pain has been estimated at less frequent than 1/3000 general anaesthetics. Conscious awareness with explicit recall but no complaints of pain has been reported in the literature with an incidence of 05-2%. With 7-72%, conscious awareness without explicit recall and possible implicit recall shows a very wide range of variation and its occurrence probably depends on the anaesthetic drugs used. Subconscious awareness with possible implicit recall has an incidence of up to 80%, but there are many methodological problems in demonstrating implicit memory of intraoperative events. Reports of intraoperative awareness do not come exclusively from cardiac surgery and obstetrics, but also from all other operative specialties. Postoperatively, patients who experience intraoperative awareness may develop a so-called post-traumatic stress syndrome. Symptoms involve re-experiencing the event awake or in dreams, sleep disturbances, depression, avoidance of stimuli associated with the event. The probability of the development of the post-traumatic stress syndrome seems to coincide with the experience of severe pain. When a patient complains of intraoperative awareness postoperatively the anaesthesiologist should discuss the event frankly with the patient. When the symptoms of the post-traumatic stress syndrome persist a psychotherapy should follow. Causes for intraoperative awareness may be: equipment failure, too-light anaesthesia, e.g. for a caesarean section or for emergency surgery in severely injured or polytraumatized patients, during cardiac surgery, bronchoscopy of difficult intubation. There is interindividual variability in anaesthetic effect; for example, chronic drug or alcohol abuse or overweight may make increased anaesthetic doses necessary. They are at risk for intraoperative awareness. Some general anaesthetics or anaesthetic procedures, e.g. the combination of a relaxant and N2O, opioid mono-anaesthetics, or opioids combined with benzodiazepines, seem to involve a higher risk of intraoperative awareness than do volatile anaesthetics. The bases of litigation are medical malpractice, breach of contract by the anaesthesiologist or lack of informed consent from the patient. Therefore, patients who are at risk of intraoperative awareness should be given detailed information on this special risk before the operation.

Anesthesia, General↗
PubMed1995

Mid-latency auditory evoked potentials and wakefulness during caesarean section.

We investigated intra-operative wakefulness and mid-latency auditory evoked potentials (MLAEP) in 20 patients undergoing elective Caesarean section under general anaesthesia. Anaesthesia was induced with thiopentone 5 mg kg-1 i.v. and succinylcholine 1-1.5 mg kg-1 i.v. After delivery, a balanced anaesthetic technique was maintained using fentanyl 0.2-0.3 mg i.v., enflurane 0.4-1.0 vol% end-expired concentration and 50% N2O in oxygen. Purposeful movements were interpreted as signs of inadequate anaesthesia and intra-operative wakefulness. They were recorded as either spontaneous movements or in response to one of two audio tapes (tape A: sound of a crying baby; tape B: classical music). Post-operatively, intra-operative dreams, hallucinations and detailed reports about intra-operative events were evaluated. Auditory evoked potentials were recorded online before and during general anaesthesia. Twenty spontaneous purposeful movements were observed in 12 patients, seven before or during delivery and 13 after delivery. Four purposeful movements were observed after presentation of the sound of a crying baby but only one after classical music. Dreams and hallucinations were reported by nine patients. Two patients reported experiencing surgical manipulations. In the awake state MLAEPs had great peak-to-peak amplitudes and a periodic waveform. Under adequate levels of general anaesthesia MLAEPs showed a marked increase in latency and decrease in amplitude or were even suppressed completely. This increase in latencies and decrease in amplitude of MLAEP was absent in patients who reported intraoperative events and during spontaneous or provoked motor reactions.

Anesthesia, General↗
PubMed1994

Mid-latency auditory evoked potentials and circulatory response to loud sounds.

We investigated in 60 patients scheduled for elective aorto-coronary bypass grafting if loud sounds by themselves can induce cardiovascular responses and if these could be related to mid-latency auditory evoked potentials (MLAEP). Anaesthesia was induced in group I (n = 20) with flunitrazepam-fentanyl 0.01 mg kg-1 and maintained with flunitrazepam-fentanyl 1.2 mg h-1. Patients in groups II (n = 20) and III (n = 20) received etomidate 0.25 mg kg-1 and fentanyl 0.005 mg kg-1 for induction and 0.6-1.2 vol% isoflurane and fentanyl 1.2 mg h-1, or propofol 4-8 mg kg-1 h-1 and fentanyl 1.2 mg h-1 for maintenance of general anaesthesia. After preparation of the sternum the operation was stopped for several minutes. Then, as a loud auditory stimulus, the sound of the running sternotomy saw was presented to the patients by putting the saw inverted on the sternum for several seconds. Heart rate (HR), arterial pressure (SAP), pulmonary capillary wedge pressure (PCWP), cardiac index, systemic vascular resistance and MLAEP were measured in the awake state, before and after presentation of the sound. Latencies of the peak V, Na, Pa, Nb and P1 were measured. In group I there were statistically significant increases in HR (63.5-70.2 beat min-1), SAP (123.9-146-5 mm Hg) and PCWP (9.2-11.7 mm Hg) after presentation of the sound. These haemodynamic changes were not observed in patients in groups II and III. In the awake state, AEP had high peak -to-peak amplitudes and a periodic waveform.(ABSTRACT TRUNCATED AT 250 WORDS)

Anesthesia, Inhalation↗
PubMed1994

Midlatency auditory evoked potentials and purposeful movements after thiopentone bolus injection.

The effect of thiopentone on the middle latency auditory evoked potentials was investigated in 12 patients during induction of anaesthesia with thiopentone 5 mg.kg-1. 100% oxygen was administered throughout the induction, and when the patient moved purposefully a further bolus (2 mg.kg-1) was given, and anaesthesia continued in the normal way. The middle latency auditory evoked potentials were elicited before and during the induction. Binaural clicks (70 dB above normal hearing threshold) were presented at a rate of 9.3 per s. Averages of 1000 responses were analysed off line, and a fast Fourier transformation of the middle latency auditory evoked potentials were used to calculate the power spectrum of the averages. Awake, the patients had large peak to peak amplitudes and a normal waveform. The power spectra showed a high energy between 30-40 Hz. After induction the latencies of waves Na, Pa, Nb and P1 and the amplitudes of the waves Na/Pa, Pa/Nb, and Nb/P1 were decreased or completely attenuated. Both effects lasted for 4 min. When movement occurred (after 4-6 min), the values returned to awake. The second bolus repeated the changes.

Adult↗
PubMed1993

Effects of benzodiazepines on mid-latency auditory evoked potentials.

Midlatency auditory evoked potentials (MLAEP) reflect primary cortical processing of auditory stimuli. The effects of benzodiazepines on MLAEP have not yet been studied. We examined the effects of intravenous induction of general anaesthesia using the benzodiazepines midazolam, diazepam and flunitrazepam on MLAEP in 30 patients scheduled for minor gynaecological procedures. Anaesthesia was induced with midazolam (0.2-0.3 mg.kg-1, Group I, n = 10), diazepam (0.3-0.4 mg.kg-1, Group II, n = 10) or flunitrazepam (0.03-0.04 mg.kg-1, Group III, n = 10). Auditory-evoked potentials were recorded before and five to ten minutes after induction of general anaesthesia. Latencies of the peak V, Na, Pa, Nb and Pl (ms) and amplitudes Na/Pa, Pa/Nb and Nb/P1 (microV) were measured. In the awake state, MLAEP had high peak to peak amplitudes and a periodic waveform. After induction of anaesthesia there was no or only a small increase in latencies of the peaks Na, Pa, Nb and P1, which was significant only for P1 in the midazolam group. Amplitudes Na/Pa, Pa/Nb and Nb/P1 decreased only slightly and which reached statistical significance only for Na/Pa in the flunitrazepam group. The MLAEPs do not change markedly in amplitude or latency during induction of general anaesthesia with benzodiazepines. Primary cortical processing of auditory stimuli seems to be preserved under benzodiazepines. This may be seen in connection with cases of intraoperative awareness and especially the perception of auditory stimuli during anaesthetic regimens where benzodiazepines are used to suppress consciousness.

Acoustic Stimulation↗
PubMed1993

Mid-latency auditory evoked potentials during ketamine anaesthesia in humans.

We studied mid-latency auditory evoked potentials (MLAEP) during induction of general anaesthesia with ketamine 2 mg kg-1. MLAEP were recorded before, during and after induction of general anaesthesia on the vertex (positive) and mastoid (negative) positions. Latencies of the peak V, Na, Pa, Nb, P1 and amplitudes Na/Pa, Pa/Nb and Nb/P1 were measured. Fast-Fourier transformation was used to calculate power spectra of the MLAEP. In the awake state, MLAEP had large peak-to-peak amplitudes and a periodic waveform. Peak latencies remained within the normal range. Power spectra indicated high energy in the 30-40 Hz frequency range. After induction of general anaesthesia with ketamine, there was no change in latency of peaks V, Na, Pa, Nb, P1 and no apparent reduction in amplitudes Na/Pa, Pa/Nb and Nb/P1. In the power spectra, frequencies in the range of 30-40 Hz retained high energy. Amplitudes and latencies of MLAEP did not change during induction of general anaesthesia with ketamine. Primary processing of auditory stimuli in the primary auditory cortex seemed to be preserved under ketamine. Suppression of sensory (auditory) information processing must take place at a higher cortical level in a dissociative manner.

Adult↗
PubMed1993

[Monitoring intraoperative processing of acoustic stimuli with auditory evoked potentials].

130 Patients undergoing elective intra-abdominal, gynaecological, urological or cardiac surgery were studied after institutional approval and informed consent. In all patients auditory-evoked potentials (AEP) were recorded in the awake state and during general anaesthesia. Latencies of the peaks V, Na, Pa, Nb and P1 were measured. V belongs to the brainstem-generated potentials, which demonstrates that auditory stimuli were correctly transduced. Na, Pa, Nb, P1 are generated in the primary auditory cortex of the temporal lobe. During anaesthesia with isoflurane, enflurane, thiopentone, etomidate and propofol the peak V remains unchanged, whereas the mid-latency auditory-evoked potentials (MLAEP) show marked increases in latencies and decreases in amplitudes or are even completely suppressed. This indicates a successful stimulus transmission up to the level of the brainstem and midbrain. However, stimulus processing in the primary auditory cortex is blocked. Under increasing end-expiratory concentrations of isoflurane MLAEP show a dose-dependent increase of latencies and decrease of amplitudes. Under surgical anaesthesia with 1.2 vol%, MLAEP are nearly completely suppressed. A different picture can be seen when MLAEP were recorded during anaesthesia with the receptor-specific anaesthetics midazolam, flunitrazepam, diazepam, fentanyl and ketamine. During anaesthesia with receptor-specific anaesthetics, the brainstem peak V as well as the mid-latency components remain nearly unchanged compared with AEP from awake patients. This indicates that auditory stimuli reach the primary auditory cortex and are processed at a primary cortical level. With increasing doses of fentanyl one can observe only a significant decrease of amplitudes for the late component P1.(ABSTRACT TRUNCATED AT 250 WORDS)

Acoustic Stimulation↗
PubMed1992

Propofol/fentanyl versus etomidate/fentanyl for the induction of anesthesia in patients with aortic insufficiency and coronary artery disease.

The purpose of this study was to gain information about the hemodynamic effects following the induction of anesthesia with fentanyl and either 1 mg/kg of propofol (P) or 0.25 mg/kg of etomidate (E) in ASA III-IV patients with aortic insufficiency (AI) or coronary artery disease (CAD). Four patient groups resulted: (1) AI and P, n = 10; (2) AI and E, n = 10; (3) CAD and P, n = 6; and (4) CAD and E, n = 8. Hemodynamics were recorded in the awake state, following induction, intubation, and 10 minutes after intubation. No complications occurred in groups 1, 2, and 4. In 2 patients of group 3, who suffered from three-vessel CAD, induction resulted in severe hypotension associated with an increase in pulmonary capillary wedge pressure. Because of this, the investigation of group 3 was prematurely terminated after the sixth patient. The following changes were observed under general anesthesia: in all four groups, arterial pressure (AP), cardiac index (CI), and left ventricular stroke work index decreased. Significantly different values between group 1 (AI and P) and 2 (AI and E) were observed for heart rate (HR) (P less than E), stroke volume (SV) (P greater than E), arterial elastance (Ea), and systemic vascular resistance (SVR) (P less than E); differences between group 3 (CAD and P) and 4 (CAD and E) were seen for AP, Ea, and SVR (P less than E each). After tracheal intubation, baseline values of AP and HR were not surpassed in any group. Signs of systolic myocardial dysfunction were present in all groups (P greater than E).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1991

[Sensory information processing during general anesthesia-- acoustic-evoked 30-40 Hz oscillations and intraoperative wakefulness during cesarean section].

Neuropsychological and neurophysiological investigations indicate that the underlying framework of adequate sensory information processing is a 30-40 Hz oscillatory brain mechanism, which also can be observed in mid-latency auditory evoked potentials (MLA-EP). Since high incidence of stimuli perception and wakefulness is a phenomenon during Caesarean section under general anaesthesia it was studied if auditory evoked 30-40 Hz oscillation correlate with intraoperative wakefulness during this surgical procedure. Following informed consent, 21 patients were selected for elective Caesarean section. Anaesthesia was induced with thiopentone (5 mg/kg b.w. i.v.) and maintained with thiopentone bolus injection (1-2 mg/kg b.w.i.v). and O2/N2O 1:1 according to clinical signs of adequate anaesthesia. After delivery, a balanced anaesthetic technique using fentanyl, enflurane and N2O in O2 1:1 was employed. Clinical signs of intraoperative wakefulness were spontaneous movements of the limbs, mimics, eye-opening, wakefulness after auditory stimulation (tape A: crying baby, tape B: classical music), one hour and 24 hours postoperatively reported dreams, hallucinations and detailed reports about intraoperative events. Auditory evoked potentials were recorded on-line before and during general anaesthesia, during the entire surgical procedure. Latencies of the peaks V, Na, Pa were measured. Employing Fast-Fourier transformation analysis, corresponding power spectra were calculated to analyse energy portions of AEP's frequency components. Spontaneous motoric movements occurred in 60% of the patients and did not correlate with heart rate, blood pressure or other clinical signs of inadequate anaesthesia. Provoked motoric reactions were 4 times as often after presentation of tape A as after tape B.(ABSTRACT TRUNCATED AT 250 WORDS)

Acoustic Stimulation↗
PubMed1991

[The effect of thiopental on mid-latency auditory evoked potentials and their frequency analysis].

The effect of Thiopentone on mid-latency auditory evoked potentials has not yet been examined sufficiently. Therefore, mid-latency auditory evoked potentials during induction of general anaesthesia with thiopentone were studied. Following informed consent in 10 patients scheduled for elective surgery, anaesthesia was induced with thiopentone (5 mg/kg b.w. i.v.). Assisted ventilation via face mask with 100% O2 was performed until the first purposeful movement of the limbs appeared. Then a second bolus of thiopentone (2 mg/kg b.w. i.v.) was given and general anaesthesia was maintained according to anaesthesiological and operative necessities. Auditory evoked potentials were recorded in the awake and on-line when thiopentone was injected up to 9 min after the onset of general anaesthesia. Latencies of the peaks V, Na, Pa were measured. Using Fast-Fourier-Transform-Analysis, corresponding power spectra were calculated to analyse energy portions of the AEP frequency components. In the awake state peak latencies were in the normal range. Corresponding power spectra indicated energy maxima in the 30-40 Hz frequency range. After induction of general anaesthesia an increase in latencies of the peaks Na, Pa could be observed. The energy in the 30-40 Hz range became suppressed, the AEP energy maxima shifted to the low frequency range. These effects were observable until 3 min after injection. When the first purposeful movement of a limb occurred, Na, Pa latencies returned to normal values and most part of the AEP-energy was in the 30-40 Hz range as in the awake.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗