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Biomedical subjects

C Maayan

Publications and source records attributed to C Maayan.

65 records · Page 4Linked to original sources
PubMed1982

Does the pattern of ventilation determine the degree of lung damage following intensive care of the newborn?

Lung function tests were performed on 14 infants 22 to 67 wk following mechanical ventilation of 6 h to 51 days and on 5 infants of comparable age who had been treated with continuous positive airway pressure (CPAP). Airway resistance increased (P less than 0.01) and specific airway conductance decreased (P less than 0.001) in the ventilated infants compared with the CPAP-treated group who were normal. The airway resistance and specific airway conductance were normal in two ventilated infants and in one CPAP-treated infant who were studied earlier in the neonatal period. There were no significant differences in thoracic gas volume between groups of ventilated and nonventilated babies studied initially or at follow-up. There was no relationship between lung damage and the following: peak inspiratory pressure, the duration of high pressure ventilation, the level of CPAP or its duration, or the duration of greater than 60% oxygen administration. The degree of lung damage was not related to the maximum ventilatory frequency used, but there was a significant correlation with the duration of rapid frequency ventilation. This study supports the view that barotrauma is a major cause of lung disease following neonatal intensive care.

Airway Resistance↗
PubMed1980

Leiomyomatous hamartosis with congenital jejunoileal atresia.

An unusual case of congenital multiple atresias of the small intestine produced by leiomyomatous hamartosis is described. Leiomyomatous hamartomas were also found in the liver and lungs. It is suggested that these proliferative lesions represent a primitive form of inflammatory reaction to injury occurring during early fetal life.

Female↗
PubMed1979

Computer image analysis of kidney histopathological sections.

Human renal histological sections have been photographed on a black and white transparency and digitized. The digitizing camera, an image dissector, converts a 2 cm2 picture into 400 x 400 numbers each representing the grey level value of sampled point. The grey levels are represented in the computer by number ranging between 0-255. In this scale 'O' stands for black and 255, for white. The program provides 2 grey level thresholds, which outline a window through which the picture is scanned. Only structures, whose grey level value lies in the window range, are taken into consideration. The thresholds are set during digitization from the console switches. Image analysis is performed on-line in real time.

Color↗
PubMed1978

Heart failure apparently due to overfeeding in a neonate.

Severe heart failure in a one-month-old infant is described, apparently due to the administration of cows' milk in the region of 300 ml/kg per day. There was also pronounced hypocalcaemia. The infant responded rapidly to treatment with no evidence of intrinsic heart disease.

Animals↗
PubMedDate not supplied

Flow-pressure looping during plethysmography in wheezy infants.

Marked looping of the expiratory portion of the flow-pressure relationship was noted in some infants during measurements of airway resistance in a whole-body plethysmograph while the respired air was maintained at body temperature and humidity. An investigation of 13 infants who had varying degrees of airway obstruction showed that there was a negative correlation (r = 0.72) between the severity of the looping and specific airway conductance (SGaw). An even stronger correlation (r = 0.85) was found between the tangent of the angle of phase lag between flow and pressure (theta) and the forced expiratory time constant (t) obtained from the partial forced expiratory flow-volume curve. Such a relationship would be predicted from a model in which the lung behaved as a simple electrical resistance-capacitance network during expiration. It is suggested that the looping is the result of small airway closure during expiration in wheezy infants, with a consequent rise in resistance and prolongation of the time constant of the lung.

Airway Resistance↗
PubMedDate not supplied

The functional response of infants with persistent wheezing to nebulized beclomethasone dipropionate.

Lung function was measured in nine infants, ages 15-36 weeks, who had persistent wheezing, apparently following acute bronchiolitis, before and after 2 weeks of treatment with either inhaled nebulized beclomethasone dipropionate (BDP) or placebo in a randomized, double blind, crossover trial. The effect of nebulized albuterol (Salbutamol) was measured before and after the steroid treatment. Thoracic gas volume (TGV) and specific airway conductance (SGaw) were determined using a whole body plethysmograph, and forced expiratory flow at resting lung volume (VmaxFRC) was determined with a thoracoabdominal compression jacket. All infants had marked airways obstruction before treatment with mean +/- SE VmaxFRC of 24 +/- 4% predicted and SGaw of 37 +/- 5% predicted. Two weeks of placebo treatment had no significant effect on lung function, but after 2 weeks of BDP inhalation there was a significant rise in SGaw to 61 +/- 7% (P less than 0.005). VmaxFRC increased to 42 +/- 13% but the difference did not reach significance. Respiratory rate and clinical score for retractions and wheezing also fell significantly with BDP therapy (P less than 0.01 and P less than 0.001 respectively). Albuterol had no effect on lung function either before or during steroid therapy. Steroids may have a role in the management of persistent wheezing following bronchiolitis.

Administration, Intranasal↗
PubMedDate not supplied

Is there a place for rigid bronchoscopy in the management of pediatric lung disease?

A review of 364 rigid bronchoscopies in children is presented of whom 55% were younger than 3 years old. The commonest diagnoses in the under 1 year old group were related to congenital anomalies, in the 1-3 year group to inhaled foreign bodies, and in the over 3 year group to bronchiectasis. It is noted that some 30-40% of the tests could have been undertaken with a flexible bronchoscope, but it is suggested that the advantages of the flexible instrument in children with lung disease, as distinct from upper airway disease, are less than in adult practice. Clear benefits for the management of the patient should be obvious before undertaking bronchoscopy in children, and careful consideration should be given to the type of instrument most likely to provide the results desired.

Adolescent↗
PubMedDate not supplied

Calcitonin gene related peptide in familial dysautonomia.

Familial dysautonomia (FD) patients have diminished sensory C-fibers. Calcitonin gene related peptide (CGRP) is a widely distributed neuropeptide and prominent neurotransmitter in C-fibers. We show that plasma CGRP levels measured by radioimmunoassay is significantly lower in 51 FD patients compared to controls (P<0.001). In 11/51 FD patients with FD crisis and in 19/51 FD patients with pneumonia, the mean CGRP levels rose significantly as compared to their baseline (P<0.003, P<0.001, respectively). The deficiency of CGRP in FD patients is consistent with their depletion of C-fibers, and may explain some of their symptoms, either directly or via modulation of sympathetic activity.

Adolescent↗