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Biomedical subjects

C M Williamson

Publications and source records attributed to C M Williamson.

22 records · Page 2Linked to original sources
PubMed1988

Identification of an essential virulence region on Salmonella plasmids.

An 8 kilobase pair (kbp) fragment from the Salmonella dublin 2229 plasmid is sufficient to restore virulence for mice to cured strains of both S. dublin and S. typhimurium but only when cloned on a low copy vector. Two regions previously shown to be associated with virulence lie outside the fragment and complementation results suggest that one of these mutated regions affects expression from the 8 kbp fragment. It therefore appears that there are control elements both within and adjacent to the essential virulence fragment.

Animals↗
PubMed1988

A common virulence region on plasmids from eleven serotypes of Salmonella.

Cured derivatives of Salmonella dublin and S. typhimurium showed reduced virulence following oral infection of mice (10(4)-10(5)-fold for S. dublin, 10(2)-fold for S. typhimurium). Large plasmids from S. dublin and S. typhimurium independently restored virulence to the cured S. dublin but truncated S. dublin plasmids with deletions in a previously identified virulence region did not. This common virulence region identified in plasmids from S. dublin and S. typhimurium was shown to be carried on plasmids from 11 other serotypes of Salmonella but was absent from 10 plasmid-containing serotypes. TnA and Tn10 were transduced from the virulence region of two TnA-insertion mutants of S. dublin and one Tn10-insertion mutant of S. typhimurium that showed diminished virulence to recipient wild-type strains of S. dublin, S. enteritidis and S. typhimurium. Each transductant showed a decrease in mouse virulence within the range 10(3)-10(5). It is therefore proposed that similar virulence determinants are expressed in different serotypes. It was also shown that integration that occurred during curing was Tn10 dependent.

Plasmids↗
PubMed1983

Clinical evaluation of piroxicam in acute musculoskeletal injuries seen in general practice.

One hundred and sixty patients with acute musculoskeletal injuries were treated with piroxicam in conjunction with conventional methods of therapy. The median duration of therapy was 7 days, the majority of patients taking 20 mg piroxicam once daily. Assessments made before and at the end of treatment showed significant improvement in stiffness, swelling, heat, pain on movement, loss of movement and loss of function, and the overall effectiveness of treatment was rated by the physicians as excellent or moderate in 145 (94.8%) of the 153 patients with complete records. On patient self-assessment of daytime and night time pain, loss of function and need for supplementary analgesia (with paracetamol only), improvement was rated as marked or moderate by 119 (86.8%) of the 137 patients with adequately recorded assessments. Side-effects, mainly gastro-intestinal, occurred in 16 patients, but only in 1 patient did treatment have to be stopped.

Acute Disease↗